Arup Chakraborty

Guided by:Mr. Nilanjan Sarkar

 The conventional dosage forms provide drug release
immediately and it causes fluctuation of drug level in
blood depending upon dosage form.

 Therefore to maintain the drug concentration within

therapeutically effective range need novel drug delivery
system.
 “Novel Drug delivery System (NDDS) refers to the
approaches, formulations, technologies, and systems for
transporting a pharmaceutical compound in the body as
needed to safely achieve its desired therapeutic effects.
Advantages of NDDS
 Optimum dose at the right time and right location.
 Efficient use of expensive drugs, excipients and reduction
in production cost.
 Beneficial to patients, better therapy, improved comfort
and standard of living.
 SR – Release of initial dose & further prolonged
release of drug. Also called extended release, delayed
release, prolonged release. SR means slow release of a
drug substance from a dosage form to maintain
therapeutic response for extended period (8-12hrs).
Time depends on dosage form. e.g., Aspirin SR Tablet,
Zuclopenthixol Depot Injection etc.

 CR – Release of drug in controlled release for long

periods. In this the rate or speed at which the drug is
released is controlled. e.g., Adalat CR (Nifidipine).
 Physicochemical properties of a drug
 Route of administration
 Acute / Chronic therapy
 Target sites
 The Patient
 The disease state/level
1.Matrix Diffusion Types-
◦ Rigid Matrix Diffusion.
◦ Swellable Matrix Diffusion
◦ Reservoir System
2.Dissolution Matrix Type-
◦ Encapsulation
3.Dissolution & Diffusion Controlled Release
System
4. Water penetration/Osmotic Pressure
Controlled NDDS
5.Chemically controlled NDDS
 Nanosomes
 Liposomes
 Niosomes
 Nanoparticle
 Nanosphere
 Microsphere
 Microparticle
 Microemulsion
 Nanosuspension
 Micelles
• Diabetes is a disorder related to the deficiency in the secretion or
action of insulin - a peptide hormone synthesized by the β cells of
islets of pancreas.
• Insulin is given by the subcutaneous (SC) route. Patient non-
compliance is frequent with the SC route.
• To remove the hurdle related to oral insulin delivery various efforts
have been made. Thus, oral insulin is a dream of patients.
• Nanocarriers have been garnering more attention recently because
of their size in nano range and greater surface area. These
characteristics improve their absorption in contrast to bigger
carriers. These novel formulations improve bioavailability;
absorption problems associated with insulin and give protection
from enzymatic degradation.
• At present, researchers from both industries as well as academics
are working on oral insulin. With this struggle, the dream of
researcher to deliver insulin orally will turn out to be a reality in
the future.
• Nanotechnology plays a significant role in drug
development.
• As carriers, polymeric nanoparticles can deliver vaccine
antigens, proteins, and drugs to the desired site of action.
• Nonmaterial's are widely used in vaccine delivery systems
because nanomaterials can make the vaccine antigen long-
acting.
• Some biodegradable polymer materials such as natural
polymeric nanomaterials, chemically synthesized polymer
materials, and biosynthesized polymeric materials, and
points out the advantages and the direction of research on
degradable polymeric materials.
• Polymer-based nanomaterials have great potential for the
development of novel vaccines and drug systems for certain
needs, including single-dose and needle-free deliveries of
vaccine antigens and drugs in the future.