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DISEASE PROGRAM
Description
In the recent past, the Philippines has seen many outbreaks of emerging
infectious diseases and it continues to be susceptible to the threat of re-
emerging infections such as leptospirosis, dengue, meningococcemia,
tuberculosis among. The current situation emphasizes the risks and
highlights the need to improve preparedness at local, national and
international levels for against future pandemics. New pathogens will
continue to emerge and spread across regions and will challenge public
health as never before signifying grim repercussions and health burden.
These may cause countless morbidities and mortalities, disrupting trade and
negatively affect the economy.
Vision
Mission
Provide and strengthen an integrated, responsive, and collaborative health
system on emerging and re-emerging infectious diseases towards a healthy
and bio-secure country.
Goal
Program Strategies
Policy Development
Resource Management and Mobilization
Coordinated Networks of Facilities
Building Health Human Resource Capacity
Establishment of Logistics Management System
Managing Information to Enhance Disease Surveillance
Improving Risk Communication and Advocacy
Area of Coverage
Partner Institutions
To achieve this goal within the medium term, with a benchmark of less than
one percent EREID case fatality rate, the EREID Program Strategic
Investment Plan highlights the seven Strategic Priorities, each with the
following goals:
Calendar of Activities
Statistics
https://www.doh.gov.ph/emerging-and-re-emerging-infectious-disease-program
Infectious Diseases
1. Acute Respiratory Infection
2. Influenza A (H1N1)
3. Bird Flu (Avian Influenza)
4. Chickenpox
5. Cholera
6. Dengue
7. Diarrhea
8. Diphtheria
9. Ebola
10.Hand, Foot, and Mouth Disease
11.Hepatitis A
12.Hepatitis B
13.Hepatitis C
14.HIV/AIDS
15.Influenza
16.Leprosy
17. Malaria
18.Measles
19.Meningococcemia
20. Pertussis
21. Poliomyelitis
22. Rabies
23. Severe Acute Respiratory Syndrome (SARS)
24. Sore Eyes
25. Tuberculosis
26. Typhoid Fever
http://caro.doh.gov.ph/?page_id=383
DENGUE
BACKGROUND
Dengue is the fastest spreading vector-borne disease in the world endemic in 100 countries·
Dengue virus has four serotypes (DENV1, DENV2, DENV3 and DENV4)
First infection with one of the four serotypes usually is non-severe or asymptomatic, while
second infection with one of other serotypes may cause severe dengue.
The five year average cases of dengue is 185,008; five year average deaths is 732; and five
year average Case Fatality Rate is 0.39 (2012-2016 data).
TRANSMISSION
Dengue virus is transmitted by day biting Aedes aegypti and Aedes albopictus mosquitoes.
Dengue without warning warnings can be further classified according to signs and symptoms
and laboratory tests as suspect dengue, probable dengue and confirmed dengue.
- a previously well individual with acute febrile illness of 1-7 days duration
plus two of the following: headache, body malaise, retro-orbital pain, myalgia,
arthralgia, anorexia, nausea, vomiting, diarrhea, flushed skin, rash (petechial,
Hermann’s sign)
- a suspect dengue case plus laboratory test: Dengue NS1 antigen test and atleast
CBC (leukopenia with or without thrombocytopenia) or dengue IgM antibody test
(optional)
• a previously well person with acute febrile illness of 1-7 days plus any of the following:
abdominial pain or tenderness, persistent vomiting, clinical signs of fluid accumulation
(ascites), mucosal bleeding, lethargy or restlessness, liver enlargement, increase in
haematocrit and/or decreasing platelet count
c. severe dengue
shock (DSS)
severe bleeding
as evaluated by clinician
a. Febrile Phase
Usually last 2-7 days
Mild haemorrhagic manifestations like petechiae and mucosal membrane bleeding (e.g
nose and gums) may be seen.
Monitoring of warning signs is crucial to recognize its progression to critical phase.
b. Critical Phase
Phase when patient can either improve or deteriorate.
Defervescence occurs between 3 to 7 days of illness. Defervescence is
known as the period in which the body temperature (fever) drops to almost
normal (between 37.5 to 38°C).
Those who will improve after defervescence will be categorized as Dengue
without Warning Signs, while those who will deteriorate will manifest warning
signs and will be categorized as Dengue with Warning Signs or some may
progress to Severe Dengue.
When warning signs occurs, severe dengue may follow near the time of
defervescence which usually happens between 24 to 48 hours.
c. Recovery Phase
Happens in the next 48 to 72 hours in which the body fluids go
back to normal.
Patients’ general well-being improves.
Some patients may have classical rash of “isles of white in the sea of
red”.
The White Blood Cell (WBC) usually starts to rise soon after
defervescence but the normalization of platelet counts typically
happens later than that of WBC.
Patients shall be referred immediately to in-hospital management if they have the following
conditions:
Warning signs\
Without warning signs but with co-existing conditions that may make dengue
or its management more complicated ( such as pregnancy, infancy, old age,
obesity, diabetes mellitus, hypertension, heart failure, renal failure, chronic
haemolytic diseases such as sickle- cell disease and autoimmune diseases,
etc.)
Social circumstances such as living alone or living far from health facility or
without a reliable means of transportation.
The referring facility has no capability to manage dengue with warning signs
and/or severe dengue.
3. Group C- patient with severe dengue.requiring emergency treatment and
urgent referral
These are patients with severe dengue who require emergency treatment
and urgent referral because they are in the critical phase of the disease and
have the following:
Patients in Group C shall be immediately referred and admitted in the hospital within 24
hours.
LABORATORY TESTS
Test Description
Requested between 1-5 days of illness
Use to detect dengue virus antigen during
early phase of acute dengue infection
1. Dengue NS1 RDT
Test is for free in all health centers and
selected public hospitals nationwide
Requested beyond five days of illness
Use to detect dengue antibodies during
acute late stage of dengue infection (IgM)
and to determine previous infection (IgG)
May give false positive result due to
2. Dengue IgM/IgG antibodies induced by dengue vaccine
May cross react with other arboviral diseases
such as Chikungunya and Zika
DOH augmentation is limited to selected
government hospitals only
One of the gold standard laboratory tests to
confirm dengue virus.
Molecular based test confirmatory test
3. Polymerase Chain Reaction (PCR)
Available only in dengue sub-national and
national reference laboratories
A novel molecular-based confirmatory test
used to detect dengue virus.
Work just like PCR but cheaper and simpler
4. Nucleic Acid Amplification Test- in nature.
Loop Mediated Isothermal Amplification
Assay (NAAT-LAMP) In the pipeline to be introduced under the
National Dengue Prevention and Control
Program in district and provincial hospitals
Gold standard to characterize and quantify
circulating level of anti-DENV neutralizing
5. Plaque Reduction Neutralization antibody (NAb)
Test (PRNT) Available only at the dengue national
reference laboratory
6. Other tests:
Routinely used in hospitals as standard
-Total While Blood Cell (WBC) count dengue diagnostic tests
Look for trend of decreasing WBC,
-Platelet decreasing platelet and increasing
hematocrit
-Hematocrit
Mission Ensure healthy lives and promote well-being for all at all
ages
total population
total population
PROGRAM COMPONENTS
1. Surveillance
Case Surveillance through Philippine Integrated Disease
Surveillance and Response (PIDSR)
Laboratory-based surveillance/ virus surveillance through
Research Institute for Tropical Medicine (RITM) Department of
Virology, as national reference laboratory, and sub-national
reference laboratories.
Vector Surveillance through DOH Regional Offices and RITM
Department of Entomology
4. Outbreak Response
6. Research
STRATEGIES
Enhanced 4S Strategy
AO 2016-0043
Guidelines for the nationwide Implementation of Dengue Rapid Diagnostic Test
AO 2012-006
Revised Dengue Clinical Management Guidelines
AO 2001-0045 Guidelines on the Application of Larvicides on the Breeding Sites of Dengue Vector Mosquitoes in Domestic W
DM 2017-0353 Implementation Guidelines for Initial Implementation of Nucleic Acid Amplification Assay - Loop Mediated Iso
(LAMP) as One of Dengue Confirmatory Tests to Support Dengue NSI RDT
DM 2015-0309 Reactivation of Dengue Fast Lanes and Continuing Improvement of Systems for Dengue Case Management an
Technical Guidelines, Standards and other Instructions for Reference in the Implementation of Sentinel-based
DM 2014-0112
Surveillance
https://www.doh.gov.ph/Health-Advisory/Dengue
Evalyn A. Roxas, MD
Assistant Professor
Dr. Evalyn A. Roxas is a graduate of Bachelor of Science in Biology, magna cum laude from
the Pamantasan ng Lungsod ng Maynila (PLM). She then pursued studying in the same
university and graduated with the degree of Doctor of Medicine finishing rank 6 of her class.
After this, she continued her medical profession and had residency training in Internal
Medicine from Ospital ng Maynila Medical Center. She further subspecialize in Infectious
Diseases and completed her fellowship training in the said program from the University of
the Philippines-Philippine General Hospital (UP-PGH). She is now a diplomate and fellow
both of the Philippine College of Physicians (PCP) and Philippine Society for Microbiology and
Infectious Diseases (PSMID).
Her interest in microbiology and infectious diseases brought her at the Department of
Medical Microbiology. She is now the newest addition to the distinguished roster of faculty of
the Department with a rank of Assistant Professor V. She teaches BS Public Health
undergraduate students and also dentistry, nursing and medical students.
Some of her interests even when she was still a fellow were on leptospirosis and HIV where
she was able to publish papers entitled “Clinical Profile of Patients Diagnosed with
Leptospirosis After a Typhoon” and “A Case Report on Invasive Trichosponosis in an AIDS
Patient”. She had short course training also on leptospirosis at the Department of
Bacteriology of Kyushu University in Fukuoka, Japan.
Currently her research interests are still on leptospirosis , HIV, TB, and infection control.
She continuously hones and improves her potential as an academician as she is presently
enrolled at the graduate school of the College of Public Health taking up Master of Public
Health.
Contact:
5260811
Publications
Lopez SM, Ramiro VR, and Roxas EA. Measuring Stigma and Discrimination
towards People Living with HIV among Health Care Workers in a Tertiary, Government
Teaching Hospital in the Philippines. Acta Medica Philippina. (2017); 51 (4); 319-326
Salvana EMT, Roxas EA, Penamora MG. Immunocompromised Hosts and Parasitic
Infections. Chapter 8: Special Topics in Parasitology.In Vicente Y. Belizario Jr. and
Winifreda U de Leon (eds). Medical Parasitology in the Philippines.. University of the
Philippines Press 2015. (Chapter in a Book). (2015); ;
Gloriani NG, Cavinta LC, Roxas EA, Villanueva SYAM. Prevention and Control of
Leptospirosis in the Philippines: A Manual for Health Workers.. DOST-PCHRD. (2015); ;
Mendoza M, Roxas E, et al.. Clinical Profile of Patients Diagnosed with
Leptospirosis After a Typhoon: A Multicenter Study.. Southeast Asian J Trop Med Public
Health . (2013). (2013); 44 (6); 1021-1035
Mendoza M, Roxas E, et al. Clinical Profile of Patients Diagnosed with Leptospirosis
After a Typhoon: A Multicenter Study. Southeast Asian J Trop Med Public Health .
(2013); 44 (6); 1021-1035
Roman D, Salvana E, Penamora M, Roxas E, Leyritana K, and Saniel M..
Invasive Trichosporonosis in an AIDS Patient: Case Report and Review of the Literature..
International Journal Of STD and AIDS. July 2013.. ; ;
Roman D, Salvana E, Penamora M, Roxas E, Leyritana K, and Saniel M..
Trichosponosis in an AIDS Patient: Case Report and Review of the Literature.
International Journal of STD and AIDS. ; ;
http://cph.upm.edu.ph/user-profile/117
WHO/Chris Black
http://www.who.int/topics/infectious_diseases/en/
Raquel Victoria M.
Ecarma, M.D.
Section Head Chair,
Infection Control
Committee
University of the East Ramon Magsaysay
Medical School:
Memorial Medical Center (UERMMMC)
National Kidney and Transplant Institute
Residency:
Department of Internal Medicine
UP- Philippine General Hospital(Infectious
Fellowship:
Diseases)
Infectious Disease,Internal Medicine
Specialization: Transplant InfectionsHIV/AIDS Infection
Control
We have been honored with the Philhealth award of excellence and the
gold awardee for malinis, mabango na ospital by the Department of
Health.
http://rmc.doh.gov.ph/training