Biochemical and Biophysical Research Communications 318 (2004) 801

BBRC
www.elsevier.com/locate/ybbrc

Corrigendum

Corrigendum “A missense mutant myostatin causes hyperplasia

without hypertrophy in the mouse muscle” [Biochem. Biophys.
Res. Commun. 293 (2002) 247–251]q
Masumi Nishi,a,b Akihiro Yasue,a,b Shinichirou Nishimatu,c Tsutomu Nohno,c
Takashi Yamaoka,d Mitsuo Itakura,d Keiji Moriyama,b Hideyo Ohuchi,a
and Sumihare Nojia,*
a
Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, 2-1 Minami-Jyosanjima cho,
Tokushima 770-8506, Japan
b
Department of Orthodontics, Faculty of Dentistry, University of Tokushima, 3-18-10 Kuramoto-cho, Tokushima 770-8504, Japan
c
Department of Molecular Biology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0114, Japan
d
Division of Genetic Information, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan

So far, a few types of mutations in myostatin in
double-muscled cattle have been reported. Piedmontese
cattle have a C313Y mutation, whereas Belgian Blue
cattle have an 11-nucleotide deletion that causes a
frameshift mutation. This frameshift mutation produces
a premature stop codon at amino acid position 288 [1].
We generated transgenic mice overexpressing these
mutant myostatins to examine whether these mutations
in the myostatin gene affect muscle development in a
dominant negative manner.
In our paper, we described the generation of trans-
genic mice overexpressing a C313Y myostatin mutant
found in Piedmontese, but we recently realized that the
transgenic mice that we analyzed were not the mice
overexpressing “a missense (C313Y) mutation found in
Piedmontese,” but “a deletion mutation found in Bel-
gian Blue.” Therefore, the title, “A missense mutant
myostatin causes hyperplasia without hypertrophy in
the mouse muscle,” should read “A deletion mutant
myostatin causes hyperplasia without hypertrophy in
the mouse muscle.”
In the Results, we wrote that a transgene with the
predicted size of “1.3 kb” was confirmed by PCR anal-
ysis, but its size is “1 kb” in the case of the deletion
mutant.
Moreover, the descriptions in Fig. 1B and C are re-
versed. Transgenic mice having a C313Y missense mu-
tation in myostatin also exhibit increase in the skeletal
muscle mass. We regret any confusion caused by these
errors.
Reference
[1] R. Kambadur, M. Sharma, T.P. Smith, J.J. Bass, Mutations in
myostatin (GDF8) in double-muscled Belgian Blue and Piedmon-
tese cattle, Genome Res. 7 (1997) 910–916.

q
DOI of original article: 10.1016/S0006-291X(02)00209-7.
*
Corresponding author. Fax: +81-88-656-9074.
E-mail address: noji@bio.tokushima-u.ac.jp (S. Noji).

0006-291X/$ - see front matter Ó 2004 Published by Elsevier Inc.

doi:10.1016/j.bbrc.2004.04.091

View publication stats