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Prepared by: Dr. Ridwan Olawale MBBS, MSc., PhD. Research Fellow in Tropical
Medicine @ African College of Health, Abuja. Nigeria
olawaleR.A04/14/2018
Advances have been made through expanded interventions delivered through five public health
approaches: innovative and intensified disease management; preventive chemotherapy; vector
ecology and management; veterinary public health services; and the provision of safe water,
sanitation and hygiene. In 2015 alone nearly one billion people were treated for at least one
disease and significant gains were achieved in relieving the symptoms and consequences of
diseases for which effective tools are scarce; important reductions were achieved in the number
of new cases of sleeping sickness, of visceral leishmaniasis in South-East Asia and also of Buruli
ulcer.
The report also considers vector control strategies and discusses the importance of the draft
WHO Global Vector Control Response 2017–2030. It argues that veterinary public health
requires a multifaceted approach across the human–animal interface as well as a multisectoral
programme of work to protect and improve the physical, mental and social well-being of
humans, including veterinary, water, sanitation and hygiene.
Integration of activities and interventions into broader health systems is crucial, and despite
challenges, has the potential to accelerate progress towards universal health coverage while
advancing the 2030 Agenda. In short, this report drives the message home that “no one must be
left behind”. (who.int)
We are highly honored at Waleson Medical Limited (African College of Health’s mother
company) for another opportunity to prepare a pattern of approach towards ‘Control and
Elimination of Neglected Tropical Diseases’.
We are registered in Nigeria (RC; 937009) for the purpose(s) of Medical Research, Training and
Consulting. Most of our past activities revolves around education (basic/advance) into core-
clinical issues as well as public awareness information dissemination in topics related to Tropical
Medicine (NTDS inclusive). We have, in the past 7 years, presented varieties of Tropical
Medicine related works to organizations both foreign and local. Basically presented in forms of
infection control strategies to FMOH (Nig), EBRAP (DoD), CDC and to name a few.
At this point in time, it is very clear that the USAID supported ‘WHO’s 2020’ initial plan of
approach to ‘Control and Elimination of Neglected Tropical Diseases’ has almost reached
Documentation/Elimination stage. We are definitely prepared more than any other firm to be
involved in the ongoing acceleration phase works. Putting in mind that our organization was also
partially a party to Proof of Concept and Expansion stages, that stands an assurance that we are
ready to take part in the delivery of expertise as at when required towards achieving complete
elimination or at least a reduction to the lowest level of Tropical Diseases surges.
Our driving force is motored by our online heath education platform; African College of Health,
a British Council Online Member School. Established in the year 2013 with the aim of educating
the world (displaced people mostly) in matters related to Tropical Diseases, NTDs and others.
We have presented works covering regions within Element one and Element two. The fact
remains that; although online information dissemination knows no boundary, we tend to
function better within Element two countries.
Our major challenge for years remains lack of funding from both local and foreign organizations
but that does not stand a chance in stopping our educational and research activities into diseases
within the scope of most prevalent NTDs (LF, trachoma, schistosomiasis, onchocerciasis, and
three soil-transmitted helminths: Ascaris, Trichuris, and Hookworm).
Our expenditures in the last five years are at the range of $500,000 to $1000,000 per annum.
Meaning that we are indebted to community-based organizations that they themselves have no
support from neither government agencies nor NGOs.
Preventing and controlling NTDs is central to ending extreme poverty in the next two
decades. USAID’s NTD program supports the achievement of broader development goals, such
as USAID’s overarching goal of ending extreme poverty and the Sustainable Development Goals
(SDGs), including SDG1, to end poverty in all of its forms, and SDG3, to ensure healthy lives
and promote well-being for all, which includes ending NTDs by 2030.
Seven of the most prevalent NTDs (LF, trachoma, schistosomiasis, onchocerciasis, and three
soil-transmitted helminths: Ascaris, Trichuris, and Hookworm) can be targeted through a highly
effective integrated community treatment approach using drugs that have been proven safe and
effective, and which can be delivered by trained non-health personnel. This approach, known as
Mass Drug Administration (MDA), provides a single dose medication to all eligible individuals
in an affected community generally once or twice a year. When implemented without
interruption over three to seven years, MDA can significantly control the burden of NTDs, and,
in some cases, their elimination can be achieved.
Neglected Tropical Diseases (NTDs) are communicable diseases linked with poverty and
prevalent in areas with poor sanitation, inadequate safe water supply and substandard housing
conditions.
The NTDs are estimated to affect over one billion people in the world, majority of who are in the
developing countries. These diseases include:
Lymphatic Filariasis,
Onchocerciasis,
Schistosomiasis,
Soil Transmitted Helminths (STH),
Human African
Trypanosomaisis,
Guinea Worm Disease,
Trachoma,
Leishmaniasis,
Leprosy,
Buruli Ulcer,
Dengue fever &
Rabies among others.
These NTDs have been confirmed to be endemic in the USAID-supported countries: Benin,
Bangladesh, Burkina Faso, Cambodia, Cameroon, Cote d’Ivoire, Democratic Republic of Congo,
Ethiopia, Ghana, Guinea, Haiti, Indonesia, Mali, Mozambique, Nepal, Niger, Nigeria,
Philippines, Senegal, Sierra Leone, Tanzania, Togo, Uganda, Laos, and Vietnam.
For the purpose of this offer, our works are meant to represent Element two nations (both sub-
element 2A; Bangladesh, Haiti, Indonesia, Laos, Nepal, Philippines & Vietnam and sub-element
2B; DRC, Ethiopia, Mozambique, Nigeria, Tanzania & Uganda).
Our aim is to work hand in hand with USAID and all stakeholders towards achievement of the
USAID NTD eradication goals covering the next five years. In ways of:
-Efficiently and effectively completing the World Health Organization (WHO) treatment
requirements for all communities endemic for Lymphatic Filariasis (LF) and trachoma, and also
in verification and documentation of disease elimination as a public health problem via the WHO
dossier process;
-Working for courses aimed at Maximizing efficiencies and program effectiveness to reach
greater numbers with NTD interventions through leveraging and complementing related sectors
and their platforms, including, Basic Education, Malaria, Water, Sanitation, and Hygiene
(WASH), Maternal and Child Health, and Nutrition. In collaboration with all stakeholders.
Technical Understanding and Proposed Approach:
For the purpose of this offer, our works are meant to represent Element two nations (both sub-
element 2A; Bangladesh, Haiti, Indonesia, Laos, Nepal, Philippines & Vietnam and sub-element
2B; DRC, Ethiopia, Mozambique, Nigeria, Tanzania & Uganda).
Our aim is to work hand in hand with USAID and all stakeholders towards achievement of the
USAID NTDs eradication goals covering the next five years and beyond by collaborating and;
-Efficiently and effectively completing the World Health Organization (WHO) treatment
requirements for all communities endemic for Lymphatic Filariasis (LF) and trachoma, and also
in verification and documentation of disease elimination as a public health problem via the WHO
dossier process;
-Working for courses aimed at Maximizing efficiencies and program effectiveness to reach
greater numbers with NTD interventions through leveraging and complementing related sectors
and their platforms, including, Basic Education, Malaria, Water, Sanitation, and Hygiene
(WASH), Maternal and Child Health, and Nutrition. In collaboration with all stakeholders.
Overview and milestones of the most prevalent NTDs:
Lymphatic filariasis,
Trachoma,
Schistosomiasis,
Onchocerciasis,
And three soil-transmitted helminthes: Ascaris, Trichuris, and Hookworm.
• lymphatic filariasis puts at risk 1.3 billion people in more than 80 countries;
Launched in 2000, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) aims to
eliminate the disease as a public health problem by 2020 by protecting the whole at-risk
population. The number of people exposed to infection is currently 1.3 billion.
Left untreated, this condition leads to the formation of irreversible corneal opacities and
blindness. WHO (2009) estimates that 120 million people in 45 countries are at risk of the
disease and nearly 40 million are infected, compared with 1985 when approximately 360 million
people worldwide were infected. Trachoma is endemic in many of the poorest and most remote
rural areas of Africa, Asia, Central and South America, Australia and the Middle East.
Trachoma in Morocco:
The WHO SAFE strategy for elimination of trachoma involves a combination of interventions:
S – Surgery of the eyelids for those at immediate risk of blindness
A – Antibiotics to treat individual cases and to reduce infection in a community
F – Facial cleanliness and hygiene promotion to reduce transmission
E – Environmental improvements such as provision of water and household sanitation
Through SAFE, Morocco has implemented advocacy and awareness campaigns, particularly
among women and girls, because of their critical role in family and community health.
Schistosomiasis
• Trematodes or flukes are flatworms that live in blood vessels, biliary tract, intestines, and
lungs of humans and lower animals.
• Included are the schistosomes and the foodborne trematodes—liver flukes (Fasciola,
Clonorchis, Opisthorchis), intestinal flukes (various species), and lung fluke (Paragonimus).
EPIDEMIOLOGY
• Schistosomes are prevalent in tropical and subtropical Africa, the Middle East, Southeast
Asia, East Asia, the Philippines, and limited areas in the Caribbean and South America in
areas with inadequate sanitation or access to clean water.
• Foodborne trematodes are most prevalent in Southeast and East Asia but also in other parts
of the world where persons ingest raw or undercooked fish, crayfish, or plants produced in
fresh water contaminated with human or animal feces or (for Paragonimus) sputum.
MICROBIOLOGY
• Persons become infected with schistosomes when the larval parasites (cercariae) shed by
freshwater snails (intermediate hosts) penetrate bare skin.
• Persons become infected with foodborne trematodes by ingesting the larval parasites
(metacercariae) encysted in fish, aquatic vegetation, or crustaceans (second intermediate host)
that were infected with cercariae shed from snails (first intermediate host).
THERAPY
• Praziquantel is the drug of choice
PREVENTION
• For schistosomiasis, preventive methods include sanitation, provision of clean water, snail
control, and avoidance of contact with contaminated fresh water.
• For foodborne trematodes, prevention of infection includes maintaining freshwater bodies
free of contamination by humans and lower animals, snail control, and proper cooking of
aquatic fish, plants, and crustaceans.
• Periodic screening and treatment or mass drug administration for populations at risk for
infection are essential. (James H. Maguire; Infectious Disease ESSENTIALS)
In Nigeria, 846 696 out of 926 913 children of school age received schistosomiasis treatment by
the end of August 2008 in the states of Nasarawa and Plateau. More than 1.5 million donated
praziquantel tablets were shipped to Nigeria in April 2008. In 2007, only 136 000 children had
been treated in the two states. These activities are part of an integrated programme funded by
The Carter Center, working with the Nigerian Ministry of Health in Nasarawa and Plateau.
At the closure of OCP in December 2002, onchocerciasis had been eliminated as a public health
problem and as a disease of socioeconomic importance from 10 out of the 11 countries covered,
although some residual and localized control activities continued in four countries by a restricted
team until December 2007. All 11 countries continue to administer yearly community-directed
treatment with ivermectin and maintain active surveillance of the disease themselves. (Neglected
tropical diseases, hidden successes, emerging opportunities. «WHO/HTM/NTD/2009.2».)
Soil-transmitted helminthiases: group of intestinal helminth infections transmitted through soil
contaminated by human faeces.
Soil-transmitted helminthes:
• Intestinal nematodes or roundworms are helminthic parasites of the human gastrointestinal tract
.
• Ascaris and Trichuris (whipworm) are acquired by ingestion of contaminated soil.
• Strongyloides and hookworms (Ancylostoma, Necator) are acquired by exposure to larvae in
soil.
• Only Enterobius (pinworm) is transmitted from person to person by ingestion of eggs or by
contact with fomites.
EPIDEMIOLOGY
• Soil-transmitted helminths called Strongyloides are prevalent in tropics and subtropics. They
infect more than 1 billion persons, primarily those with limited access to clean water and
sanitation.
• In temperate areas and industrialized countries, Strongyloides are found primarily among
immigrants and travelers returning from the tropics and subtropics.
MICROBIOLOGY
• Ascaris nematodes, hookworms, and Trichuris whipworms cannot replicate in a human host;
hence, there is no person-to-person transmission. The duration of infection is the lifespan of adult
worms, usually less than a few years.
• Strongyloides can replicate in human hosts; hence, infection is acquired via person-to-person
contact and contact with larvae on soil. Infection persists for decades, and numbers of worms can
increase without exogenous reinfection, especially in persons receiving corticosteroids or with
human T-cell lymphotropic virus-1 infection.
• Pinworms are common in all parts of the world, particularly in children.
• Pinworms spread readily by person-to-person contact and ingestion of eggs shed in the
environment, and infected persons frequently reinfect themselves and others in family.
• Hookworms, Ascaris, and Strongyloides migrate through the lung, but whipworms and
pinworms do not.
THERAPY
• Soil-transmitted helminths and pinworms; albendazole, mebendazole, or pyrantel
PREVENTION
• Sanitation, provision of clean water, wearing shoes, hand washing
• Periodic mass drug administration for soil-transmitted helminths
• Strongyloides: suspect, diagnose, and treat before immunosuppressive therapy
Dengue: mosquito-borne viral disease causing flu-like illness. Occasionally develops into a
lethal complication called severe dengue.
Rabies: viral disease transmitted to humans through the bites of infected dogs. Invariably fatal
once symptoms develop.
Buruli ulcer: debilitating skin infection causing severe destruction of the skin, bone and soft
tissue.
Yaws: chronic bacterial infection affecting mainly the skin and bone.
Leprosy: caused by infection mainly of the skin, peripheral nerves, mucosa of the upper
respiratory tract and eyes.
Chagas disease: infection transmitted through contact with vector insects, ingestion of
contaminated food, infected blood transfusion, congenital transmission, organ transplantation or
laboratory accidents.
Leishmaniases: transmitted through the bites of infected female sandflies. In its most severe
(visceral) form, it attacks the internal organs. The most prevalent (cutaneous) form causes face
ulcers, disfiguring scars and disability.
*Onchocerciasis control: annual treatment with Ivermectin to the population at risk and focal
ground larviciding in established isolated vector breeding sites.
*Schistosomiasis control: MDA in the school-aged children and high risk communities, health
education, improvement in water supply and sanitation and Focal control of snail intermediate
hosts in selected foci.
*Trachoma control: Surgery of trichiasis cases, MDA with Azithromycin of entire at risk
identified communities, improved water supply for personal hygiene, personal hygiene
reinforcing face washing, and. environmental management.
*Leprosy elimination: Early case detection, adequate treatment with MDT, provision of
comprehensive patient care (access to free MDT, POD and rehabilitation services), integration of
leprosy services into the general health services, re-organization of existing leprosy services,
community involvement in leprosy control activities, Self Care (including self care groups),
strengthening the referral system and strengthening referral centre.
*Human African Trypanosomiasis Elimination: Surveillance and case reporting, case detection/
management protocols and integration of HAT surveillance and notification into IDSR.
*Buruli Ulcer control: Early and community based case detection, confirmation of cases, case
management (antibiotics, surgery and prevention of disabilities) and strengthening health
structures.
*Guinea worm Eradication: Active surveillance activities in all endemic and recently freed
villages, Community Participatory Surveillance Strategy (CPSS), cash reward scheme, rumour
investigation, documentation / reporting, use of Monofilament filters (Pipe and cloth) to filter
water before consumption and for domestic purposes, provision of safe water supply and
rehabilitation of broken down sources in target and at risk villages, case management /
containment strategy and vector control with.
Progress towards meeting the objectives will be measured against disease specific indicators.
The USAID’s NTD Teams, Federal Governments NTDs secretariat, zonal NTDs offices and the
NTDs Steering Committee will provide oversight for effective programme implementation. All
these mechanisms properly put in place should help towards actualization of the eradication and
control goals in the long run. We are totally committed to Gender equality procedures as
mandated by the USAID Gender Equality and Female Empowerment Policy as at when
circumstances allows.
Priorities;
Towards achieving USAID’s goals for NTD elimination and control, we will employ our
educational facility (African College of Health) in spreading out educative points as regards
NTDs to the communities involved putting gender gaps (on whatever ground) on top of our
priority list.
Challenges;
Upsurge in terror activities and funding problems. Our online education facility is a purposely
organized institution for the displaced and has contributed to WHO’s disease elimination
straregies for control and elimination of NTDs for years. We are looking forward to partnering
with stakeholders, thereby maximizing opportunities and addressing key challenges that debar
operations as integrated into the NTD programs.
We will be involved in exhibiting technical expertise, risk management acumen, and data
handling methods as required and according to the rules set by the host Nation (s) towards :
We are currently working ( we currently offer 2 weeks free road show per year on each) on the
following programs towards attainment of NTDs elimination status for the entire world via our
online education platform @ https://www.facebook.com/groups/africancollegeofht/ :
Other Personnel: To be recruited upon NOA. We are short of financial means to accrue
specialists.
BUDGET NARRATIVE
Anticipated Project budget items; totaling $21 million USD for a period of 5 years: