ABSTRACT

Background: Intraoral radiography is a low Linear Energy Transfer (LET)

radiation. Parotid gland is a largest salivary gland that most likely being exposed
during an intraoral radiography exposure. The Radiation could risen the
Malondialdehyde (MDA)s level that formed from a lipid peroxidation
Antioxidant is needed in order to protect the cell from damaging. Spirulina
platensis contains antioxidants that can perform as an immunomodulator.
Purpose: Determine the effectiveness of Spirulina platensis in decreasing the
MDA level of rats parotid gland that will be irradiate with a low LET ray.
Materials and Methods: 28 rats divided into 4 groups. Group K1 was a control
group, Spirulina was given for 5 days to K2 (15mg/kg), K3 (30mg/kg), K4
(60mg/kg). Day 6 the entire groups being irradiated 14 times. On the same day all
groups were euthanized and performed parotid gland excisions, soon the parotid
gland specimen was prepared with a thiobarbituric acid methods. The use of this
specimen was to measure the MDA level by using a spectrophotometer. The data
was analyzed by using Shapiro-Wilk and One-Way ANOVA test. Results: 15mg/kg
(4,963 ug/mL 0.7742) and 30 mg/kg (4,449 ug/mL 0.7484) intake of Spirulina
platensis in rats was able to reduce the level of MDA but not significant. 60 mg/kg
dosage of Spirulina was significantly reduced MDA level (3,483 ug/mL 0.3635).
Conclusion: 60mg/kg intake of Spirulina platensis has the most effective impact
in lowering MDA in the rats parotid gland.

Keywords: Spirulina platensis, Malondialdehyde, parotid gland, irradiation, low

LET ray.

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