GASTROINTESTINAL STROMAL TUMOR (GIST)

ABSTRAK

Madin, Dionisia Irpatima. 2016. Gastrointestinal Stromal Tumor. Jayapura : Medical Degree
Program. Scholarly Scientific Writing, Medical Faculty of Cenderawasih University. Advisors :
(1) dr. Trajanus L. Jembise, Sp.B (2) Lusye Howay, S.Psi

Gastrointestinal stromal tumor (GIST) is a type of mesenchymal tumor. This tumor is most
common in the gastrointestinal tract. Mesenchymal tumors are derived from myenteric ganglion
cells (Interstitial Cell of Cajal / ICC) that act as pacemaker cells. These cells act as regulators of
intestinal motility. The GIST epidemiology is not known for certain because GIST is a rare type
of tumor. The latest estimate in the UK, GIST incidence ranges from 1.32-1.50 per 100,000
population or the equivalent of 800-900 new cases each year. The main cause of GIST is not
known for certain. However, there are several factors that cause the occurrence of GIST. These
factors include: patients with type I neurofibromatosis, people with a family history of
gastrointestinal tumors, and in Carney's triad tumor syndrome. GIST is usually more common in
men than in women. The average GIST sufferer is over 40 years old. GIST can be treated with
surgery. However, this action can not completely cure GIST. Other treatment options often used
in GIST are imatinib mesylate, sunitinib malate and regorafenib. The prognosis of GIST
depends on the size or size of the tumor and the rupture.

Key Terms : Gastrointestinal Stromal Tumor