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Acid Neutralizing Capacity of An Antacid
Acid Neutralizing Capacity of An Antacid
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Objectives
1. After completing this laboratory investigation, the student will be able to determine the acid
neutralizing capacity of an antacid.
2. After completing this laboratory investigation, the student will be able to compare the acid
neutralizing capacity of various antacids.
Procedure
1. Choose 4 antacids to investigate. Record their names and the names and amounts of the active
ingredients in each.
2. Use a ring stand with the double burette clamp and two burettes to set up the titration
apparatus. Label one burette acid and the other base. Place a 250 mL beaker under each
burette tip.
3. Add 5-10 mL of 0.15 M HCl to the acid burette to rinse the burette and drain into the 250 mL
beaker. Complete the same process with the base burette using the unknown concentration of
NaOH. Discard the acid and base.
4. Obtain an antacid tablet and measure its mass and record in the data table. Using a mortar and
pestle, crush the antacid tablet.
5. Place a clean 125 mL Erlenmeyer flask on the electronic balance and zero or tare the balance.
Add approximately 0.25 grams of the antacid tablet to the 125 mL Erlenmeyer flask and record
the mass added to the flask in the data table.
6. Fill the acid burette with the 0.15 M HCl carefully until the acid is above the zero mark.
Dispense acid from the burette into a discard beaker until all air is removed from the burette tip
and the level of acid is within the graduated portion of the burette. Record the burette level as
the initial burette reading of HCl. Use the bottom of the meniscus for your burette level
reading. Complete the same process with the base burette using the 0.2 M NaOH.
7. Into the 125 mL Erlenmeyer flask containing the powdered antacid, dispense approximately 25
mL of the acid. Add approximately 50 mL of deionized water and 3-5 drops of phenolphthalein
solution to the flask and swirl to mix. Let stand for 10 minutes.
8. Titrate slowly by adding the base into the flask containing the acid with stirring until a pink color
starts to persist in the beaker. Decrease the flow of base to a slow drop by drop process and
continue until the pink color persists for more than a few seconds.
9. If you overshoot the titration endpoint, slowly add acid drop by drop until the pink color
disappears. Then add base again drop by drop until a faint pink color persists. Repeat this
titration process until one drop of base will cause the faint pink color to remain.
10. Record the final acid and base burette readings in the data table.
11. Repeat steps 1-9 with three more different antacids.
Name_______________________________________ Date_______________
Data Table
Molarity of HCl solution __________________ Molarity of NaOH solution _________________
Mass of antacid
tablet (g)
Mass of antacid
added to flask (g)
Initial burette
reading for HCl (mL)
Final burette
reading for HCl (mL)
Initial burette
reading for NaOH
(mL)
Final burette
reading for NaOH
(mL)
Data Analysis
1. Calculate the volume of HCl dispensed and NaOH required from each trial and place in the
calculations table.
2. Using the molarity formula, calculate the moles of HCl dispensed in each trial and place in the
calculations table.
3. Calculate the moles of HCl neutralized by the antacid.
4. Calculate the neutralizing capacity of the antacid per gram of antacid.
5. Calculate the neutralizing capacity of the antacid per tablet of the antacid.
Name_______________________________________ Date_______________
Calculations Table
Antacid 1 Antacid 2 Antacid 3 Antacid 4
Volume of HCl
dispensed (mL)
Volume of NaOH
required (mL)
Moles of HCl
dispensed
Moles of NaOH
required
Moles of HCl
neutralized by
antacid
Neutralizing capacity
of antacid per gram
(moles HCl
neutralized/ g
antacid)
Neutralizing capacity
of antacid per tablet
Conclusions
1. Which antacid neutralized the most acid per gram of antacid tablet?
3. Identify a method to calculate the mass of base neutralized, calculate the amount of base
neutralized, and compare it to the manufacturers value.
4. Compare any claims by the labels on the acids like extra strength or maximum strength to
your results for the antacids tested. Do these terms match your results?