NANDROLONE DECANOATE

Deca-Durabolin is a brand name of Nandrolone decanoate. It is a very slow acting and an

extremely popular anabolic steroid similar to testosterone. However, it lacks the carbon atom
at the 19th position and by this fact is officially known as 19 nor testosterone compound like
testosterone.

Deca-Durabolin anabolic steroid is highly anabolic but its androgenic nature is much weaker.
This weaker nature has made it a very popular steroid among many performance athletes and it
holds numerous favorable qualities in therapeutic treatment.

Deca-Durabolin anabolic steroid represents a nandrolone hormone attached to the massive

decanoate ester. This massive ester greatly slows down its release time. Deca-Durabolin has
long been considered one of the greatest steroids to hit the market for therapeutic purposes. It
has been shown to have a tremendously positive effect on combating osteoporosis, advanced
breast cancer, ulcers and anemia. It has also been shown to be extremely effective for those
suffering from HIV and burn victims as well as being a fantastic steroid for promoting weight
gain. It is also favorable among many performance-enhancing athletes and it is a bulking steroid
due to its ability to promote slow yet significant tissue growth.

Deca-Durabolin anabolic steroid is a clear yellow oily solution for injection containing a
different concentration of the active ingredient Nandrolone decanoate. It helps to rebuild
tissue that might become weak because of continuing illness or serious injury. Deca-Durabolin
can be used to increase lean body mass in the case of negative nitrogen balance. It can also be
used to increase bone mass and stimulate the formation of red blood cells in the bone marrow.

Indications and usage:

Nandrolone Decanoate is indicated for the management of the anaemia of renal Insufficiency
and has been shown to increase haemoglobin and red cell mass.

Mechanism of Action:

Nandrolone Decanoate has action similar to endogenous androgens such as testosterone.

Exogenous androgens such as nandrolone decanoate promote protein anabolism and stimulate
appetite which results in a reversal of catabolic processes and negative nitrogen balance.
Increases in lean body mass in patients with cachexia (e.g., malnourished dialysis patients) and
decreased bone resorption and increased bone density in patients with osteoporosis. Blood
glucose, erythrocyte production, and the balance of calcium are also affected by androgens.

Patients with anemia associated with renal disease will have increases in red blood cell volume
and hemoglobin after receiving nandrolone decanoate.

Administration of nandrolone decanoate has the possibility of causing serious disturbances of

growth and sexual development if given to young children and causing unwanted adverse
effects in women. Exogenous androgens suppress gonadotropin-releasing hormone, thereby
reducing the gonadotropic function of the pituitary through a negative-feedback mechanism.
This results in a reduction of endogenous testosterone, luteinizing hormone, and follicle-
stimulating hormone. Exogenous androgens may also have a direct effect on the testes.

Reversible increases in low-density lipoproteins (LDL) and decreases in high-density lipoproteins

(HDL) also occur.

Contraindications:

Male patients with carcinoma of the breast or with suspected carcinoma of the prostate.

Carcinoma of the breast in females with hypercalcemia: androgenic anabolic steroids may
stimulate osteolytic resorption of bones.

Pregnancy, because of masculinization of the foetus.

Nephrosis or the nephritic phase of nephritis.

Patients with serious cardiac, hepatic or renal disease.

Androgen therapy (such as nandrolone) can result in loss of diabetic control and should be used
with caution in patients with diabetes mellitus.

Adverse Reactions:

Hepatic:
Hepatocellular neoplasms and peliosis hepatitis have been reported in association with long-
term androgenic anabolic steroid therapy).
Genitourinary System:
In men.
a. Prepubertal: Phallic enlargement and increased frequency of erections.
b. Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia,
impotence, chronic priapism, epididymitis and bladder irritability.
In women: Clitoral enlargement, menstrual irregularities. In both sexes: Increased or decreased
libido.

CNS:
Habituation, excitation, insomnia, depression.
Gastrointestinal:
Nausea, vomiting, diarrhea.
Hematologic:
Bleeding in patients on concomitant anticoagulant therapy
Breast:
Gynecomastia.
Larynx:
Deepening of the voice in women.
Hair:
Hirsutism and male pattern of baldness in women.
Skin:
Acne (especially in women and prepubertal boys.)
Skeletal:
Premature closure of epiphyses in children
Fluid and Electrolytes:
Edema, retention of serum electrolytes (sodium, chloride, potassium, phosphate, calcium.
Metabolic/Endocrine:
Decreased glucose tolerance increased serum levels of low-density lipoprotein and decreased
levels of high-density lipoprotein, increased creatine and creatinine excretion, increased serum
levels of creatinine phosphokinase (CPK). Some virilizing changes in women are irreversible
even after prompt discontinuance of therapy and are not prevented by concomitant use of
estrogens.

Overdosage:

There have been no reports of acute overdosage with the anabolics.

Precautions:

Nandrolone Decanoate should be used with caution in patients with any disease, especially
cancer of the prostate or breast, liver, heart.

Kidney disease, allergy, enlarged prostate. High dosage, long term use of androgens has been
related to liver cancer.

This drug should not be used during pregnancy or lactation. Females should be monitored for
signs virilization, such as deepening of the voice.

Facial haft, acne, menstrual irregularity or clitoral enlargement, consult the doctor promptly if
any of these symptoms occur.
Use in children should not be recommended due to the possibility this drug may have
undesirable effects related to the growth of the child.

It should be used with extreme caution in geriatric men because they are at higher risk for
developing enlarged prostates or prostate cancer when using this medication.

Dosage and administration:

Nandrolone Decanoate is intended only for deep intramuscular injection preferably into the
gluteal muscle (such as the buttock, upper leg or upper arm). Dosage should be based on the
therapeutic response and severity of the patient’s condition.

For women: 50-100 mg per week

For men: 100-250 mg per week

For children from 2 to 13 years of age, 25-50 mg every 3 to 4 weeks.

Anaemia of renal disease:

Drug therapy should be discontinued if no hematologic improvement is seen within the first six
months. When used in the treatment of renal insufficiency, adequate iron intake is required for
maximal response.

Warnings:

Peliosis hepatitis, a condition in which liver and sometimes splenic tissue is replaced with blood-
filled cysts, occurred in patients receiving androgenic anabolic steroids. The condition may not
be recognized until life threatening liver failure or intra-abdominal haemorrhage develops. Drug
discontinuation often results in regression or cessation of tumour growth.

Blood lipid changes including decreased HDL and increased LDL leads to increased risk of
atherosclerosis are seen of some patients treated with androgens and anabolic steroids

This product should be used under proper medical supervision.

Storage Condition:

Nandrolone Decanoate should be stored at controlled room temperatures below 30°C and
protected from light.