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[First author] et al

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Author name Arief Purwodito,

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Author affiliations Departement of Neurosurgery, Faculty of Medicine DR. Cipto Mangunkusumo National

Hospital, Jakarta, Indonesia; 2Author affiliations

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Abstract

Background: butterfly glioblastoma defined as the initial presentation of a grade IV 
astrocytoma with contiguous enhancement in bilateral cerebral hemispheres most 
commonly spread via eloquent area such us corpus callosum. Because anatomical 
involvement and the location as the limiting factor, surgical treatment is more challenging.
Methods: Sample were taken by consecutive sampling method, in which all patients with complete medical

record diagnosed by Glioblastoma and astrocytoma (WHO Grade I-IV) in Neurosurgery Departement of DR.

Cipto Mangunkusumo National Center Hospital from 2015 - 2018 to complete this descriptive study.

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Results: Glioblastoma is the most common glial cell tumors (70,4%).

Conclusion:

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Fundings: State in a table for the funding sources (if there is any)

Introduction

Glioblastoma multiforme is an extremely aggressive diffuse astrocytic tumor commonly found in the

supratentorial white matter of the cerebral hemispheres. It is the most common primary brain tumor in adults,

accounting for 25% of all cases. Glioblastomas most commonly spread via direct extension along white

matter tracts, including the corpus callosum, although hematogenous, subependymal, and cerebrospinal

fluid spread can also be seen. On MR imaging, these tumors typically enhance solidly and intensely in the

corpus callosum, although occasionally no enhancement is seen. Because the corpus callosum is relatively

resistant to infiltration, glioblastoma multiforme should be considered for any lesion crossing the corpus

callosum.1 Bourekas EC, Varakis K, Bruns D, Christoforidis GA, Baujan M, Slone HW, Kehagias D. Lesions of the

corpus callosum: MR imaging and differential considerations in adults and children. American Journal of

Roentgenology. 2002 Jul;179(1):251-7.

Theris no sufficient data about butterfly glioma study, but Dziurzynski K et. al reported 792 patients with a new

diagnosis of glioblastoma, twenty-three patients (2.9 %) were identified that met researcher criteria of butterfly

glioblastoma.2 Dziurzynski K, Blas-Boria D, Suki D, Cahill DP, Prabhu SS, Puduvalli V, Levine N. Butterfly

glioblastomas: a retrospective review and qualitative assessment of outcomes. Journal of neuro-oncology. 2012 Sep

1;109(3):555-63

The other study about surgical resection reported Twenty­nine (3.8%) of 764 newly diagnosed GBMs 

were identified as butterfly glioblastoma, only 9 patients (31.0%) underwent surgical 
resection.3 Opoku-Darko M, Amuah JE, Kelly JJ. Surgical resection of anterior and posterior butterfly
glioblastoma. World neurosurgery. 2018 Feb 1;110:e612-20.

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[Generally each major section of your manuscript should have a heading. The most common breakdown of a

paper is given below, with some subheadings related to the above example text. Please delete or include as

needed.]

Material and methods

Sample were taken by consecutive sampling method, in which all patients with complete medical record

diagnosed by Glioblastoma and astrocytoma (WHO Grade I-IV) in Neurosurgery Departement of DR. Cipto

Mangunkusumo National Center Hospital from 2015 - 2018 to complete this descriptive study.

Data were extracted secondarily from medical records. Variables in this study were: sex, age group,

symptoms, duration of symptoms, histopathology report, and the surgical procedure. Radiologic

characteristic we tested including location, lobus involvement, corpus callosum extension (genu, corpus, and

splenium), compression of lateral ventricle, and butterfly appearance. The radiologic characteristic was

evaluated by 3 neurosurgeon with neuro-oncology background, whenever there is discrepacy of expertise

any of them, the decision was made by further discussion and agreement. All data were analyzed and

presented in the frequency table.

Results

There were 27 samples of total Glioblastoma and Astrocytoma (WHO Grade I - IV) in this study. 19 sample

(70,4 %) was confirmed Glioblastoma Figure 1. (WHO Grade IV). Subjects characteristic and radiologic

findings was presented in table.

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Discussion

Conclusion

Acknowledgments

Disclosure

The author reports no conflicts of interest in this work. [Each manuscript needs to include a disclosure of

financial interest or other conflict of interest statement. This is where these statements go].

References

[The following are examples of our reference style.]

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3. Fried LF, Palevsky PM. Hyponatremia and hypernatremia. Med Clin North Am. 1997;81:585–609.

4. Gheorghiade M, Konstam MA, Burnett JC Jr, et al; Efficacy of Vasopressin Antagonism in Heart

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 Clinical Status Trials. JAMA. 2007;297:1332–1343.

5. Vaprisol (conivaptan HCl injection) [package insert]. Deerfield IL: Astellas Tokai Co.; February 2006.

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Table 1 [Table titles are in sentence case and do not end with a full-stop.]

Notes:

Abbreviations: AUC, area under the curve; LS, least squares; NE, not estimable. [These are examples of

format.]

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Figure 1 [Title of figure is in sentence case and ends in a full stop.]

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