Professional Documents
Culture Documents
Permeation
Movement of drug molecules within the biologic
environment from one area to another
In the body we have several compartments that separate A neutral molecule that can reversibly dissociate into an
it with a lipid membrane anion (- charged molecule) and a proton (+ charged
Factors: molecule)
o Lipid layer Proton acceptor
Henderson-Hasselbach Equation
pH of the surrounding environment affects the movement
of the molecules
Describes the derivation of pH as a measure of acidity in
biological and chemical systems
A drug molecule can exist as a weak acid or a weak base
In an acidic environment
Weak acid = kuha ng proton, LIPID SOLUBLE,
movement is faster
Weak base = di maglabas ng positive charge, less
lipid soluble, unprotonated, not reabsorbed
(TRAPPING or repelled from reabsorption)
In alkaline environment
Weak acid = less lipid soluble, not absorbed,
slower movement
Weak base (meth) = releases positive,
unprotonated, more lipid soluble, faster
absorption
Special Carriers
For substances that are important for cell function
For too large and too insoluble lipid to diffuse passively
1. Special carriers are selective
2. Special carriers are saturable (limited)
3. Special carriers are inhibitable (can disrupt the function of
the special carrier)