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    Sharon Yiu
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    TLRs recognize pathogens and trigger inflammatory responses. TLRs recognize specific microbial components like lipopolysaccharide, flagellin, viral RNA and DNA. Intracellular sensors also detect pathogens and induce type I interferon responses through pathways involving RIG-I, MDA5, and STING. Additional cytosolic sensors activate the inflammasome and pyroptosis in response to cellular damage or infection.

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    TLRs recognize pathogens and trigger inflammatory responses. TLRs recognize specific microbial components like lipopolysaccharide, flagellin, viral RNA and DNA. Intracellular sensors also detect pathogens and induce type I interferon responses through pathways involving RIG-I, MDA5, and STING. Additional cytosolic sensors activate the inflammasome and pyroptosis in response to cellular damage or infection.

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    6 views1 page

    Notebook PDF

    Uploaded by

    Sharon Yiu
    TLRs recognize pathogens and trigger inflammatory responses. TLRs recognize specific microbial components like lipopolysaccharide, flagellin, viral RNA and DNA. Intracellular sensors also detect pathogens and induce type I interferon responses through pathways involving RIG-I, MDA5, and STING. Additional cytosolic sensors activate the inflammasome and pyroptosis in response to cellular damage or infection.

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    of 1

    carb structure

    Devlin 1×2
    .

    CLR fungal infection


    response
    TLR 112 :
    triacyl inflammatory
    inflammatory response
    :indhfaYdnu,a
    ERR
    36
    " FN
    TIR DSRNA Type
    i '

    TLR : , viral
    inflammatory response
    acid
    TLR 4 : LPs on gram
    -

    nipotechoic gram +

    TLR 5 :
    Flagellin
    TLR 788 viruses I IFN
    :
    Type
    TLR 9 :
    uhmethylated DNA

    MAVS → TRIM 25 -
    RIG 1 →

    CARD cytoplasmic TRAF


    IFN +
    inflammatory
    12 LR 1<63 → → TBK , →

    holicase viral RNA


    1 RF 3 → IFN -

    DNA → 11<13
    →
    NFKB

    Intracellular
    sensor OF NFKB inflammation
    N LR CARD
    bacterial
    µop Rlpz → XIAP → TAKI →
    damage /
    infection NFKB
    ( likelzpbhtinujto )
    infection I
    As 113 ltls
    procaspase
    →
    ( 1L
    -

    → 1

    NLRP PYVM cellular


    caspase , pyroptosis
    damage

    CGAS CHAMP STING


    Cytosolic
    →
    → →
    Type ( IFN

    RNA viral TBKI →


    IRFZ →

    sensor DNA

    DSDNA in
    HW → Asc
    →
    caspasel ihflammasome
    ALR HIN cytosol LLIB 148

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