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Why sodium hydroxide is used for DNA digestion to do genotyping?

In DNA isolation or extraction, NaOH ( Sodium hydroxide) is used as alkaline lysis buffer. It basically helps in
dissolving the cell membrane so that the inner components of the cell including the DNA come out. The
dissolution process happens when NaOH along with SDS (Sodium Dodecyl Sulphate) breaks the hydrogen
bonding (H bonds) between the two strands of the double stranded DNA helix and denatures them into a
single strand. This method is called the Alkaline Lysis method.

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