HOSPITAL GENERAL DE ZONA NO.

47
MEDICINA INTERNA
MODULO: HEMATOLOGÍA

Síndromes mieloproliferativos
PROF TITULAR: DRA. ANA CRISTINA CALZADA RASCÓN
COORDINADOR: DR. CARLOS DE JESÚS MALDONADO
R1MI: DR. IVÁN GONZÁLEZ GODÍNEZ
HEMATOPOYESIS

Adaptado de Khwaja A, Bjorkholm M, Gale R, Levine R, Jordan C, Ehninger G, et al, Acute Myeloid Leukaemia, Nature Reviews, 2016;2:1-22
Línea
mieloide

Adaptado de Khwaja A, Bjorkholm M, Gale R, Levine R, Jordan C, Ehninger G, et al, Acute Myeloid Leukaemia, Nature Reviews, 2016;2:1-22
OMS 2016

Tefferi et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Tefferi A et al. Myeloproliferative Neoplasms: A Contemporary Review. JAMA Oncol. 2015;1(1):97-105. doi:10.1001/jamaoncol.2015.89
Mutaciones

Tefferi A et al. Myeloproliferative Neoplasms: A Contemporary Review. JAMA Oncol. 2015;1(1):97-105. doi:10.1001/jamaoncol.2015.89
Kralovics et al. A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders. N Engl J Med 2005;352:1779-90.
HOFFMAN, R. (2009). Chapter 67: The Polycythemias. Hematology: basic principles and practice. Philadelphia, PA, Churchill Livingstone/Elsevier.
HOFFMAN, R. (2009). Chapter 67: The Polycythemias. Hematology: basic principles and practice. Philadelphia, PA, Churchill Livingstone/Elsevier.
Sobrevida 2001-2016

Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Incidencia SEERS 2001-2016

Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Incidencia PV 2001-2016

Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Policitemia Vera

Stuart et al. Polycythemia Vera. Am Fam Physician 2004: 69;2139-44,2146

 DDx

HOFFMAN, R. (2009). Chapter 67: The Polycythemias. Hematology: basic principles and practice. Philadelphia, PA, Churchill Livingstone/Elsevier.
HOFFMAN, R. (2009). Chapter 67: The Polycythemias. Hematology: basic principles and practice. Philadelphia, PA, Churchill Livingstone/Elsevier.
DDx

Tefferi et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
Incidencia TE edad diagnóstico 2001-2016

Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Trombocitosis esencial

Bleeker et al. Thrombocytosis: Diagnostic Evaluation, Thrombotic Risk Stratification, and Risk-Based
Management Strategies. doi:10.1155/2011/536062
Trombocitosis esencial

Carrillo-Esper R et al. Trombocitosis. Rev Invest Med Sur Mex, Octubre-

Diciembre 2013; 20 (4): 254-256
 DDx

Adams BD et al. Myeloproliferative Disorders and the Hyperviscosity Syndrome. Emerg Med Clin N Am 27 (2009) 459–476
Trombocitosis esencial

Ferré OJ et al. Síndromes mieloproliferativos. Medicine. 2016;12(21):1213-23.

Carrillo-Esper R et al. Trombocitosis. Rev Invest Med Sur Mex, Octubre-Diciembre 2013; 20 (4): 254-256
Abordaje

Wong et al. Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient. Int J Lab Hematol. 2019;41(Suppl. 1):142–150
Tefferi et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
Criterios diagnósticos OMS 2016

Tefferi et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
Tefferi A et al. Myeloproliferative Neoplasms: A Contemporary Review. JAMA Oncol. 2015;1(1):97-105. doi:10.1001/jamaoncol.2015.89
Hidroxiurea
Mielofibrosis

Wong et al. Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient. Int J Lab Hematol. 2019;41(Suppl. 1):142–150
Incidencia de MF 2001-2016

Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
Arber et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. (Blood.
2016; 127(20):2391-2405)
Arber et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. (Blood. 2016; 127(20):2391-2405)
Arber et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. (Blood. 2016; 127(20):2391-2405)
International Working Group for MPN Research
and Treatment (IWG-MRT)

Tefferi et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
Tefferi A et al. Myeloproliferative Neoplasms: A Contemporary Review. JAMA Oncol. 2015;1(1):97-105. doi:10.1001/jamaoncol.2015.89
 REFERENCIAS

 Adaptado de Khwaja A, Bjorkholm M, Gale R, Levine R, Jordan C, Ehninger G, et al, Acute Myeloid Leukaemia, Nature Reviews, 2016;2:1-22
 Rory M et al. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020.
 Stuart et al. Polycythemia Vera. Am Fam Physician 2004: 69;2139-44,2146
 HOFFMAN, R. (2009). Chapter 67: The Polycythemias. Hematology: basic principles and practice. Philadelphia, PA, Churchill Livingstone/Elsevier.
 Kralovics et al. A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders. N Engl J Med 2005;352:1779-90.
 Tefferi A et al. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019;94:133–143.
 Tefferi A et al. Myeloproliferative Neoplasms: A Contemporary Review. JAMA Oncol. 2015;1(1):97-105. doi:10.1001/jamaoncol.2015.89
 Ferré OJ et al. Síndromes mieloproliferativos. Medicine. 2016;12(21):1213-23
 Wong et al. Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient. Int J Lab Hematol. 2019;41(Suppl. 1):142–150
 Adams BD et al. Myeloproliferative Disorders and the Hyperviscosity Syndrome. Emerg Med Clin N Am 27 (2009) 459–476
 Carrillo-Esper R et al. Trombocitosis. Rev Invest Med Sur Mex, Octubre-Diciembre 2013; 20 (4): 254-256