1.

1 Introduction
Chalcones 1,3-diphenyl-2-propen-1-ones , are based on two aryl moieties bridged via
an alpha,beta- unsaturated carbonyl group. These molecules have a -C=O-CH=CH-
ketoethylenic moiety in their structure, in their aromatic rings, they have a delocalized
pi-electron- containing order

(2017) Chalcone bearing pyrrole : Series of pyrrole-based chalcone derivatives were

reported through the classical Claisen–Schimdt condensation reaction protocol [1]. The
synthesized compounds displayed potential activity on the inhibition of CYP1
isoform, the reaction afford products of various derivatives 18 starting from aromatic
aldehyde derivatives A and pyrrole-based acetophenone B in basic media. The 2-
pyrrole chalcone derivatives C were possible to synthesize using either a liquid phase
or solid through a grinding method with moderate to good yields.

Chalcone bearing Imidazole : imidazole-based chalcone-substituted derivatives using

the Claisen–Schmidt condensation reaction between ethenone D and various para-
substituted aromatic aldehyde derivative D, A mixture of ethanone D and para-E
benzaldehyde 26 [2] in ethanol and aqueous potassium hydroxide was E and stirred at
room temperature. The resulting product was kept overnight in a refrigerator, and the
solid was filtered off, washed with water, and recrystallized from ethanol and
methanol to afford pure imidazole chalcone derivatives F

E
D
F
Chalcone bearing Pyridine : imidazo-pyridine derivatives through the condensation of
aryl methyl ketone and aryl aldehyde in the presence of alcoholic alkali media [3] The
synthesis mixture of pyridine-3-carbaldehyde G and ethenone H was refluxed in
methanol, followed by the addition of NaOH as a catalyst. The crude was poured on
to crushed ice, and the resulting product was further recrystallized from
dichloromethane to give compound I.

I
H G

Chalcone Bearing piperazine : synthesis of piperazine-chalcone hybrid derivatives as

potential vascular endothelial growth factor receptor-2 inhibitors [4] A mixture of a
derivative of acetophenone J and corresponding aldehyde derivatives K was dissolved
in 10% alcoholic sodium hydroxide and stirred at room temperature. After the
reaction completed, the precipitate was filtered, washed, dried, and recrystallized from
ethanol to afford the target compounds L.

J
K

L
Chalcone Bearing Benzimidazole : A series of benzimidazole-based chalcone
derivatives were synthesized and reported using the Claisen–Schmidt reaction as
potential Topo II-targeting anticancer agents [5] . Benzimidazole derivative N was
obtained through refluxing o-phenylenediamine M with glycolic acid in the presence
of HCl. The substituted benzimidazole-2-methanol O was synthesized through the
alkylation of compound N using a benzyl bromide in the presence of K 2CO3.
Subsequently, substituted benzimidazole-2-carbaldehyde derivatives P were obtained
from O through oxidation using a Dess–Martin protocol. Compounds O were finally
prepared from P through a Claisen–Schmidt reaction in the presence of appropriate
acetophenone derivatives.

M N O

Chalcone Bearing Quinoline : A series of quinoline-based chalcone derivatives were

synthesized and reported by Thirumurugan and co-workers through the common aldol
condensation reaction[6] Quinoline-based chalcones N-quinoline-2-carboxamides
were synthesized using quinoline-2-carboxylic acid Q subjected to ethenone R in
TEA using TBTU as the base with reflux for 3 h at room temperature .
 Q

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