Reconnaissance Table

Foreign Review of Related Literature

Author Title Year Locale Method Conclusion Recommendation

Oliver Aloe Vera Gel 2012 Florida, USA Experimental In conclusion, NA
Grundmann, Research the use of aloe
BPharm,ms,PHD Review vera gel or its
An overview of components for
its clinical uses the treatment of
and proposed a variety of
mechanisms of conditions and
action diseases needs
further clinical
evidence through
well-designed
studies with
defined aloe
extracts and
matching
placebo controls.
Currently (June
2012), 5 national
and international
clinical studies
are listed by the
United States
National
Institutes of
Health clinical
trial database
with a major
emphasis on the
use of aloe vera
 in the treatment
of wounds.122
This indicates
the scientific
significance of
aloe vera gel and
the need to
establish it as a
valid treatment
option for
wounds.
However, the
use of aloe vera
gel in topical
applications has
widely been
confirmed in the
clinical studies
as safe.
Robert H. Davis, The Conductor - 2000 Stanford, Experimental Aloe vera
Ph.D. Orchestra California contains
Concept polysaccharides
Of Aloe Vera that act as a
conductor to
direct biological
activities among
an
orchestra of
various
molecules. Many
agents within
Aloe have been
isolated,
identified and
demonstrated to
synergize with
one another over
a large biological
spectrum. A
standard
preparation of
Aloe vera with a
well-defined unit
for each
biological
activity is
necessary for
future
research. The
conductor-
orchestra theory
opposes the idea
that suggests that
one molecule in
Aloe
(a
polysaccharide)
is responsible for
the beneficial
effects and that
the
standardization
should be
based on that
polysaccharide.
A greater
 understanding
between the
conductor and
orchestra is
needed to better
define how Aloe
vera synergizes
its many
activities. This
understanding
will
change many
pharmacologic
concepts in the
future. The
conductor-
orchestra
concept will be
practiced as the
central format by
which the Aloe
industry will
operate.
Wendell D. Aloe Medicinal 2005 Texas, USA Experimental In conclusion,
Winters Substances while numerous
medicinal Aloe
remedies have
been proven to
folk medicine
satisfactions by
time and usage,
without any
scientific reason
 behind why or
how they work,
current scientific
studies are being
directed to
identify and
understand the
operational
mechanisms of
action of Aloe
substances. Such
studies, when
completed,
promise to even
further expand
the potential
usages and
biomedical
applications of
Aloe.
Lawrence The Healing 1998 Cambridge, Experimental From all the In the future
Plaskett, B.A., Properties Of England, United foregoing, it can Newsletter, it
Ph.D., C.Chem., Aloe Vera Kingdom be seen that the will be possible
F.R.I.C. mechanisms of to consider ways
the healing in which the
action are multi- three prime
factorial. That known actions of
is to say, they Aloe work in
are the result of a concert, not only
good many with each other,
factors coming but also with the
together and known secondary
exerting their effects of Aloe,
 own distinct to
influences produce
simultaneously, important
to produce the beneficial effects
overall effects. upon chronic
The knowledge illness. It also
which has been becomes possible
gathered is to address the
impressive, question, as to
though it falls which medical
short of conditions which
complete have not yet been
explanation or subjected to
complete medical trials
understanding. with Aloe,
Nonetheless, it most stand to
serves to give a benefit, on
fair mental theoretical and
image of the inferential
types of grounds, from
processes that the future
are going on application of the
when Aloe therapeutic
exerts its effects. effects of Aloe.
J. E. Crewe, Whole Leaf 1937 Minnesota Experimental The fresh leaves
M.D Aloe Vera and the Aloes
The External ointment and the
Use Of Aloes powder appear to
have the
following
properties:
They relieve
pain, burning
 and itching.

1. They have
some sort of
antiseptic action.
Infected lesions
quickly become
clean and exude
little or
no pus.

2. They seem to
stimulate rapid
granulation and
formation of new
tissue so that
denuded areas
appear
to heal more
rapidly than with
other agents.
They are
effective in
eliminating the
foul odors that
accompany
infection of
broken down
carcinomas,
ulcers and so
forth.
Gianfranco Enhancement of 2013 USA Experimental Aloe vera is a
Pintus Anti- well-known
Inflammatory commercial
Activity of Aloe crop; however,
vera only a few
Adventitious metabolomic
Root Extracts approaches have
through the been applied to
Alteration of it. In this study,
Primary and based on an
Secondary optimized cell
Metabolites via culture system
Salicylic Acid for Aloe vera,
Elicitation we showed that
SA elicitation
led to activation
of the tricyclic
aromatic
quinone
biosynthesis
pathway and the
accumulation of
secondary
metabolites.
Moreover, the
extracts from
SA-treated Aloe
vera had
enhanced anti-
inflammatory
activity in UVB-
treated mouse
skin cells. Taken
together, these
results provide a
 possible
biological
function of
quinones related
to SA-dependent
defense
responses and
reveal the
potential of SA-
induced
metabolites as
chemopreventive
agents.
Dr. Amar ALOE VERA: A 2007 India Qualitative Aloe vera is a
Surjushe SHORT natural product
REVIEW that is now a day
frequently used
in the field of
cosmetology.
Though there are
various
indications for
its use,
controlled trials
are needed to
determine its real
efficacy. The
aloe vera plant,
its properties,
mechanism of
action and
clinical uses are
briefly reviewed
 in this article.
Meika Foster, Evaluation of the 2011 India Qualitative Despite its long Analysis of the
Duncan Hunter, Nutritional and history of use, potential efficacy
and Samir Metabolic there remains a of Aloe vera in
Samman. Effects of Aloe lack of the treatment of
vera consistent particular
scientific disorders is
evidence to complicated by
support many of differences in
the therapeutic Aloe vera
claims for Aloe preparations,
vera. Evidence their means of
of efficacy is administration,
strongest for the and the animal
laxative effects model or study
of Aloe vera design employed
latex, however, in individual
whether the latex studies. Research
is more on standardized
efficacious than methodological
conventional quality is,
laxative therefore, needed
treatments has to identify which
not yet been Aloe vera
determined, and components,
the individually or in
anthraquinones combination,
in the latex are exhibit
associated with therapeutic
considerable properties and
risks. The topical the exact
application of mechanisms by
Aloe vera gel is which they act.
 likely safe and Controlled in
demonstrates vivo toxicology
overall efficacy and safety
in healing burn studies of Aloe
wounds, whereas vera preparations
some promising in humans are
preliminary also required.
evidence
suggests that the
oral use of the
gel may have
beneficial effects
in lowering
blood glucose
levels in type 2
DM, stabilizing
metastatic
cancer, and
treating mild to
moderate
ulcerative colitis.
Further research
in humans is
required to
confirm these
effects.
Urmeela Crude Aloe vera 2015 Moka, Mauritius Qualitative Therefore, the
Taukoorah and Gel Shows present in vitro
M. Fawzi Antioxidant study has
Mahomoodally Propensities and provided sound
Inhibits scientific footing
Pancreatic to enhance
Lipase and assurance on the
 Glucose traditional
Movement In remedy of Aloe
Vitro vera, which may
be efficient as a
preventive agent
in the
pathogenesis of
some diseases. It
is anticipated
that data
amassed in the
present study
will open new
avenues for the
development of
potential drugs
that can be used
to treat and/or
manage DM,
obesity, and
related
complications.
André O’Reilly Green Clay and 2013 USA Experimental In this study, the
Beringhs, Julia Aloe Vera Peel- parameters that
Macedo Rosa, Off Facial most affect the
Hellen Karine Masks: desirable
Stulzer, Rosane Response characteristics of
Maria Budal, Surface peel-off facial
and Diva Methodology masks were
Sonaglio Applied to the investigated. It
Formulation was observed
Design that cereal
alcohol had a
significant effect
on the drying
time. The
applicability of
the formulations
was considerably
influenced by
both the
carbomer and
PVA
concentrations as
a result of their
ability to alter
the formulation
viscosity. The
film-forming
performance was
only influenced
by the PVA
concentration.
The optimized
formulation of
the peel-off
facial mask was
mathematically
determined as
that containing
13% (w/w)
PVA, 10%
(w/w) cereal
alcohol, with no
addition of
carbomer,
achieving high
levels of
applicability and
film-forming
performance and
the shortest
possible drying
time. The
preliminary
stability study
indicated that the
optimized
formulation is
stable under
normal storage
conditions. The
preservative
demonstrated
efficiency in
avoiding
microbial growth
under the storage
conditions
evaluated
(microbial
charge <1 × 101
CFU/g for both
fungi and
bacteria). The
Response
Surface
Methodology
was found to be
an efficient
statistical tool to
determine the
behavior of
different
compounds and
their
concentrations
based on the
responses
studied, allowing
the investigation
of the optimum
conditions to
produce green
clay and aloe
vera peel-off
facial masks.
This paper
provides
background
information on
the application
of peel-off
formulations as a
vehicle for
several
pharmaceutical
ingredients.