Home Fentanyl Synthesis

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Thread: Home Fentanyl Synthesis
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02-10-2006 03:35 AM #1
Samcastic
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Default Home Fentanyl Synthesis
SWIM ran across this, searched the forums here for it, didn't see it, so
he's posting it here for anyone who is savvy enough...
Drone's home-made fentanyl analog!
Yep, drone has doen what was thought impossible, and

will now divulge what is thought unmentionable,
because DRONE #342 is DRONE #342, and can do that!
Folks, have you ever had a hankering for a big, juicy

ounce or two of synthetic heroin, but just thought it
impossible to allocate the necessary chemicals? Well,
your friend drone has taken out the guesswork and
managed to develope a synthetic route to a chemical
1000 or so stronger than conventional smack.
Impossible, you say? NAY, my dear worker bees.
Here's the general overview of fentanyl synthesis.

4-piperidone is reacted with a trimethyliodo
(quaternary) salt of a phenethylamine (or any number
of aromatic ethylamines), to produce an
N-arylethylpiperidone (you can use the quaternary salt
of the piperidone with the primary substituted
arylethytlamine, if you like, too.) Anyways, this is
reacted with aniline, and reduced with NaBH4, and then
reacted with propionic anhydride to produce the
fentanyl freebase.
It turns out:
*adding an ethyl carbon bridge to the piperidine ring

will not reduce potency.
*adding an extra methyl to the phenethyl substituent

to make a phenylisopropyl makes for a strong,
long-lasting compound.
*adding a hydroxy to the alpha-carbon of the pehethyl

side chain -- as seen in ephedrine -- will also
increase potency.
*as I said in a previous post, propionic anhydride can

be made at home (this is the most closely watched
chemical on the DEA's list, but this watching was
rendered obsolete by YoursTruly not too long ago.)
The Fentanyl Suite, in d(l)-major; Movement 1
(the curtain rises, our anti-hero is found quietly

sauntering through the woods, foraging for
precursors.)
Taking this into account, Atropine is extracted from

nightshade. It is hydrolyzed to form tropine. Tropine
is oxidized to form tropinone. Tropinone is then
exhaustively methylated with iodomethane.
Second Movement
Dexatrim is bought in a fiendish quantity. The PPA is

extracted and isolated as its free base. This is
combined with tropinone, to form
N-(1-hydroxy-1-phenyl)isopropyl tropinone.
(intermezzeo)
Third Movement
Aniline is combined with the aforementioned

freshly-made tropinone, and reduced with NaBH4.
Fourth Movement
(Allegro)
Propionic anhydride is made from a propionate salt

like calcium propionate by adding bromine or even
chlorine. Alternatively, propionate esters are
hydrolyzed, the acid component isolated, and combined
with acetic anhydride and allowed to reflux, with the
product being fractionally distilled.
(crescendo)
The propionic anhydride is added to our soon-to-be

fentanyl analog compound, and allowed to react (I
think around 50 C). The product is flash
chromatographed, combined with citric acid (or any
acid of your choice), and allowed to dry.
The material is cut with hundreds of times its mass of

mannitol.
Viola! China white has just been made out of

Nightshade, diet tablets, aniline, and food
preservatives. It's all there in the literature. Ref's
available upon request.
Are we having fun yet?
-drone #342
Reply With Quote Reply With Quote

02-10-2006 11:08 AM #2
Mokelly
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Default Re: Home Fentanyl Synthesis

someone do this now! (Bogumil?) and send product to me for quality
assurance testing.....
All of the above is false.

02-10-2006 08:21 PM #3
exitwound
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dang! Somehow I doubt that anyone with the resources and equipment would
risk such a ghetto synth.....but hell, if it works, it works!
"I hate to advocate drugs, alcohol, violence, or insanity to anyone, but

they've always worked for me." - The Good Doctor, Hunter S. Thompson

02-10-2006 09:15 PM #4
caesee
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ok, guess I just flush the kilo of o I was going to use o make h, and go
with this..lol:D

02-10-2006 10:19 PM #5
exitwound
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LMAO! Yeah, who needs opium when you have ghetto fentanyl made from deadly
nightshade! LOL :D
"I hate to advocate drugs, alcohol, violence, or insanity to anyone, but

they've always worked for me." - The Good Doctor, Hunter S. Thompson

09-24-2006 10:03 PM #6
tophatgr
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Hey Guys...I am new, and aced Chem 1 in college, IQ 191 and have a several
engineering degrees.
Think I can systhesize some FA?
I want to develop a detailed procedure for this, step by freaking tiny
step, listing every piece of equipment and labwear, how and where to get all the
precusors (nightshade, dexatrim, sodium propionate).
All Who Participate Will Be Compensated! We will share the wealth.
This is a SERIOUS PROPOSAL....REMEMBER THAT THIS IS FOR THE DEVELOPMENT OF
THE PROCEDURE ONLY AND IS NOT INTENDED TO BE ACTUALLY USED...:D
Let us start with complete, detailed lab procedure steps for the following
modules:
1) PPA(Phenylpropanolamine) free base extraction from Dexatrim tablets.
This procdeure needs detailing.
2) Extraction and purification of Atropine from Nightshade
==>hydrolyzation==>oxydation==>methylation (iodomethane)==>tropinone (or can
atropine be bought? Sched IV drug - so I don't think so...) the plant is only found
in a few areas of the USA, can it be bought at nurseries? This procdeure needs
detailing.
3) Propionic anhydride synthesis: Calcium propionate + Br ==> Propionic
anhydride This procdeure needs detailing.
4) Obtaining Aniline: Is it a monitored chemical? I don't think so as it is
used in dye production.
What specific type of aniline is required for this process?
5) Aniline + tropinone, then reduced with NaBH4. This procdeure needs
detailing.
6) Details of the flash chromatographing operation used to separate the
product. What is the citric acid used for? Recomendations on the type and brand of
unit are needed.
__________________________________________________ ______________

Drone's home-made fentanyl analog!
Yep, drone has doen what was thought impossible, and

will now divulge what is thought unmentionable,
because DRONE #342 is DRONE #342, and can do that!
Folks, have you ever had a hankering for a big, juicy

ounce or two of synthetic heroin, but just thought it
impossible to allocate the necessary chemicals? Well,
your friend drone has taken out the guesswork and
managed to develope a synthetic route to a chemical
1000 or so stronger than conventional smack.
Impossible, you say? NAY, my dear worker bees.
Here's the general overview of fentanyl synthesis.

4-piperidone is reacted with a trimethyliodo
(quaternary) salt of a phenethylamine (or any number
of aromatic ethylamines), to produce an
N-arylethylpiperidone (you can use the quaternary salt
of the piperidone with the primary substituted
arylethytlamine, if you like, too.) Anyways, this is
reacted with aniline, and reduced with NaBH4, and then
reacted with propionic anhydride to produce the
fentanyl freebase.
It turns out:
*adding an ethyl carbon bridge to the piperidine ring

will not reduce potency.
*adding an extra methyl to the phenethyl substituent

to make a phenylisopropyl makes for a strong,
long-lasting compound.
*adding a hydroxy to the alpha-carbon of the pehethyl

side chain -- as seen in ephedrine -- will also
increase potency.
*as I said in a previous post, propionic anhydride can

be made at home (this is the most closely watched
chemical on the DEA's list, but this watching was
rendered obsolete by YoursTruly not too long ago.)
The Fentanyl Suite, in d(l)-major; Movement 1
(the curtain rises, our anti-hero is found quietly

sauntering through the woods, foraging for
precursors.)

Second Movement
Dexatrim is bought in a fiendish quantity. The PPA is
extracted and isolated as its free base. This is
combined with tropinone, to form
N-(1-hydroxy-1-phenyl)isopropyl tropinone.
(intermezzeo)
Third Movement
Aniline is combined with the aforementioned

freshly-made tropinone, and reduced with NaBH4.
Fourth Movement
(Allegro)
Propionic anhydride is made from a propionate salt

like calcium propionate by adding bromine or even
chlorine. Alternatively, propionate esters are
hydrolyzed, the acid component isolated, and combined
with acetic anhydride and allowed to reflux, with the
product being fractionally distilled.
(crescendo)
The propionic anhydride is added to our soon-to-be

fentanyl analog compound, and allowed to react (I
think around 50 C). The product is flash
chromatographed, combined with citric acid (or any
acid of your choice), and allowed to dry.
The material is cut with hundreds of times its mass of

mannitol.
Viola! China white has just been made out of

Nightshade, diet tablets, aniline, and food
preservatives. It's all there in the literature. Ref's
available upon request.
Are we having fun yet?
-drone #342[/quote]

09-24-2006 10:16 PM #7
trainwrecker
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Well, I know Bitter sweet night shade grows all over here (Pacific North
West) I would be willing to collect a bunch and make it available to anyone who
pays for shipping.

09-24-2006 10:46 PM #8
EndRun
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Quote Originally Posted by tophatgr View Post

(or can atropine be bought? Sched IV drug - so I don't think so...)
I thought atropine was in immodium? Or is that only in the prescription
version (lomotil, me thinks?) If it's in immodium, I assume it'd be much easier to
get from here than to pull from nighshade. But then, my chem degree came free with
a bundle of smack, so what do I know?
"Even the weariest river winds somewhere safe to sea"

09-25-2006 12:25 AM #9
superman
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"All Who Participate Will Be Compensated! We will share the wealth.

This is a SERIOUS PROPOSAL...."
first of all, to propose something like this makes you sound like a cop. to
say you're a chemist, and a genius, and looking for people to help you make
fentanyl...... now that's just stupid.
besides these points, you're on the wrong forum for this kind of shit. it's
not secure, it's not chemistry oriented, and it's not going to be much help (unless
you're looking for some suckers to throw in jail)

09-25-2006 01:07 AM #10
chemboy7
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Yeah, superman's right that kinda sounds like there would be an exchange of
an illegal substance and this is strictly forbidden. There's alittle chemistry talk
around here, not too much though; this is a forum that get's into sythesis alot
more/indepth (although they seem to be down at the moment)
https://www.synthetikal.com/
I'm not too sure that Atropine is a controlled substance either, in the
medication Lomotil it is schedualed but that is due to the Diphenoxylate not the
Atropine. The Atropine is in there to prevent abuse and thus the low schedual (or
high I guess); I bet that Diphenoxylate by itself would be a much lower schedual. I
know of at least one chemical supply house that currently advertises Atropine HCL
in it's cateloge... whether or not they have it in stock is another matter though,
if you had your email addy up I could send it along but I won't post it publically
and you don't have PM ability yet.
And this is the second time in a week that someone has dropped their IQ on
us... that's just weird.

09-25-2006 05:00 AM #11
devilsdrug
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yea 191 no less shit that is signifigant what % does that fall in yikes
09-25-2006 05:17 AM #12
RobOC
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Oh yea! Well my IQ is so high all I have to do is think about fent and

WHAMO, it exists. Who needs ghetto synthesis when your a super genius with
psychokinetic powers?
You say you're down on your luck.

Hey baby it's long, long way up.
Hold back now, hold back your fears.
You say you're really down and out.
And you feel like there's no way out now.
Let go now, let go of your tears.
-"Angels Wings" by Social Distortion. Fuckin' Mike Ness,

09-25-2006 08:32 AM #13
antony
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I wanna know when we had to start posting our IQs.
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09-25-2006 10:50 AM #14
nick
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Peeps have already started posting their IQ's.So when it feels right go for
it Antony.

09-25-2006 02:55 PM #15
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thanks, nick. I'll retake the test when I'm finished writing up my American
Scientific Journal article on how I recently discovered and produced dark matter.
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09-25-2006 06:46 PM #16
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the atropine is easy to get.....the dexatrim now.....thats hard,

but ChRIST theres a million steps......i remeber some parkinsons
breakthrough occured becuse some jackass was only 10 degrees off on a snthetic
fentanyl recipie.. it made some brain-mushifying compound form in the batch, and
then a bunch of junkies were zombies within a week. really helped scientists
understand how parkinsons fucks the brain up tho...those 20 junkies are still
getting poked and proded ......
This is really cool, and there must be a way to make homeade opiates...but
this recipie lacks details, and way to many steps....without yeild...and from my
experince atropine s a fragile chemical that breaks down easy. the final yeild must
be like .02% lol

09-25-2006 08:59 PM #17
chemboy7
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Quote Originally Posted by northernstar View Post

the atropine is easy to get.....the dexatrim now.....thats hard,
but ChRIST theres a million steps......i remeber some parkinsons
breakthrough occured becuse some jackass was only 10 degrees off on a snthetic
fentanyl recipie.. it made some brain-mushifying compound form in the batch, and
then a bunch of junkies were zombies within a week. really helped scientists
understand how parkinsons fucks the brain up tho...those 20 junkies are still
getting poked and proded ......
This is really cool, and there must be a way to make homeade opiates...but
this recipie lacks details, and way to many steps....without yeild...and from my
experince atropine s a fragile chemical that breaks down easy. the final yeild must
be like .02% lol
It was the Meperidine analoge MPPP that was the goal of the synthesis in
question, it ended up being tainted with MPTP; which is the compound that caused
the instant Parkinson's-like symptoms and subsequently all the ruckus.

09-26-2006 11:50 AM #18
Hammilton
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Actually Diphenoxylate is C2. It's pretty enjoyable stuff. It's a cogener

of meperidine I believe.
your mileage may vary.

09-26-2006 05:48 PM #19
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[quote=chemboy7;43117]It was the Meperidine analoge MPPP that was the goal
of the synthesis in question, it ended up being tainted with MPTP; which is the
compound that caused the instant Parkinson's-like symptoms and subsequently all the
ruckus.[/quote}
ahh, thanks chemboy!

the important thing i remembered was that it all happened becuse of a 10
degree screwup in the cooking....home ghetto synth can have tempatures all over the
place from lack of real lab equipment. it seems dogey to me, yet doable too in a
way becuse atropine is gettable..in almost any quantity one would want...

09-26-2006 09:42 PM #20
john_doe
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In one of the recipes above it says to acquire DEXATRIM tablets. But they
took those off the market so good luck finding that unless you live in Brazil or
some crazy country like that. Nothing against brazil but you guys are crazy!
Fentanyl synth is going to be more and more common in the future. People in America
are going to start learning it and doing it. I think it's already begun. In mexico
they could make this shit and pump it into the U.S and canada easily and it's very
cheap to make and a good high very strong. but along with this comes unexperienced
chemists and they will probably not dilute it right or cut it right and end up
killing alot of people. people dont know how to handle fentanyl either they always
asusme it's just good white heroin and shoot it up and they end up in a coma. I
heard of a group of users in the U.S who were shooting up and they found them all
dead in a circle. I think it was 8 people but i may be wrong. Apparently they all
died from a fentanyl overdose. Not plain Fentanyl i think it was alpha methyl or
methyl fentanyl i'm not sure of the name.

09-28-2006 09:25 AM #21
bonkers
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Damn, why's chemistry gotta be so damn complicated? I just want some fent,
I'm not trying to win a Nobel prize for science. Jeez...

09-28-2006 09:49 AM #22
nick
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Wasn't that guy trying to make fent in Calafornia when he turned people
into statues?

09-28-2006 11:12 AM #23
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Quote Originally Posted by nick View Post

Wasn't that guy trying to make fent in Calafornia when he turned people
into statues?
No.. From Page 1, of this thread, entry #17
Quote Originally Posted by chemboy7 View Post

It was the Meperidine analoge MPPP that was the goal of the synthesis in
question, it ended up being tainted with MPTP; which is the compound that caused
the instant Parkinson's-like symptoms and subsequently all the ruckus.
..jab

09-28-2006 09:52 PM #24
superman
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"In one of the recipes above it says to acquire DEXATRIM tablets. "
that's odd... isn't dexatrim just dextroamphetamine?the only usefull thing
someone would make with this is methamphetamine but it's not even worth the effort.

10-02-2006 02:24 AM #25
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Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's

really an odd social habit to post your IQ and your college grades.
Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it.
I'm interested in this idea, but it doesn't seem to be a "home" thing.
You're talking about fractional distillation. I think that's inherently not

a "home" process. If we had fractional distillers everywhere, LSD would be just
easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out
of em.
Also, we're talking about working with phenethylamines - which are

basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be
got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very
regulated.
I wish it were possible, but it would probably be a much easier thing to

become an amateur botanist rather than an amateur chemist - grow one's own poppies
and harvest opium and then make heroin.
Like it was mentioned: the %yield will probably be tiny for us amateur
chemists without access to professional lab equipment and pure precursors. Also,
there is no detailed info on reactions (I doubt these all work out fine at Room
Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you
might end up with a mess of white gook of which 1% is some random-ass fentanyl
analogue and the other 99% is SodiumBromatoic acid or whatever.
I just don't know about drone #342, but I wish it were good enough to be
true. I think it's easier to be a social-engineer than a chemical-engineer and go
doctor-shopping. However much I love chem, I'm still only going to stick to the
easiest of reactions for now.

10-02-2006 11:41 AM #26
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Quote Originally Posted by BorisB View Post

Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's
really an odd social habit to post your IQ and your college grades.
Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it.
I'm interested in this idea, but it doesn't seem to be a "home" thing.
You're talking about fractional distillation. I think that's inherently not

a "home" process. If we had fractional distillers everywhere, LSD would be just
easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out
of em.
Also, we're talking about working with phenethylamines - which are

basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be
got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very
regulated.
I wish it were possible, but it would probably be a much easier thing to

become an amateur botanist rather than an amateur chemist - grow one's own poppies
and harvest opium and then make heroin.
Like it was mentioned: the %yield will probably be tiny for us amateur
chemists without access to professional lab equipment and pure precursors. Also,
there is no detailed info on reactions (I doubt these all work out fine at Room
Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you
might end up with a mess of white gook of which 1% is some random-ass fentanyl
analogue and the other 99% is SodiumBromatoic acid or whatever.
I just don't know about drone #342, but I wish it were good enough to be
true. I think it's easier to be a social-engineer than a chemical-engineer and go
doctor-shopping. However much I love chem, I'm still only going to stick to the
easiest of reactions for now.
I agree with you about this being a "dodgy" recipie, but about the
fractional diastillation....its used in the refineing of oil, and in principle
seems simple....altho prob misleading. What do they use in a O-chem lab to do this?
Could someone build a fractional still at home.....diffrent chemicals sublimate at
different tempatures, and are collected at different points in the colum, lowest to
highest i belive.....

10-02-2006 11:08 PM #27
superman
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fractional distillation at home is definately do-able, even more so if

you're willing to using google to find out how to do it. the only roadblock is the
effort required to know how to build the apparatus, which in some cases is very
simple, and in other quite the opposite.
there are countless drugs that can be made at home, but i suggest anyone
wanting to be a clandestine chemist learn to use search engines and find a strictly
chem forum for support. if you want help with extractions and other basic things,
you should be able to get the advice here (unless you didn't use the search engine
first).

10-29-2006 05:53 AM #28
surreal
surreal is offline
Occasionally Opiated surreal is an unknown quantity at this point
Join Date
Oct 2006
Location
Interzone / Black Forrest
Posts
52
Hey all,
new here, just wanted to add my 2 cents to this as it's one of my favourit
themes :)
Dexatrim is, as far as i know only required as a source for
Phenylpropanolamin, which is, banned now almost everywhere in "the western world".
Don't know about the rest.
Also i remember that drone's synth wasn't to be without controversy,

regarding the details and the practical doability - at least it should be pretty
impossible to perform without real good theoretical and practical chemical
background.
But there should be other ways if one is stearleggy enough.
- none the less drone was a real genius - his name shall be praised in
eternity :)

11-04-2008 06:49 PM #29
chemchem
chemchem is offline
Occasionally Opiated chemchem is an unknown quantity at this point
Join Date
Dec 2007
Posts
35
my understanding is that tropine is taking place of the piperidone, and PPA

replaces phenethyl-Br.
Now, my question is if anyone knows why it must be a quaternary salt?
I'm thinking of methylating piperidone and then reacting it with

phenethylamine?
I'll have to look into it more but this could be a feasible idea to get
NPP.
Edit: I'm having a real hard time seeing this reaction. He said either one
can be the quaternary salt and react with the other, but how does this reaction
occur and what is the side product?
Last edited by chemchem; 11-04-2008 at 07:14 PM.

11-04-2008 08:01 PM #30
robojunkie
Guest
As someone who actually knows what I am talking about, drone 342 is likely
full of feces, and this would be best used to grow poppies, not synth fent. Very
derivative procedure written by a creative guy with some knowledge of the
structures, but one could only react the atropinonen with the exhaustively
methylated (what he called the trimethy iodo salt of alpha whatever phenethylamine)
quat amine salt of PEA/PPA/amp. And by the way, doing it a more creative way one
can use amp to make AMF. This procedure may be actually doable in theory but not
the way he says.
I call self serving trollish bullshit on drone 342. The queen (or king) bee
probably sacrificed his ass after that post...
Oh yeah, a quarternary amine is positively charged so its a goood leaving

group. The secondary amine of tropinone then attacks with its "lone pair" at the
alpha methyl and kicks the trimethyamino group the fuck out. Since the once
tropinone has a hydrogen that is easily lost, the reaction is irreversible, as
alkly groups (from the trimethyl iodo salt) aren't easily exchanged the same way.
For all of you guys who really want to know this stuff the best place to
look is the college bookstore and pick up Ege or McMurry or Streetweiser Organic
chem texts, then maybe March or another Advanced Organic text. Then you can figure
out all thewhys and hows as well as nail the bullshit as it steams.
+ Reply to Thread
� systhesis of N-Phenethyl-Piperidone (NPP) | Propionyl Chloride! �
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org - euphorization for the inebrianation

Registrations are currently closed, however we open it up periodically every

Drone's home-made fentanyl analog!

Yep, drone has doen what was thought impossible, and

Folks, have you ever had a hankering for a big, juicy

Here's the general overview of fentanyl synthesis.

*adding an ethyl carbon bridge to the piperidine ring

*adding an extra methyl to the phenethyl substituent

*adding a hydroxy to the alpha-carbon of the pehethyl

*as I said in a previous post, propionic anhydride can

The Fentanyl Suite, in d(l)-major; Movement 1

(the curtain rises, our anti-hero is found quietly

Taking this into account, Atropine is extracted from

Dexatrim is bought in a fiendish quantity. The PPA is

Aniline is combined with the aforementioned

Propionic anhydride is made from a propionate salt

The propionic anhydride is added to our soon-to-be

The material is cut with hundreds of times its mass of

Viola! China white has just been made out of

Are we having fun yet?

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All of the above is false.

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"I hate to advocate drugs, alcohol, violence, or insanity to anyone, but

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Default Re: Home Fentanyl Synthesis

"I hate to advocate drugs, alcohol, violence, or insanity to anyone, but

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Default Re: Home Fentanyl Synthesis

Taking this into account, Atropine is extracted from

Drone's home-made fentanyl analog!

Yep, drone has doen what was thought impossible, and

Folks, have you ever had a hankering for a big, juicy

Here's the general overview of fentanyl synthesis.

*adding an ethyl carbon bridge to the piperidine ring

*adding an extra methyl to the phenethyl substituent

*adding a hydroxy to the alpha-carbon of the pehethyl

*as I said in a previous post, propionic anhydride can

The Fentanyl Suite, in d(l)-major; Movement 1

(the curtain rises, our anti-hero is found quietly

Taking this into account, Atropine is extracted from

Aniline is combined with the aforementioned

Propionic anhydride is made from a propionate salt

The propionic anhydride is added to our soon-to-be

The material is cut with hundreds of times its mass of

Viola! China white has just been made out of

Are we having fun yet?

Reply With Quote Reply With Quote

Default Re: Home Fentanyl Synthesis

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Default Re: Home Fentanyl Synthesis

Quote Originally Posted by tophatgr View Post

"Even the weariest river winds somewhere safe to sea"

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"All Who Participate Will Be Compensated! We will share the wealth.

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