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MYC & BCL2 or BCL6 co-expression in DLBCL Zawam et al.

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Accordingly, appropriate first-line treatment could be Perry AM, Alvarado-Berna lY, Laurini JA, Smith LM, Slack GW, Tan KL, et al.
modified to overcome the dismal response of these cases (2014). MYC and BCL2 protein expression predicts survival in patients with
diffuse large B-cell lymphoma treated with rituximab. Br J Haematol
to the standard R-CHOP regimen. 165:382–391.
Petrich AM, Gandhi M, Jovanovic B, Castillo JJ, Rajguru S, Yang DT, et al. (2014).
Conflicts of interest Impact of induction regimen and stem cell transplantation on outcomes in
patients with double hit lymphoma: a large multicenter retrospective analysis.
There are no conflicts of interest. Blood 124:2354–2361.
Pfreundschuh M, Truemper L, Gill D, Osterborg A, Pettengell R, Trneny M, et al.
(2004). First analysis of the completed Mabthera International (Mint) Trial in
References young patients with low-risk diffuse large B-cell lymphoma (DLBCL): addition
Abdelhamid T, Samra M, Ramadan H, Mehessin M, Mokhtar N (2011). Clinical of rituximab to a CHOP-like regimen significantly improves outcome of all
prognostic factors of diffuse large B cell non-Hodgkin lymphoma: patients with the identification of a very favorable subgroup with IPI = O and
a retrospective study. J Egypt Natl Canc Inst 23:17–24. no bulky disease. Blood 104:48a.
Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E, et al. Sehn LH, Donaldson J, Chhanabhai M, Fitzgerald C, Gill K, Klasa R, et al. (2005).
(2010). Concordance between four European centres of PET reporting Introduction of combined CHOP plus rituximab therapy dramatically improved
criteria designed for use in multicentre trials in Hodgkin lymphoma. Eur J Nucl outcome of diffuse large B-cell lymphoma in British Columbia. J Clin Oncol
Med Mol Imaging 37:1824–1833. 23:5027–5033.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Sehn LH, Berry B, Chhanabhai M, Fitzgerald C, Gill K, Hoskins P, et al. (2007).
(2014). Recommendations for initial evaluation, staging, and response The revised International Prognostic Index (R-IPI) is a better predictor of
assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classifica- outcome than the standard IPI for patients with diffuse large B-cell lymphoma
tion. J Clin Oncol 32:3059–3068. treated with R-CHOP. Blood 109:1857–1861.
Green T, Young K, Visco C, Xu-Monette ZY, Orazi A, Go RS, et al. (2012). Shenoy PJ, Malik N, Nooka A, Sinha R, Ward KC, Brawley OW, et al. (2010).
Immunohistochemical double hit score is a strong predictor of outcome in patients Racial differences in the presentation and outcomes of diffuse large B-cell
with diffuse large B cell lymphoma treated with rituximab plus cyclophosphamide, lymphoma in the United States. Cancer 117:2530–2540.
doxorubicin, vincristine and, predinisone. J Clin Oncol 30:3460–3467. Smith SM (2017a). Aggressive B-cell lymphoma: the double-hit and double-
Herrera AF, Mei M, Low L, Kim HT, Griffin GK, Song JY, et al. (2016). Relapsed or expressor phenotypes. Clin Adv Hematol Oncol 15:40–42.
refractory double-expressor and double-hit lymphomas have inferior progression- Smith SM (2017b). Impact of double-hit and double-expressor phenotypes in
free survival after autologous stem-cell transplantation. J Clin Oncol 68:2740. relapsed aggressive B-cell lymphomas treated with autologous hematopoietic
Horn H, Ziepert M, Becher C, Barth TF, Bernd HW, Feller AC, et al. (2013). MYC stem cell transplantation. J Clin Oncol 35:1–3.
status in concert with BCL2 and BCL6 expression predicts outcome in Swerdlow S (2014). Diagnosis of ‘double hit’ diffuse large B-cell lymphoma and
diffuse large B-cell lymphoma. Blood 121:2253–2263. B-cell lymphoma, unclassifiable, with features intermediate between DLBCL
Hu S, Xu-Monette Z, Tzankov A, Green T, Wu L, Balasubramanyam A, et al. and Burkitt lymphoma: when and how, FISH versus IHC. Hematology Am Soc
(2013). MYC/BCL2 protein coexpression contributes to the inferior survival of Hematol Educ Program 1:90–99.
activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. (2016).
high-risk gene expression signatures: a report from The International DLBCL The 2016 revision of the World Health Organization classification of lymphoid
Rituximab-CHOP Consortium Program. Blood 121:4021–4031. neoplasms. Blood 127:2375–2390.
Johnson NA, Slack GW, Savage KJ, Connors JM, Ben-Neriah S, Rogic S, et al. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project (1993). A
(2012). Concurrent expression of MYC and BCL2 in diffuse large B-cell predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med
lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, 329:987–994.
vincristine, and prednisone. J Clin Oncol 30:3452–3459. Tzankov A, Xu-Monette ZY, Gerhard M, Visco C, Dirnhofer S, Gisin N, et al.
Kawamoto K, Miyoshi H, Yoshida N, Nakamura N, Ohshima K, Sone H, et al. (2014). Rearrangements of MYC gene facilitate risk stratification in diffuse
(2016). MYC translocation and/or BCL 2 protein expression are associated large B-cell lymphoma patients treated with rituximab-CHOP. Mod Pathol
with poor prognosis in diffuse large B cell lymphoma. Cancer Sci 27:958–971.
107:853–861. Vose JM, Link BK, Grossbard ML, Czuczman M, Grillo-Lopez A, Gilman P, et al.
Kobayashi T, Tsutsumi Y, Sakamoto N, Nagoshi H, Yamamoto-Sugitani M, (2001). Phase II study of rituximab in combination with chop chemotherapy in
Shimura Y, et al. (2012). Double-hit lymphomas constitute a highly aggressive patients with previously untreated, aggressive non-Hodgkin’s lymphoma.
subgroup in diffuse large B-cell lymphomas in the era of rituximab. Jpn J Clin J Clin Oncol 19:389–397.
Oncol 42:1035–1042. Yan LX, Liu YH, Luo DL, Zhang F, Cheng Y, Luo XL, et al. (2014). MYC expression
Li S, Young KH, Medeiros LJ (2018). Diffuse large B-cell lymphoma. Pathology in concert with BCL2 and BCL6 expression predicts outcome in chinese
50:74–87. patients with diffuse large B-cell lymphoma, not otherwise specified. PLoS
Maura F, Guidetti A, Pellegrinelli A, Dodero A, Pennisi M, Caprioliet C, et al. One 8:e104068.
(2016). High-dose chemotherapy followed by autologous transplantation may Ye Q, Zijun Y, Xu-Monette ZY, Deng L, Wang X, Manyam GC, et al. (2015).
overcome the poor prognosis of diffuse large B-cell lymphoma patients with Prognostic impact of concurrent MYC and BCL6 rearrangements and
MYC/BCL2 co-expression. Blood Cancer J 6:e491. expression in de novo diffuse large B-cell lymphoma. Oncotarget 7:2401–2416.

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