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5127-28-Equations Biopharm PDF
5127-28-Equations Biopharm PDF
Equations/Useful_pharmacokinetic_equ_5127 1
Constant rate infusion Calculated peak
C
C max kmaxt
Plasma concentration (during infusion) e e
k
C 0 1 e k e t
CL
with Cmax* = measured peak, measured at time
t* after the end of the infusion
Vd
D
1 e k e T
Short-term infusion k e T [C k e T
max (C min e )]
Peak (single dose)
Calculated recommended dosing interval
C max(1)
D
CL T
1 e k e T
C max(desired )
ln
Trough (single dose) C min(desired )
T
C min(1) C max(1) e k e T ke
D
1 e k e T 1 e
k e
C max D C max( desired ) k e VT
CL T 1 e k e 1 e
k e T
QH Cl int fu b
ClH = EH QH =
QH Cl int fu b
QH
FH =
Q H Cl int fu b
C in C out
Clren = RBFE = GFR
C in
rate of excretion
Clren =
plasma concentration
Rate of secretion - Rate of reabsorption
Clren = fu GFR
Plasma concentration
Female Clearance
IBW = 45.5 kg + 2.3 kg for each inch over 5ft in
height Dose
Cl
AUC
Obese
ABW = IBW + 0.4*(TBW-IBW) Cl ke Vd
Equations/Useful_pharmacokinetic_equ_5127 3
For One Compartment Body Model
For a single I.V. bolus administration: For multiple I.V. bolus administration:
C0
D D 1 e nke
e ket
V Cn(t )
V 1 e ke
If the dosing
C C0 e k e t at peak: t = 0; at steady state n
involves the use at trough: t =
of I.V. bolus
D 1
administration: C max ss
V ( 1 e ke )
Cmin ss Cmax ss e k e
For a single short-term I.V. infusion: For multiple short-term I.V. infusion at steady state:
D 1 e k eT
Since = t for Cmax
If the dosing
involves the use
Cmax
D
VkeT
1 e k eT Cmax
VkeT 1 e k e
of I.V. infusion:
C e k e ( T )
Cmin Cmax e k e ( T )
C min max
If the dosing
involves a I.V.
Ct
D
VkeT
1 e k et (during infusion) at steady state t , e , t 0 so,
-ket
infusion (more
equations): D k k D
Cpss 0 0 (steady state) remembering k 0 and
VkeT Vke CL T
CL V ke
C F D ka
For a single oral dose: For multiple oral doses:
F D ka e ket ekat
C e ket e k a t
If the dosing
involves oral
V k a k e
V k a ke 1 e k e 1 ek
a
ka
1
administration:
1
t max ln k 1 e k e
k e k a k e t max ln a
ke 1 e k a ka ke