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  • Basic Immunology

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    Sira Pornsiriprasert
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    1) The document discusses immune cell recruitment and barrier function during pathogen exposure. Neutrophils are recruited to form a barrier, while IL-1 and IL-1β promote Th1 and Th17 responses. 2) Upregulation of IL-6 and TNF leads to increased inflammation and disease, while downregulation of IFNγ and STAT transcription factors inhibits Th1 differentiation. 3) CD4+ T cells can convert between Th1 and Th2 phenotypes depending on cytokine exposure, affecting Ig class switching in B cells and response to helminth infection or allergens.

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    1) The document discusses immune cell recruitment and barrier function during pathogen exposure. Neutrophils are recruited to form a barrier, while IL-1 and IL-1β promote Th1 and Th17 responses. 2) Upregulation of IL-6 and TNF leads to increased inflammation and disease, while downregulation of IFNγ and STAT transcription factors inhibits Th1 differentiation. 3) CD4+ T cells can convert between Th1 and Th2 phenotypes depending on cytokine exposure, affecting Ig class switching in B cells and response to helminth infection or allergens.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    9 views1 page

    Basic Immunology

    Uploaded by

    Sira Pornsiriprasert
    1) The document discusses immune cell recruitment and barrier function during pathogen exposure. Neutrophils are recruited to form a barrier, while IL-1 and IL-1β promote Th1 and Th17 responses. 2) Upregulation of IL-6 and TNF leads to increased inflammation and disease, while downregulation of IFNγ and STAT transcription factors inhibits Th1 differentiation. 3) CD4+ T cells can convert between Th1 and Th2 phenotypes depending on cytokine exposure, affecting Ig class switching in B cells and response to helminth infection or allergens.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

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