Sistem Penghantar Obat

Pendahuluan

Septiawan Adi Nugroho

Fakultas Farmasi

Institut Ilmu Kesehatan Bhakti Wiyata

Definisi
• A drug delivery system (DDS) is defined as a formulation or
a device that enables the introduction of a therapeutic
substance in the body and improves its efficacy and safety
by controlling the rate, time, and place of release of drugs in
the body
• This process includes the administration of the therapeutic
product, the release of the active ingredients by the product,
and the ubsequent transport of the active ingredients across
the biological membranes to the site of action.
Aspek Dalam Penghantaran Obat
• Spatial placement
Penghantaran obat dengan target spesifik organ atau jaringan.
• Temporal Placement
Penghantarn obat dengan mengatur ritme dan waktu
pelepasan obat pada target jaringan
Rute Penghantaran obat
Desain penghantaran obat baru
• Sustained Release Oral Dosage Form
• Sustained Release Injectable Dosage Forms
• Sustained Release Topical Dosage Forms
• Implants And Iuds
• Transdermal Drug Delivery System (TDDS)
• Targeted Delivery Systems
• Liposomes
• Nanoparticles
• Polymers
• Monoclonal Antibodies
• Transmucosal Drug Delivery Systems
• Inhalation Systems
• Buccal Delivery
• Rectal Delivery
• Vaginal Delivery
• Ocular Delivery
• Vaccines
• Polyclonal Antibodies
Aims of DDS Devolepment
Number of new molecular entities Number of publications on controlled
coming to the market in last decade drug delivery systems over the years
Perbedaan :
• Extended release ?
• Delayed/prolong release ?
• Repeat Action ?
• Targeted release?