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by Dr Devesh Mishra
MBBS, MD , AIIMS
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Rge
< Endothelium
·
D
stabil ↓ G-Anticoagulants ↓
⑰
~Heparin"-like mole."N Thrombomodulin(tm)
A I ↓Struct, change
22.
Natural
"h" AT- -
anticoag
-
"Thrombin
I Thrombin
te Canticoagul
inactivate
Synth
↓
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2
↓
protein/s
liver -
2
#, IX to A
inactiv
& ↓ 2
22.
Trans-
mc Hered.
#
tr Leiden
E
thromb mutation
↓
[A U) thmb
+
Young.
Adults.
Alcoholic Liver Disease
22;Gamma ↓
Harboxylation vit. K-
=
depend. ClotFactors
22.
Glutamate
X
2, 7, 9, 10
-
i 20
coagulation path -
22 I
=1165.
i
Intrinsic:aPTT Extrinsic PT
s
=
Har
·
ll I -> tissue-ing
*
-
-
x
·
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H
Glass, si
#
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thromboplastin
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·
·
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Plastic common
sy
-->
-
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-
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Prothrombin
V
7 Thrombina
Y
"Fibre-be
fibrinogenanilisingt
>
↓
401.
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Factor.
Lines
clot-lysis
↓
↓ 22.
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Pla(i)sminogen
Fibrin"->FDP
Itibgra.e -
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↓
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A ↓
Minor Major
↓ -
Petechine/purpura
=
Al
·
Spont. Hematoma
(muscl)
Skin/ Mucosa. ·
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A (Recurr, jointpains
pH-disord -,
Clot-Factor is
2) PH-count (1.5=4.5 lans/mm]
↓
T
*
2] BT [2-gming
-
-
function of pu
Hemophilia
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A - B
- &
-
·
AR
XR-Mr
·
· Mc
Hemarthrosis.
·
mptom.
I
I
Lab -
I
-PI-cou=N
-
BT M
=
PT M
-
sated
aPTT4 =
Platelet-disorders
-
↓ -
qualitative BT4
20.
quantitative
22. Fun,
=
defect-=
I
H
Plt-count M N
Plt-count =1,e4
2 =
=
22
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BT 4
=
X
Bernard-soulier dis[BSDI
-
1 -
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VWE,
I still he
↓
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quantitative pHdis
Coomb'stest& ana:
Thrombocytopenia
=
b
A ↓ ↓
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· ge A X -
pH-dest TTP HUS
Eg4-
22
⑭ ADAM-TS-13 ↓ ⑭
M-Ts
DIC -> t t
agentinAbam-TSts
a
· Abn-Agg
↓ Typical
-Pedia Atypical
Adult
Prevent 5 Thrombotic
-
theI
Thromboppenin E.coli [0157:H7]
Noalwing-
=>
·PItcount &
-
Abn-pit-Agy. I
·
completo
shigative
-
clot to
·
cr
=> PI 1; BT4 Flow-t
-
↓ factor Ad
t Pit dest
-
, 4: Srfibrinogent, /
ADAMTS 13
↳
-
·
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TTP HUS.
AR >ST AR
-BSD ·
dis.
defect
M P
--
Gpzblsa
Y P2bapIt
⑪11
s
Aggreg
fibrinogene
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a
2
② -
WW
-
- -
Weibel -
Palade
Bodies.
ABO inaut
=> MAG- M-Acetyl--Galactosamine
X 9 > Galactose
H-gene
I9
↓ 11
④2 H-substance
it 2 Y⑰ - ↳
2. I
MAG 4 MAG +9 H
X
A 99
If ↑S
RBC =
A
E
AAg
B
*
Bag. AB
e
---
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k
surface
Y
- X Y
anti-A
Serum - anti B anti-A No-ab
- anti-B.
"A, B,
Secretors.-
Al
H-y.
⑬ RBC-sur
Blende 2
1955
A Virate
Blood p
Bombay
22 22.
#
AR = Ih
11
-gene absent
-
↳
-
Blood 9p
↓
Absent
RBC
-> A, B,
H-ag- requiring transf
22
Non-Secretors a X
from
same old Ip
Serum o anti-A, B, H present.
=
ONLY"
A
-Bombay. blood
⑧
&
Storage temp Shelf-life
whole Blood Als
↓ 2
⑧ -
components
↓
I 256° ·
I 42
days
2] PRBC ↑
↑
I
- contagitation
3] FFP
> 12c or ---
1
yr.
-
y Cryoprecipitate lower
-
Blood
Bag Anz
-
A
Additives 21) Glucose/ Dextrose
Nutrition
to RBC
2.
2) A DI 21d. Buffer.
2) Phosphate->
-
pit
-
↓
2] CPD I
XXXX
maintain
Rec
22.
- chelation
3) Citrate= I of cate
o 3] <PD-A -5days.
=>
> ↓
- clot
batt No
42
tetany -
4 SAGM >
days -
life span.
5) Saline
Maintain
=>
RBL
isotonicity
67 Mannitol
I
prevent hemolysis.
Indications BT
of
1) Whole Blood -> Hypovol. Shock Ium,
Anemia.
2) Packed RBC ->
seeafor factor,
trauma
3] FEP ->
e
a
cryoprecipitate # - Hempt.A
&
VNF >VWD
EIll-.d,
- A fibrinogenia
⑧
fibrinogen
⑧
protocol
Transfusion
↓ 222.
Whole,Blood/PRBC
**
*
the
--
Transfusion Reactions
X I
f
Infections
22.
· MC MCCOD in BT.
extemol y ti c * Al
For
[
2
HIV-1in
-
TRALI * TACO
HCV
Au Transfu Related TransAssoc
=>
HBV
Acute lung in. Overload
->
Cardiac
Malaria
-
Ein "6"
Syphilis, his
·
=>
· cin 12 hrs.
fever -
Tc4
=BN, diuretic
best
BMP
N
q4
BT => > 1 Blood ein 24 his
Massive
-
volume
Al
5L= 10 Blood bags. MBT not alw-
A
complications Art
1
~
KT
Hypothermia, cat
-
feta
are E
↑ catt
=
Metab. Alkalosi's
linersalesas the
A MBT - notalw
AGI bigt
--
4
2+ -
] X
v
- xkt
2
↳Mg2t
ris
DilutionalCoagulopathy
asin the
- Hypothermia
v Metab. Alkalosis.
# Mc-LOD.> in Massive BT
N
Dil.CD
#Fixed component-ratio
⑪
PRBC: "Platelets: Ftp
I :1 e I
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