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Ver

Angi ET Anxi
↑ FAT
Ca P KAME
d L
d

hea Cit Thy


Als mi cef

N
A
A d d
de KIN
Anew

-
All
higher affinity
r FGF2]
Prostatic Fibroblast
Benegn
·

Hyperplasia : stable
-

more
- -

TUFB proti
T

O
Stroma Role of And
Hyperplasia Epi -to death
Epithelial strema - 4
prolifera Test -
> DHT
·
Nodules e with d 4
per canal CTCR
Narrow Kreth FUF-7- ↑ Growth -in
only
·

Stromal
Obst
urinary outflow parassine
· - .

cell

Morp >
- Gross >
-

2-4 times wit

of proximal Wethra
↳ submucosa
↳ nodules
earge compress"
>
-

↳ some
may project upto floor as
hemispheric
mass >
- bemath the mucosa Median labe

↳ hypertrophy)
Multiple nodule out
capsule
.

fluids Predo
glstromayellow-pink honeycombed soft
. I
, ,

fluid i fibromus
pale tough
>
-

gray
no

Mc ↳ Epi cell
-
-
Glands-Layer
~ inner-columnar
(Acini & ductules Louter-unboidal
Papil ary stor in tumen
of g's colum

Corpora amylacea -
in acinileosi concre")


Smooth cell mus +
>Ster fibroblasts

Modules -
Types of > Stromal ,

fiblomus ,
Museu ,
fibroadeno
,
tibromyadeno
other-symp inf ; infarc ; sq .

metap at
edgl-
Complic diverticula (Bladder)
Hypertrophy
-

Cystitis
P
yeloneph
Hydromphrosis .
Markers -
Prostate
-specific Ag CPSA) sameprotes
e
>
-

↳ alls
Secretory
t
prosta
ncn
<feto protein ,


LDH
↳ng(mL

Organ specific BPatitis
density Saum Velocity Isa
PSA SA
Age
-

Bound

Fatic
Acid Phosphatase (PAP -
Epi
↳ Metastasized
↳ Renal liver , Bone
,

E
Krine Marker
>
- PCA
non-coding
- RNA

E
↳ PCA3 A # IMPRSS 2 ERG DNA . Wine
fls
-

-mass of screening
Tx cells & Tx burden .

&UCh -
I non-seminematous GCT (NSGIT)

↳ choriocar
Yolk
Seminoma -
Sac
Syncytio .

GC
.

TX

Importance Mars Burden Therapy


.
>
- ,

Stage ,
,

PLAP
Seminoma e H24 ,
Teratoma e AFP , ncG

Embryonal
YST
-

-
CEA
AFP
choriocar LcG
-
B
-
Gorm cell TX (mal)

E
O
classical ,
anaplastic Spermatocylc
il2p
>
-
.
KIT4 , 0C73/4 ,
NANOG .

spread-
Locat Paren
Rile testis
<

epi di
dymis
Lymph-Abd .
LN

Prognosis
-

Radiosensiti
Mets -

LN

Besprog

Giant all
malGCT ;
germ all
layer ; mature to imm ;
syncytiotroph
d
·
Postpubertal
· somatic

type

-
- x
Carcinoma Breast ->
-

-3 Sub Hormone R
/g major LUER2 muta
·
Genetic -
>
Familial-BRCA1 -
Triple- Sporadic HER2
- +

] TPS
BRCA2

#
Her >
- ER +
Envi TP53 ER + HER + >
- PIKARTY
PTEN BRCA1
Est
BG FC
Inact - T-
mothy
Para &

Daf /autoin e

#
GIIGP A
65
GermBRCA2 PIRBCAeAtd DCIS - E
169
Breast
&

-19
- -

Hyp
-

Normal 20 (Luminal)
>
- Gam TP53 >
- HER24 >
- DUS - HERT

↳ ampli HER erriched .

15
Gem BRCA1 - TP53 -> BRCA1 >
- DIS >
- E-
H-
inac
Basal
-
L
-
-
O -

-
=}
° ° O
* >
-

-
-

-
-

----

- - - -

--
~

>
-
-
- -

/
-
Types
T
/
ox-
· hard sharp
stones Ca o

Pa- Hyper
Cout :
Calcina
calcemia
7050 % #
Tubular
reabs

Blood-black 10 % ->
Hyperpara
=

haemorrhage
oe
RD
Hyperuricosuria nucla" of &

-soft &
Hypersonalis Hereditary .
pale

Struite
(3-Mg NHyPOy) 3 , Hea
splitting bast -
NHy *

Staghorn calculus all


ph ppt
.

>

Pelviscalges at
to e
form

Hard to
Solitary
· Get
hargest
- -
UTI ,

pain bluding Perimphis


, ,
abscess .

Mic Aid & Urate stones :


Hyperuricemia ; rapid cell turnov

↳ insol acidic .
<5 5
<pr
.

in

Radiolucent smooth hard to reddish-brown


yellow
,
,
&

faceled Mulliple
Mullle-
- -

Lamina
"
.

--

Cystine -
>
Cystimia - def reaks
low
PH .

small , round ,
waxy multiple
,

Yellow &
wary
Ro >
-
sulfur
E
d
ML

English main
O easy·
se :
②LL INJURY
& ADAPTATION
P .

CELL
Injury
-
> causes :

d

-b

I
1

I
-

&

Physical InjectionsImme
Hypoca
Chemical

Genetic Nutritional
Aging
Mechanism
② >
-

ell
of Injury
O

earlest
organelle
Mitochondrial
↓ ATP
produc :

inflc oat it
-

damage
I nomeostasis
Accumula" of 02 decined
radicals !
free
↓ ATP

- Anaerobic Detachment
sodium
pump Gegedgies · ribosomes

Gerty I Nat

-
d-
a

Gegeogen
kt
fle
· of ↓
LPH
cat
influx o ↑ Ladie
Acid
I
↳ remote
e

a poten
dirata" of
ER
cell
surling > detach
-
loss of microvilli
ribo
Blebs
radical
Injury
&

1
Effects
Prop so Autocatalytic
saley ·

destroyed ROS ,

Phospholiped
ineff degrada"
.
T
·

produc & syn


↑ PL breakdown
OUT
Types
,

-
-
02°, U202 ,
↳ -
cytoskeletal damage
.
ANOO NO2 -
consequences Mito memb
dan e
,

Prasma

memb
damage
Cel > Vysoso

see
-
es

3
02 H202
Glutathi
120
-
H20
ONOOT Peroxi
↓ NO Catalase

- misfolding
·
Brackdown xidants


esprfr o
SOD
↳ Enz so
~
ROS
>
-
Fat Memb Lap

T
damage
I⑳
&
e
e Mon-End

Vitt
,

EXOT

o radical Meta" break


,
Endo Transfer
Ferritin
Albermin
damg e
is
fett Is culoplasm
is
-
wapony
NADPT

Respiratory
(a

Burst
Pi- U2O2

FetzOu
Rx
On-
La

>
-
o
Fatty change e

Accumula" f
TG Tin

cytosol of parenchymal
cells

Gross
ellow &
soft
greasy .

b
TFFA /Stanc"
& diabete Nice Microvesicular manouesi

Metabolism >
- 4 Signet ring
↳ syn -
Stain-Sedan IV or
Oxida Oil Redo
↳ to
Cl

orange-red
Cosmic
apoproteins &PEM sid
↳Sudan
· Excre" f Black B-Black
Necrosis :-
EJM - amoplious density in mitoch

↳a diges Ik myelin fig

irregulated lysosons disrup


Marp- Cyto
> >
-
cosinop
glassy
moth eaten
Nuclear -
Pinosis-Shrinkage &Basophilic
Karycolysis -
fading disappear diges
,

(glost)
-
Karyohexis -
Fragmental

#
coagulative Liquefactive
outline
solid
preveserve -

eyses
Eschenia organ

Proteolysis X
Pancreatic
End arteries
-

>
- Heart necrosis

leukocytes
Dry firm yellow
, ,
und
-

in
Wedge shaped Kidney & spleen

I I
Tombstone recruited C
2
posit Causes-Embryogenesis Morp -Elme cell Shrinkage n
Nuclear condensa &
fragmenta
Removal of apoptotic Hormonal withdrawal
Blebs &
apoptotic bodies
bodies-phosphatidylserine Phagocytosis
Ab
Phagocytosis ;
;
Tropic Stimuli Saute
Infla)
Thrombospondin
Potentiharmful
al y Calf isI
active
lympho
&

Pathologic

*
> Damaged &NA

O (CD95)
>
-

Misfolded protein
O
g

Viral
· &NA caspase s

23 & 6)

Pathologic atrophy
Parenchymal
Neoplastic cells
·

·
Death-induced

signalling complex
Adapter
Protein

& FLIP
caspase antagonist
Em
INIEL
IN MAA TI OIAD
&
& D
#LIN
·

Acute
n
/ Vascular

Inflamma
L cellular

I
Vascular in & Caliber :
change flow
>
- -

4 Permabilit : -

Vasodila
Fluid RBCs
· protec
-
,
,

permeability
e Interstitium
slowing of
Blood
stasis
·

blood

Histamine PG Kinns
V
Endothelial all
·

, .
contrac
Aubs P

Beadyk

L
---- ,

cellular
extargination ·
Direct endo
injury
Rolling-selective , TNF ,
IL-1 ·

Leukocyte
mediated vascular
fakes"
Integrin
-

euge
C

Injury
low
affinity
>
-

ised transcytosis
·

Transmigrat CD31
·

Leakage e
new

Diapdesis
>
-
PECAM-1 fre
.
vessel

Chemotaxis >
-
Exo-Bast products
Endo-IL-8 ,
LT By
Cra 139

Accumma lenko at sete- Birdto CDU4


of
integrins
TLR GPCR
Phago & opsenisa-> Recog & Attach -
,

Mannose ,
,

Cytokine
R

EnguysPhagoyaLeroso s ,
Grana
Chemical mediators Lights Receptor specific ,
Regulated Dive
: Inter-related
a ;
short-lived
.

rast cell
-
Baso Plt ,

Immune
disata" farteriole , 4
pienab
enterochro
>
-
Pl ,

↳ 2/2 :
PAggregar .

low -
> PH Baso, Mast
VD ;
Leus adhes chemotace PA, ,

Leukocy
v #lu agg & adhei endothe mo
PA III mie
du microbicidal III

↳ activate
md
⑭ ((X3C C
Local effects - Prolifera" o

Fibrobla
&
syn of collagen Killteliva" of
fibrinolytic sys : -

Plasminogen -
Plasmin

ESP- permeabilite
complement sys

Hemorrhage ↑
Jaundice
HEMOD NAMIC chronice


IDA ;
-

S =S -
Acute I

& Amount
Peppe

-
volle

Ruptur Effects
-
Trauma
of aneurysm shock
·

z
Vascular D2 speed
↳ essions site -
inflammatory gotless
Brain -
more
Neoplastic
·

Local >
- -

Remonhagic diathesis E
I venous DVT
Hydrostati
>
-
Raised pressure return
>
-
↳ Postural
·

Press

GaramKeenrot
edema
-
a
e
Edemafldt
Edema
Gen
- -- CHF
-
Righte
Periph
I
edema
,e pitting
Left Pulmona
n
-

Heart
Gen
fail ↓Plasma
-
PEM , liver D z

motif

e infl
as

lym
Serum
Ma ! Th (Pean & orange)
Press/Ty over Thoracic
Damage by surge (Breastf
axilla (N)
Parasite-Pilariaso
Meredi-Milroy's
D2
Cardian


Clinical Gen Sc - Renal/
Mosph-Sc langs , , Brain +
-


Pulmonary

edema

GenesceGravity Pitine ↳
Cerebral Brain sube -

Mynedema foramen magne


-Blood
scrotal ,
periorbital
Papilled ema
) Blood
supply to

Brain
tinged fluid oozing Stem occlud

from ling
- - -

Jinjure
.

Heart-MI
-
Infec Endo
embosse
-

to endo Values -

States) Terbulent
Damage (RHD)
Libman sacks

>
-
Hyper coagulability
Arteries
Acute test
capill -
>
inf
Endo
injury Thrombogenic
-

abn Adhesive
- DIL
to
infl. cells

amer emer ise


HTM , toxin ,
rad"

·
image anit
Mural
! Heart chamber
Hypercagu , artic lumen

- The
Vegeta on heart value

B&
s -

- Fibrin
Varicose
0000Platelet Aneurysm
PV , SCA
lines
of Rahn-
light
- Pt =
fibrin Organisa
Dark Fibrin + RBC

-
-

Mycolic aneurysm
-o

- Physical

(famous
e

Embolismte
- Bland) septic
occlude e ee
alterat
Cardia , I ↓ as clar

- put
·

Multi
· flow recurrent;
-Pate - Resolve" ; Massive Pul embolism , Paradoxical
Consequences Hemorr
Infars"
-
Shock
-
+ CHF , t
eurgDz Saddle
Bifurca o Aute -

Hemorrhagic
Mint effect Pyramidal; pos scar pul artery Rightvertis
O

main
Eat
& Marrow
embling Cause -
-
Trauma to
adipose tissue i
fracto
4

Soft tissue burn

Cardiopulm resuscital

Air Embolism/-Trauma- causes : -

>

surgery
- -

· neck wound

]
-
Comermes - Brain ,
Kidney-systemic ·

injury
Thoracocnt
Chest wall
venous
rungs
-

-
-
coronary °
Obstetric
·

- fat
Autopsy- globules bypass
A
.

Lungs ARDS -

Braine edema criminal abern


hemonhay ,
.

-
Monstra"-
> Frozer sea
hear t
stain
special E

E
Clinical -1 to 3

cardia I
days after
F

Tachypnea ,
Respi fail
-

Restlessness
Irritability
f
,

Thrombocytopena
S
·

O
·
Anemia
Opecifica XRay
· -
Chest .

Chronic Casson Pz-Avascular necrosis


multiple faci of
ischemic necrosis of bone
↳ gemeu tibia humerus
,
,
I
White/Pale Red/remoschagic
·
Asterial occlus O
venous occlus"

solid The density 3 loose textured


-

organs organs
·

blood I
out dual
supply
· &

intestine
Eg Mart
spleen hidney Eg- Quary lung
·
- · , , ,
, , ,

Dry brain

I
Gangrene
Poorly defined slightly hemorrhagic
Sharply
circumscribed
.
·
.

·
Paler light yellow Dark red
purple
.

to
·
,
-
IMMUNITY
=
Hypersensitively
--Sensitiza
Nature
of Ag
Genetic succeptibility CULA
Imbalance blu control &
genes)
Mech effector
of Injury
.
Urticaria
Type-1 t Local-Asthma
Type-1 Hay fewr
,

Penicillin
,

Bee Insect
sys
-

. ,
Sting
Atopic
Allergic Ag)
-

- - -

- -

·
i

⑭ -
B
-

°
-

- -

O
chemota
Drug & Autoimmune
Ag

>
-

Production
a
a
>
=

Drug ind . -C

Ege Autoimmune Hemoly And -

"Thrombocytop purpura
complementAg

e

-~② Be all

by phagocytesthrough
-

opsonizat I by
recognizedGbR
Ec &

E
phagocytes

Ege
Transfers
ic
a
D2 Newbor
Egopasture 130 ,
Ca-Anaphylatoxins
syn

Secpace Recep

Eg Graue Myasthenia
,
Ege Arthus my
SLE

Glamunlrphi
Arthritis
vasulitis-
Eq >
-

Montoux
Graft versus

Leprosy
SLE : -chr .

autoimm - Auloab-V .

Protean manifesta & variable Behaviour


-

Remission
,

& relapse
·

Skin heart
Key Point
.
·

Etiology
>
-

I
.
Genetic-family MLA PR2 DR3 ; ,
impaired removal of
I/C ; apoptotic bodies ; B-ell Tolerance
# FC Rec
Envi-ur ,
cigarette , sex ho , isoniazid
Hydralazine
Immuno-IFNX ,
TLR

Clinical
enology
-&
>
-
--
Young women

Multisys
·

there
face
Butterfly
·

rash
ou ,

plewulio
-

fer ,
cust

photosensele
y -

pain
I
,

Lab >
-
course
I FA
;
Diag
ELISA
; Ado
effec
;
ESR : CBC
Renal Hemateria
-

Lemat-Anemia

LE Bodies
>
- Damaged damaged
all nuclei
react !
And e homogenes
(LE .
all)
engulf by phagocyt
other aPL Anticardialpin
-
- ;
Lupus Anticoagulant Ab ;

anti-B2 glycoprotein . I
/c infect Tx allograft
,

-
E
MHC >
- ULA on & 6p MH 2 1= ULA -A ,
C , B

Highly polymorphic

·
⑰ [Dg

organ Expt (R eatrophio)


· Trample #>- HLA DP & R
B, Dend
Langer
Mono , ,

B27)
D2-
Ankyes endoch
Autoimm spondy O
< HLA
(DR)
CDY

MHC #I
hemochro Complement) INF
,
Inherited
Mereditary
-

matosis CLA As cytokines

E
Transplant Rejections Guest by Most P8 &
<

Graff APCs
AR ,

by then Talks .

CDy-Tus

canotic mottled flaccid fibrinoid

Renal
failure
Diagnosis of HIV = AIDs :

·
ELISA >
- Sensitive

Nestern- Specific/cai
·

e
· P27 Aydet
·
DNA PCR
·
Culture

E
- ↳
#

E
-S


E
·

- >
E
E ↳
-

C °

> CMU ·
US V -
VZu
E

>
>
- >
-
E - M

fibrillars
Amyloidosis
Genft Forms
protein Physical-
>
-
>
-
>
-
Inherited &
infl
·

Non-branchin
- -
.

misfoldin
·

El fibrillary protein
deposits
·

B pleated
tht
·

charged agae geps


·

polypeptide
g Bioply kidnig Congo
D dyss
-
-
red

Gingival Apple green


Abd
fat aspirate Bifringence
.
·

Mim & serem Chemical-95%-Fibril


electroph & 57
Proteoglyc
.

immer
GAGs
scintigraphy CSAP)
·

Serum
Any P
Biochemical >
-

I
MinerSTTR
Major
:
:
-
-

Clinical-Gl
O

transport Thyrosine
·

cardiac
O

&
relinof
A L
2 amyeod ligh
indivi-Heart
chain of Eg
Penal
Aged
·

Plasma cells
van
specific produced by
&

⑭Ma Hemodiales ~


other
⑰ - A .
associated

Non-sy
Drived
from ,
SA

Chr
Infl (20)
-

⑭ Amy
30 Precisa

protein
-

Transmemb GP
Cerebral les"f
Alz D2
Maphology
>
-

1 Respi Liver
Organs
Heart G1 :
Kidney
>
- >
- 2 -
, ,

Perip Adel

Nerve
splen
then
tongue Lymph &
nade

Thyrord &

↳oss
> ape
-

Iodine Fellow
L

Sulphuric
aced
- Blue
volet
O

/ - n &E
-Amaphous casciophilic hylanine glary
, ,
, ,
EC
Pressure
elemply
congo-eed polarising MK apple Bi
-
pink-red ;
-

green
van
Gieson Khaki
-

Alcian blues Blur


&
Methyl
PAS
creage violet-
>
Ross
Pink
Punk
O
-

Iodine
Mahogany
>
- brow -
HseyBluevat
This
flavin T -
Florescence
It ATTR
staining >
- ,
AA
,
AL
distinguish .

rommon
Kidney spleen-Segosfolledartaio
- Most
severe
Shrunken
Lardaceous RP
·
, wall of sinuses >
-
·

Glome /Mesan Mati


of reddish
2BM Mapcolor
-
like area

capillary narrowing Liver-space


·

of Disse
Peritubal
O

arteries
Semle Prese
Hart-Systemic , ,
Step
.
others Macroglossia
NEOPLASIA

Lymphatic

-
characteristics- >

PN of spread -
en
_ Benign
Differentian Lmalignant Subcaperar since >
- entire LN -

Sentine
LN

Anaplasia
n
.
Lack
of diff Skip mets
Virchow-suprac Abd
.
-

+ >
-

abn
↳ Preomorp
Retrograde Prostate
Nuclear
Hyperchromatic : Mitoses ;
i >
- -

morp
coarsely clumped
- -

meloi Hemat -
prominent >

N: Ostro RCC, chario


Cratio i Loss Necrosis &
f ; Growth Giant , ,

; i
polarity Pattern
cells
Apoptosis capillaries & venules
-

Rateof
Growth-Degree f diff

Polym nuc
HCC
Blood -2hyperchLiver &
-

Dependency & Her


lang - M/C
Balcine /u product los Bone-
> Verlebeal -
col.
Ben ↳ ostro eucent
Local ly
>
-

open
metse

z
Mal eng
ostbl -
>
dense
Prost Breast ,

ALPT

/
·

Seeding of Body airty&


surfaces >
-

E
-

Transcoelamic -orgadjto
body carity evary -
al

lung
Glioblasto

Epi lined >


-
Endomet-
spaces

Me
ovary

mapant Kidney
is contr
Invas" Met cascade · Invas" of EKmatrix
-
-

·
Mets (vascular dissemina" &
homing of
TX alls) .

-
I Cancer >
Hallmarks
·
↑ TVC M
↓- VC
A
·

all war metabolism R


·
Los of apoptotic plu A
·
Loss of replication senescence Mz
Fangiogenesis
·

Growth of micro-macro
·
Invade & mets
4
angiogenesis Evasion of host imm
resp
·

↑ -

Classifica" o onco-

GFSPDGFB Astrocytoma
GFR-EGFR ERBB1 Adenocar of
eung
signal a RRAS
Pancrease Color
transduc & rung
a

L
protein
Gene
locus
>
- e. .
B. Nuclear
Reg MYC Burkitt
Reactiva" protein/ >
-
NMYL Neurobla
e

Mphase Transcrip"ft
activators

se enaa
Germ-Retine
Cell
cycle cycling
regulatorCDK
DI MM

Osteosar DKY Glioblast


Acqe S
Gliobl

cry
Viral - F
F
- of HPV
TP53
->
-
17p13 Non-stressed >
- MDM2
colon , breast ↓
eung Stud MBM2# Es URL
ee
Gate L ↓

Molecular Policeman p534 p53 toub


&

psi degra
-
Inactiva" -Acq
Germ - LiFraumeni
MDM2 muta
EG HPV
O
-

Etiology
- -
>
- Chemical
Microbial
Rad

Chemical -
Microbial >
-
-

Breast
Sex Blood jeed
<Dy T 4** &
TAXgene - GMCs
F44#p53 ↓
No onco can't
integrate

HPV
virus

Burkitt
EBY -
> Burkitt ,
B ,
HL ,
MP ,

Gastric African
·
childhood .

#g -
Lytic Productive - death -
.
other
·

Malaria-inadequ
Immortaliza
Latent
2
>
-

viral
- cell
suppress
gener
-
cytok ↳ Bell 44 -

LMP1 EBNA2 VILLO ·

EBV (B all)
↓ to

Transcript LMPL eliminated
& prevent
NF-RB & o
Cycling actival ·

JAK-STAT
c- MYC C +; 8; 14)
SRC - cells
family by ↳
Lymphoma
.
d
Bell see & L prozo-onco md

proliferale
-
Lab D
-Morphological
: : -

Histopath Clinical data: -

142 :
Categorise undiff
-

Adequate representative area

origin
.
Proper
fixa
"

Frozen sec :
de
-

Tissue hardened rapidly by Progri


I cut sec
Rapid dg freezing by
Evalua
o margin freezing microtome/cryostat Neuroendo-chramgramin
Demonstera" of fat synaptop
NSE
Additional workup
.

Sentinel LN
Inade tissue soft tissue _
vimentin
↑ sample Sarcoma
Despres
G

- Needle
Endoscopy
core Gl
Incision Excision Glial
Cell-Glial
needle inoperable) Breast neo
Resp too fibrillary
Acidic
use large Poten

Cytological

-

Exfoliative -

Etm-Poorly diff
Invas FNAC small bore needle Flow

E
-

-
class of Txo
Indivisud Liquid based
to -
&B
early alls

disadv

Bob
Histo & Fro
did
IUC
Cytochem -

·
BM & PAS
collagen
Glycogen
F
-

"Idiastose
Musin
Mucicarmina
-

↓ ↓
Enz- MPO
FNAC
Cyto How Em
En
ALL L-small home ; incospicuous nuclea
Large 1 2
variable
"

12 size
-
-

homo
L3-
Large i
finely stipled chromatin ,
prominent nucledi .

minimal
diffe =

L
AML >
- O
I Tout
-n
malura
cytochem
2 i matura MPO HG02- Brown
granules
-

Promyelocytic

Myeloid series

:
*

Myelomano Sudan Black B - PL-Black


Mono
Lipid &

Erythro Myeloid

·
.

Megakaryo Non-specific Esteras - dark red


cyto granules
>
-
ALLE
Peri Blood : -


Monocytes

109/ Periodic sird x


WBC < 20 -
200 x
schiff ·
Glycogen
Lymphoblast train

Pl > d
d

↓ Blacks of PASt d
Hb >
-
↑ colorless schiff
mer Erythroid sto d
RBC -

Normo-Norma M7 Bright red-pint


>
imagenta
-

WBCe > 20 %
Lymphob
d
Neutrophil Alkaline Blue &
Phosphatase
agr large smally granular
than
e ↓
Baso

cyto Nucleoli-nt Preg , Down
condensed chron Propenia, leukemoid "
,
PV
↓> PNH CML
hem- PAS+
,
>

-
Immunophenot
>
- Tot +

hemical >
- Wi Frid ,
LDH4
⑭ Peri Blood --
NBC >
- 20100 x 109/L
Hb >
- ↓

Peri Smear-RBC-N-N
WBC -
3-s
times
large than small lym
Cytochem-Mycop & SBB
Fine nu .
Ch .

2-4 chali
NBE - Mono
>
cy to
than
lymp
All rods I
azurop medl like
peroxide +

-
Myelopo
=F

neo of us a

chimeric of BCR-ABLI
jus"
·

gener
·
Ph & it 9:
20short) - oncopotio - T ->
growth It
ABL1 BCR signalling Phu -

·
HS

Chronic
-2-6yrs
HbG
VA
RBC-NIN
Blast < 10 %
;
Shift to
left LDH

FISH
B & E UNAP
P/t4 >
Lea blue
Dary (Gancher (
histiocytes
Acc >
-
Myelob
B
> 10-19% Beast - dete len &
poor pro
Blast-207
PH > d
PH d
-
Peri blood-HbL TLCA of med to
Nodular agg large
Lymphescant cyto lympho Moor
"Smar-NIN ; a
Immuno
19
20523
nucli-clumped
coarse chroma
Phenot Csocce
smudge/basket .
all
ball/block-type)
⑭M-protein in
serunfueine
new
of BM

nuclear &
Lacunar cell
variant

⑳e
· O
I
Mummified Anaplastic)
Pleomormphic LP(Pop)

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