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Inhibitory Activity On Advanced Glycation End Products (Ages
Inhibitory Activity On Advanced Glycation End Products (Ages
The compound of the seeds of Leucaena leucocephala (Lmk) De Wit that could inhibit on
Advanced Glycation End Products (AGEs) Formation are potentially used for antidiabetic
by suppressing postprandial hyperglycaemia. This research aimed to investigate the
hypoglycaemic activity in compounds of the seeds of Leucaena leucocephala (lmk) De Wit
using an in vitro bioassay based on the inhibition of the formation of AGEs. The active
constituent showed potential as inhibit on AGEs with IC50 28,32 mg/mL. In animal
experiment of active constituent suppressed the increase of postprandial blood glucose
level compare to the control (p<0,05). The structure of active constituent galactomannan
was determined by spectroscopic data interpretation and by comparison of these data with
vqlues in the literature.
Key words : Leucaena leucocephala (Lmk), Advanced Glycation End Product, active
constituent, postprandial hyperglycaemia
ACKNOWLEDGMENTS
We would like thank to Dr. M. Hanafi, The
Research Centre for Chemistry, Indonesian Institute
of Science, Serpong for running 1H & 13C-NMR
measurements.