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1. OSTEOPOROSIS
2. RICKETS
3. OSTEOMALACIA
4. HYPERPARATHYROIDISM
5. PAGETS DISEASE
OSTEOPOROSIS IS:
THE MOST COMMON FORM OF METABOLIC BONE
DISEASE 15 % 19 %
THE MOST IMPORTANT CAUSE OF ELDERLY 19 %
FRACTURE, ESPECIALLY IN WOMEN
46 %
IN USA:
22 million adults osteoporosis per year
> 1,5 million osteoporosis fracture per year. Other
Expected will be 4x increase in 2050 Vertebral
Spine and hip fracture are most common Hip
Wrist
The cumulative life time risk of having an
osteoporotic fracture : = 3 : 1.
3250
EPIDEMIOLOGY In 2050, Asia
will have
3,25 million
Hip fracture
PREDICTION OF HIP FRACTURE PREVALENCE
Total of Hip fracture
668
estimation per 1000s
742
400
378
600
629
1950 2050
1950 2050
Total of Hip fracture:
1950 = 1,66 juta
2050 = 6,26 juta 100 1950 2050
1950 2050
400
350
person-years)
300
250
200
150
100
50
0
60-69 70-79 80 and older
Unable to walk
80%
independently
Permanent
Death disability 40%
within
one year 30%
20%
TYPES
PRIMARY:
Type I :Postmenopausal osteoporosis (50 to 65 years)
o Due to decrease Estrogen;
o Affects spine and wrist
Type 2 :Seniele osteoporosis (65years and above)
o Induced by smoking, alcohol, less intake of calcium,
o White ras, thin, less activity
o Affects hip and spine
SECONDARY:
Caused by hormonal (hyperthyroid, hyperparathyroid, corticosteroid,
hypogonadism), multiple myeloma, malnutrition, chronic renal failure,
medications or disuses (immobilization due to stroke or casting,
weightlessness)
PATHOGENESIS
CHANGES IN:
Dietary intake of Calcium and Vitamin D
Activity musculoskeletal function
Genetic determinants
Systemic factors :
Calcitonin
Vit D3
Parathyroid hormone (PTH)
Estrogen
Local factors:
Cytokines
Growth factors
Peptide prostaglandine
are important factors in both formation and resorption of bone in men and
women, resulting in OSTEOPOROSIS
PATHOGENESIS
Bone is alive and must be able to grow, heal, and respond to its
environment: BONE REMODELING
The balance between bone resorption and bone deposition is
determined by the activities of OSTEOCLASTS and OSTEOBLASTS,
which are from two different origins.
Osteoclasts are activated first, leading to bone resorption. Then,
after a brief reversal phase, during which the resorption pit is
occupied by osteoblasts precursors, bone formation begins as
progressive waves of osteoblasts form and lay down fresh bone
matrix
PATHOGENESIS
PATHOGENESIS
Normal bone remodeling
Activation Osteoblast
precursors
Osteoclasts
Resorption
by osteoclasts Reversal
Osteoblasts
Osteocyte
Resting Formation
PATHOGENESIS
RANKL
(RANK LIGAND) RANK
Heredity Inactivity
Hormonal Diet
Diet Vitamin D
Exercise
Secondary
causes
rd th
PATHOGENESIS
FACTORS
AFFECTING
BONE MASS &
BONE LOSS
20
DIAGNOSIS
CLINICAL SYMPTOMS
OSTEOPOROSIS IS A SILENT DISEASE: The loss of the bone
mass occurred slowly and progressively for years without
any symptom (thief in the night) and manifest clinically as
fractures with minimal trauma
gb
DIAGNOSIS
CLINICAL PREDICTION OF OSTEOPOROSIS
Bone and joint pain:
snapshot pain in the back
followed by muscle stiffness
is the result of a micro trabeculair fracture
Deformity:
Kyphosis (Dowagers hump)
Varus knees
Loss of Height
Bone fracture:
Fracture with minimal trauma in Spine (T12-L1), Hip (Neck &
trochanter) and Wrist
DIAGNOSIS
Radiographic diagnosis:
X-rays:
Rarefaction of all bones
Thin cortices
Deformity especially in vertebral bodies
DEXA: dual energy X-ray absorptiometry:
The # risk doubles with every decrease of standard
deviation in BMD T-score
Laboratorium:
The serum calcium, phosphorus, and alkaline phosphatase are
normal
X-RAY DIAGNOSIS
OSTEOPENIA IS NOT DETECTED ON CONVENTIONAL RADIOGRAPH
UNTIL 20 TO 40% BONE MASS HAS BEEN LOST
Normal
Mild
Severe
Radiography is inadequate when used alone for diagnosing osteoporosis in
women without vertebral fractures.
Osteoporosis
Normal Osteopenia
0 1 2 2.5
T-score
SD = standard deviation
ESTIMATING RISK of FRACTURE DIAGNOSIS
BMD
Low BMD is considered a major predictor of fracture risk.
An individuals fracture risk approximately doubles for each
standard deviation (SD) of BMD below baseline
SD = standard deviation
ESTIMATING RISK of FRACTURE DIAGNOSIS
BMD
ESTIMATING RISK of FRACTURE DIAGNOSIS
30
25
Rate of 20
27.3
Hip Fracture/
1000 15
Woman-Years 14.7
10 9.4
5
5
3-4 Number of
0 0-2 Risk Factors
Lowest Third Middle Third Highest Third
Bone Density
Co-morbid factors
In addition to preliminary tests (serum calcium, full blood-count,
TSH and kidney and liver function) the following tests were
performed:
Condition Test/signs
42
MANAGEMENT OF OSTEOPOROSIS
BASED ON ACCURACY OF THE DIAGNOSIS, SEVERITY OF DISEASE, AND
THE REGIMEN STRATEGY
Treatment combines:
nutrition
exercise
safety measures
medications
orthopaedic procedures
The main purpose is to prevent the further bone loss and the
possibility of pathological fractures and to build up the bone
deposition: Healthy lifestyle since childhood
NON-DRUG TREATMENT
EXERCISES
SAFETY MEASURES
3. CALCITONIN: Decreasing the oclasts number and activity. Reduce the risk
of osteoporotic fracture up to 57 %. Usefull as osteoporotic pain
treatment.
2 gr/day orally
Modalities :
Brace and support
Casting
Surgical intervention
Rehabilition programs
49
IF FRACTURES OCCURED: Osteoporosis management
GOALS OF THERAPY :
HEALTHY
LIFESTYLE
SINCE
CHILDHOOD
51
Thank you
52
RICKETS
(decrease calcification of
growing bone matrix in children)
GENERALIZED REACTIONS of ALL BONE as AN ORGAN
Bone deposition < bone resorption (generalized decrease in bone)
o in children: Rickets
o in adults : Osteomalacia
DEFINITION
Lack of sunlight (sunlight induce the production of Vit D from the skin)
Hereditary
Vitamin D3 metabolism
PATHOGENESIS
Ca Reabsorption
(kidney)
Ca absorption
Ca PTH Vit D3 (gut) Ca
CALCITONIN
Bone
resorption
(bone)
PATHOGENESIS
Bone tenderness
Muscle weakness
Tetany or convulsion due to hypocalcemia in early stages
Dental problems
Growth disturbance and bone deformity as small stature,
craniotabes, genu varum, genu valgum, pelvic deformity,
kyphoscoliosis or lumbar lordosis, square skull
Greenstick fractures
SIGNS AND SYMPTOMS
SIGNS AND SYMPTOMS
DIAGNOSIS
71
OSTEOMALACIA
(decrease calcification of
mature bone matrix in adults)
=rickets in adults
GENERALIZED REACTIONS of ALL BONE as AN ORGAN
o in children: Rickets
o in adults : Osteomalacia
DEFINITION
Generalized disease of mature bone (ADULT RICKETS)
characterized by softening of the bones caused by defective
mineralization or calcification (CALCIUM SALTS
MINERALIZATION FAILURE which is occured in the organic
bone matrix / osteoid), secondary to:
RADIOLOGICAL APPEARANCES:
Pseudofractures also called Looser's zones.
Protrusio acetabuli, a hip joint disorder
Technetium bone scan
Bone biopsy
TREATMENT
OSTEOMALACIA
decreased decreased elevated elevated soft bones
AND RICKETS
OSTEITIS
FIBROSA elevated decreased elevated elevated brown tumors
CYSTICA
variable
PAGET'S
(depending abnormal bone
DISEASE OF unaffected unaffected unaffected
on stage of architecture
BONE
disease)
Thank you
81
HYPERPARATHYROIDISM
(PARATHYROID OSTEODYSTROPHY)
(OSTEITIS FIBROSA CYSTICA)
(general osteoporosis combined
with a disseminated osteolytic
lesions)
DEFINITION
Increased serum PTH causes hypercalcemia and hypophosphatemia
due to increased bone resorption (PARATHYROID
OSTEODYSTROPHY)
Parathyroid hyperplasia
Bone Scan:
may be negative
Laboratory:
Elevated serum PTH and alkaline phosphatase
Secondary hyperparathyroidism:
Directed to underlying chronic renal insufficiency or intestinal
malabsorption
Vit D high dose
Parathyroidectomy
Thank you
89
PAGETS DISEASE
(OSTEITIS DEFORMANS)
(osteolytic followed by
osteosclerotic phase)
DEFINITION
Slow but progressive disorder that can result in enlarged and misshapen
bones. The pelvis, femur, lower limb, vertebrae and skull are the most
commonly affected bones.
An unknown etiology:
thought that a slow virus affecting osteoclasts
Hereditary: Mutations in two genes, SQSTM1 and
RANK, and specific regions of chromosome 5 and 6
are involved in regulating the function of osteoclasts
in Paget's disease of bone.
Second most common bone disease after osteoporosis
More common in Caucasian, aged > 55 years
Male : Female = 3 : 2
in 4 stages: PATHOGENESIS
1. Osteoclastic activity: an advancing lytic wedge in long
bones or the skull (osteoporosis circumscripta)
4. Malignant degeneration
SIGNS and SYMPTOMS
Laboratorium:
Elevated serum Alkaline Phosphatase
X-ray:
Skeletal survey
99