GRISEOFULVIN BIOSYNTHESIS VIA ACETATE PATH WAY

biosynthesis of griseofulvin as from penicillium griseofulvin fermentation via iterative addition

of 6 malonyl CoA to acyl CoA, through 14 C poly β keto chain by enzyme aromatase to aromatise
and aldol condense to a benzophenone intermediate that is methylated via S adenosyl
methionine to griseofulvin C. Ortho halogenation of the left aromatic ring to form
griseophenone B. This undergoes oxidation on both rings via a grisan skeleton ortho methylation
dehydrogriseofulvin that stereoselectively reduce the olefic by NADPH to griseofulvin.

ERYTHROMYCIN SYNTHESIS BY ACETATE PATH WAY

Erythromycin A from bacterium sacharopolyspora erythracea. Erythromycin A gene transfered

from S erythracea to E Coli to produce two erythromycin analogues. (2s) methyl malonyl CoA
and propionyl CoA. The 6d EB molecule is converted to erythromycin A via biosynthesis by the
deoxy sugar.
Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous
Host by Haoran Zhang etal

TETRACYCLINE BIO SYNTHESIS VIA ACETATE PATH WAY

Tetracycline fom the poly ketide path way from acetyl or malonyl CoA
BIOSYNTHESIS OF ARTEMESININ VIA ACETIC ACID ISOPRENYL PATH WAY