Scribd Logo
Upload

Welcome to Scribd!

  • AA Ionisation Summary

    Uploaded by

    Jen
    8 views1 page
    This document outlines the functional groups found in amino acids, their pKa values, and whether the dominant structure and charge is positive, negative, or neutral when the pH is below or above the pKa. It shows that the backbone amino and carboxylic acid groups have a pKa near 9.5 and 2 respectively, and the side chains of aspartic acid, glutamic acid, cysteine, lysine, arginine, and histidine contain additional carboxylic acid, thiol, amino, guanidinium, or imidazole groups with pKas between 4 and 12.5.

    Original Description:

    Amino Acid Ionisation Summary

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document outlines the functional groups found in amino acids, their pKa values, and whether the dominant structure and charge is positive, negative, or neutral when the pH is below or above the pKa. It shows that the backbone amino and carboxylic acid groups have a pKa near 9.5 and 2 respectively, and the side chains of aspartic acid, glutamic acid, cysteine, lysine, arginine, and histidine contain additional carboxylic acid, thiol, amino, guanidinium, or imidazole groups with pKas between 4 and 12.5.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views1 page

    AA Ionisation Summary

    Uploaded by

    Jen
    This document outlines the functional groups found in amino acids, their pKa values, and whether the dominant structure and charge is positive, negative, or neutral when the pH is below or above the pKa. It shows that the backbone amino and carboxylic acid groups have a pKa near 9.5 and 2 respectively, and the side chains of aspartic acid, glutamic acid, cysteine, lysine, arginine, and histidine contain additional carboxylic acid, thiol, amino, guanidinium, or imidazole groups with pKas between 4 and 12.5.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Ionisation of Functional Groups in Amino Acids

    Amino Acid Functional pKa Dominant structure and Dominant structure and
    Group* (approx.) charge when pH < pKa charge when pH > pKa
    All BB amino 9.5

    Positive Neutral
    All BB carboxylic acid 2.0

    Neutral Negative
    Asp and Glu SC carboxylic acid 4.0

    Neutral Negative
    Cys SC thiol 8.0

    Neutral Negative
    Lys SC amino 10.5

    Positive Neutral
    Arg SC guanidinium 12.5

    Positive Neutral
    His SC imidazole 6.0

    Positive Neutral
    *BB = backbone group; SC = side chain group

    You might also like