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Formulasi sediaan
solida
{ fitofar

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Hardness : The hardness of tablets
is defined as the force required to
break the tablet in diametric
compression test. The hardness of
three tablets from each formulation
was determined by Monsanto
hardness tester. Hardness was
expressed in kg.
Disintegration : Six tablets were placed
in the tubes along with a plastic disk over
the tablets. The disk imparts pressure on
the tablets. The tubes were allowed to
move up and down in the media as 29- 32
cycles per minute in water media
maintained at 37C. Time required to
pass all tablets through the mesh is
determined as its disintegration time.
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Evaluation of Dosage
Form
Weight variation : For carrying
out this test, 20 tablets were taken
randomly and weighed. The
average weight was calculated,
and then each tablet was weighed
individually and their weights
were compared with the average
weight.
Friability Tablet hardness is not absolute
indicator of strength since some formulations,
when compressed into hard tablet tend to cap
on attrition, losing their crown positions. Six
weighed tablets were place in friabilator and
operated for 4 min at 25 rpm. The tablets were
made free from dust and reweighed. The %
friability is determined as difference in weight
*100. The acceptable limit of friability is less
than 1%.
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