Aims and Objectives

4. AIM AND OBJECTIVES

AIM: To formulate and evaluate Adapalene loaded

niosomal gel for topical delivery.

OBJECTIVES:
To prepare Adapalene loaded niosomes by
Modified Ethanol Injection (MEI) method using
non ionic surfactant (Span 60).

To establish pre- formulation studies of drug,

polymer, and other excipients to establish their
suitability and compatability.

To investigate the effects of independent variables

on the dependent variable by 32 factorial design
approach.

Physicochemical characterization of optimized

formulations.

To study In-vitro release characteristics

performance on dialysis membrane of optimized
batch of niosomal dispersion.

BVDU, PCP, Dept. of Pharmaceutics, 2014-15 47

 Aims and Objectives

To prepare Adapalene loaded niosomal gel from

optimized batch with suitable gelling agent.

To study the Viscosity study of prepared adapalene

loaded niosomal gel.

To study in- vitro release characteristic and ex vivo

permeation study of prepared adapalene loaded
niosomal gel on Wistar rat skin.

To study the skin irritation study of prepared

adapalene loaded niosomal gel on Wistar rats skin.

To study the skin deposition study of prepared

adapalene loaded niosomal gel on Wistar rat skin.

To carry out stability studies for 1 month at room

temperature (25C 5C) and at freeze condition (4C)
of prepared adapalene loaded niosomal dispersion and
gel.

BVDU, PCP, Dept. of Pharmaceutics, 2014-15 48