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QUINOLINE
ISOQUINOLINE
INDOLE
QUINOLINE
INTRODUCTION
Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N.
It is a colourless hygroscopic liquid with a strong odour.
Aged samples, especially if exposed to light, become yellow and later brown.
Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most
organic solvents.
Quinoline itself has few applications, but many of its derivatives are useful in diverse
applications.
A prominent example is quinine, an alkaloid found in plants.
Over 200 biologically active quinoline and quinazoline alkaloids are identified.
4-Hydroxy-2-alkylquinolines (HAQs) are involved in antibiotic resistance.
CONTI…
The nitrogen lone pair electrons reside in an SP2 orbital and not involved in the
formation of the delocalized π molecular orbital.
It shows aromatic properties because its π orbital contains ten electrons & satisfied the
Huckel’s rule (n = 2 is 4n+2).
PHYSIAL PROPERTIES
3. Doebner reaction using anilines with an aldehyde and pyruvic acid to form quinoline-
4-carboxylic acids
4. Doebner-Miller reaction using anilines and α,β-unsaturated carbonyl compounds.
5. Gould-Jacobs reaction starting from an aniline and ethyl ethoxy methylene malonate
6. Skraup synthesis using ferrous sulfate, glycerol, aniline, nitrobenzene, and sulfuric
acid.
7. Friedländer synthesis using 2-aminobenzaldehyde and acetaldehyde
CONTI…
SKRAUP SYNTHESIS
In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol,
and an oxidizing agent such as nitrobenzene to yield quinoline.
MECHANISM
DOEBNER–MILLER SYNTHESIS
The reaction is catalyzed by Lewis acids such as tin tetrachloride and scandium(III)
triflate and Brønsted acids such as p-toluenesulfonic acid, perchloric acid, amberlite and iodine.
CONRAD–LIMPACH SYNTHESIS
The Conrad–Limpach synthesis is the condensation of anilines (1) with β-ketoesters (2) to
form 4-hydroxyquinolines (4) via a Schiff base (3). The overall reaction type is a combination of
both an addition reaction as well as a rearrangement reaction.
MECHANISM
FRIEDLÄNDER SYNTHESIS
3. OXIDATION
4. REDUCTION
5. HETEROATOM REACTION
ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUTION
REACTIONS
Electrophilic substitution reactions occur on the ring C-atoms, mainly on those of the more activated benzene
moiety.
Nucleophilic substitution of quinoline occurs in the electron deficient pyridine ring, as a rule in the position 2
or 4.
At 220°C quinoline8sulphonic acid is formed predominantly; At 300°C, quinoline6sulphonic acid is the sole
product.
When heating to 300°C quinoline8sulphonic acid is converted into quinoline6sulphonic, which is the
thermodynamically favoured Sulphonation product.
OXIDATION AND REDUCTION REACTIONS.
The alkaline permanganate solution causes oxidative cleavage of the benzene ring in
quinoline to give quinolinic acid (pyridine 2,3-dicarboxylic acid). The reaction of
quinoline with per-oxy carboxylic acids leads to its N-oxide.
Heteroatom reactions: The nitrogen in Quinoline, which undergoes protonation,
alkylation, acylation, etc. Quinoline is a weaker base than pyridine.
CONTI…
APPLICATION
1. Quinoline is used in the manufacture of dyes, the preparation of hydroxyquinoline sulphate and niacin.
4. Its principal use is as a precursor to 8-hydroxyquinoline, which is a versatile chelating agent and
precursor to pesticides.
5. Its 2- and 4-methyl derivatives are precursors to cyanine dyes. Oxidation of quinoline affords quinolinic
acid (pyridine-2,3-dicarboxylic acid), a precursor to the herbicide sold under the name "Assert".
6. The reduction of quinoline with sodium borohydride in the presence of acetic acid is known to
produce Kairoline A.
7. Quinoline has several anti-malarial derivatives, including quinine, chloroquine, amodiaquine,
and primaquine.
8. Quinolines are reduced to tetrahydroquinolines enantio-selectively using several catalyst systems.
ANY QUESTION ?
ISOQUINOLINE
INTRODUCTION
Iso-quinoline is a crystalline substance with a quinoline like odour; Its melting point is
24.6°C.
STRUCTURE OF ISOQUINOLINE
PHYSICAL PROPERTIES
1. Pomeranz–Fritsch reaction
2. Bischler–Napieralski reaction
1. POMERANZ–FRITSCH REACTION
The reaction is most notably used in the synthesis of dihydro iso-quinolines, which can be
subsequently oxidized to iso-quinolines.
MECHANISM
This mechanistic variance stems from the ambiguity over the timing for the elimination of
the carbonyl oxygen in the starting amide.
In Mechanism I, the elimination occurs with imine formation after cyclization; while in Mechanism II,
the elimination yields the nitrilium intermediate prior to cyclization.
Currently, it is believed that reaction conditions affect the prevalence of one mechanism over the other
(see reaction conditions).
In certain literature, Mechanism II is augmented with the formation of an imidoyl chloride intermediate
produced by the substitution of chloride for the Lewis acid group just prior to the nitrilium ion.
Because the dihydro iso-quinoline nitrogen is basic, neutralization is necessary to obtain the deprotonated
product.
MECHANISM
MECHANISM
CHEMICAL REACTION
3. Reduction reactions
4. Oxidation reactions
1. Alkylation and acylation occur on nitrogen
2. Reactions of electrophilic and nucleophilic substitution
Similarly to quinoline electrophilic substitution reactions occur mainly in the 5or 8 position of iso-quinoline
CONTI…
Nucleophilic reactions take place on the heterocyclic ring, prefer ably in the 1-position.
3. Reduction reactions
Oxidation of iso-quinoline with alkaline permanganate solution yields a mixture of phthalic acid and pyridine3,4-
dicarboxylic acid.
APPLICATION
i. Have basic, pyridine like nitrogen atoms, which undergo electrophilic substitutions.
ii. Are less reactive toward electrophilic substitution than benzene because of the nitrogen atom that
withdraws electrons from the ring.
iii. Electrophilic substitution occurs on the benzene ring rather than on the nitrogen-containing pyridine
ring and a mixture of substitution products is obtained.
ring thus few are available for Electrophilic Aromatic Substitution (EAS),
Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.
At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes.
Unlike most amines, indole is not basic: just like pyrrole, the aromatic character of the ring means that
the lone pair of electrons on the nitrogen atom is not available for protonation.
Indole is primarily protonated at the C3, rather than N1, owing to the enamine-like reactivity of the
portion of the molecule located outside of the benzene ring.
The protonated form has a pKa of −3.6. The sensitivity of many indolic compounds (e.g., tryptamines)
under acidic conditions is caused by this protonation.
PHYSICAL PROPERTIES
Chemical C8H7N
formula
Molar mass 117.151 g·mol−1
Appearance White solid
Odour Feces or jasmine like
Density 1.1747 g/cm3, solid
Melting point 52 to 54 °C (126 to 129 °F;
325 to 327 K)
Boiling point 253 to 254 °C (487 to
489 °F; 526 to 527 K)
Solubility in 0.19 g/100 ml (20 °C)
water Soluble in hot water
Acidity (pKa) 16.2 (21.0 in DMSO)
Basicity (pKb) 17.6
SYNTHESIS
2. Madelung synthesis
1. FISCHER INDOLE SYNTHESIS
The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a
(substituted) phenyl hydrazine and an aldehyde or ketone under acidic conditions.
Brønsted acids such as HCl, H2SO4, polyphosphoric acid and p-toluene sulfonic acid have been used
successfully.
MECHANISM
The reaction of a (substituted) phenyl hydrazine with a carbonyl (aldehyde or ketone) initially forms
a phenylhydrazone which isomerizes to the respective enamine (or 'ene-hydrazine’).
The resulting imine forms a cyclic amino-acetal (or aminal), which under acid catalysis eliminates NH3,
resulting in the energetically favourable aromatic indole.
Isotopic labelling studies show that the aryl nitrogen (N1) of the starting phenyl hydrazine is incorporated
into the resulting indole.
CONTI…
2. MADELUNG SYNTHESIS
The Madelung synthesis is a chemical reaction that produces (substituted or unsubstituted) indoles by
the intramolecular cyclization of N-phenyl amides using strong base at high temperature.
MECHANISM
The reaction begins with the extraction of a hydrogen from the nitrogen of the amide substituent and the extraction
of a benzylic hydrogen from the substituent ortho to the amide substituent by a strong base.
Next, the carbanion resulting from the benzylic hydrogen extraction performs a nucleophilic attack on
the electrophilic carbonyl carbon of the amide group. When this occurs, the pi-bond of the amide is converted into
a lone pair, creating a negatively charged oxygen.
After these initial steps, strong base is no longer required and hydrolysis must occur.
The negatively charged nitrogen is protonated to regain its neutral charge, and the oxygen is protonated twice to
harbor a positive charge in order to become a good leaving group.
A lone pair from the nitrogen forms a pi-bond to expel the positively charged leaving group, and also causes the
nitrogen to harbor a positive charge.
The final step of the reaction is an elimination reaction (specifically an E2 reaction), which involves the extraction
of the other hydrogen that was once benzylic, before the bicyclic compound was formed, whose electrons are
converted into a new pi-bond in the ring system.
This allows the pi-bond formed by nitrogen in the preceding step to be converted back into a lone pair on nitrogen
to restore nitrogen's neutral charge.
MECHANISM
CHEMICAL REACTION
Electrophilic addition to N
Electrophilic substitution
Oxidation
Reduction
Mannich reaction
1. ELECTROPHILIC ADDITION TO N
2. ELECTROPHILIC SUBSTITUTION
The most reactive position on indole for electrophilic aromatic substitution is C3, which is
10000000000000 times more reactive than benzene.
For example, it is alkylated by phosphorylated serine in the biosynthesis of the amino acid
tryptophan. Vilsmeier–Haack formylation of indole will take place at room temperature exclusively at C3.
Due to the electron-rich nature of indole, it is easily oxidized. Simple oxidants such as N-bromo
succinimide will selectively oxidize indole 1 to oxindole (4 and 5).
N O3 , H2O
H NHCOH
4. REDUCTION
5. MANNICH REACTION
Indole undergo Mannich reaction with formaldehyde and dimethyl amine to give 3 – dimethylamine
indole.
CH3
H O CH3 CH2 - N
HCl
+ H-C- H + HN CH3
N CH3 - H2O N
H
H
3 - dimethylamino methylindole
MECHANISM OF MANICH REACTION
APPLICATION
REFERENCE
1. https://www.researchgate.net/publication/325080072_UNIT_-V_Heterocyclic_Chemistry_Quinoline_Isoquinoline_and_Indole
2. https://en.wikipedia.org/wiki/Quinoline
3. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The
Royal Society of Chemistry. 2014. pp. 4, 211. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. The name
‘quinoline’ is a retained name that is preferred to the alternative systematic fusion names ‘1-benzopyridine’ or
‘benzo[b]pyridine’.
4. Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic
Press, New York, 1955.
5. Shang, XF; Morris-Natschke, SL; Liu, YQ; Guo, X; Xu, XS; Goto, M; Li, JC; Yang, GZ; Lee, KH (May 2018). "Biologically
active quinoline and quinazoline alkaloids part I."Medicinal Research Reviews. 38 (3): 775-828.
doi:10.1002/med.21466. PMC 6421866. PMID 28902434.
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Jun-Cai; Zhang, Ji-Yu; Lee, Kuo-Hsiung (September 2018). "Biologically active quinoline and quinazoline alkaloids part
II". Medicinal Research Reviews. 38 (5): 1614–1660. doi:10.1002/med.21492. PMC 6105521. PMID 29485730.
7. F. F. Runge (1834) "Ueber einige Produkte der Steinkohlendestillation" (On some products of coal distillation), Annalen der
Physik und Chemie, 31 (5) : 65–78 ; see especially p. 68: "3. Leukol oder Weissöl" (3. White oil [in Greek] or white oil [in
German]). From p. 68:"Diese dritte Basis habe ich Leukol oder Weissöl genannt, weil sie keine farbigen Reactionen
zeigt." (This third base I've named leukol or white oil because it shows no color reactions.)
8. Jump up to: Gerd Collin; Hartmut Höke. "Quinoline and Isoquinoline". Ullmann's Encyclopedia of Industrial Chemistry
Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_465.
REFERENCE
9. Gerhardt, Ch. (1842) "Untersuchungen über die organischen Basen" (Investigations of organic bases), Annalen der Chemie und
Pharmacie, 42 : 310-313. See also: (Editor) (1842) "Chinolein oder Chinoilin" (Quinoline or quinoilin), Annalen der Chemie und
Pharmacie, 44 : 279-280.
10. Initially, Hoffmann thought that Runge's Leukol and Gerhardt's Chinolein were distinct. (See: Hoffmann, August Wilhelm
(1843) "Chemische Untersuchungen der organischen Basen im Steinkohlen-Theeröl" (Chemical investigations of organic bases in
coal tar oil), Annalen der Chemie und Pharmacie, 47 : 37-87 ; see especially pp. 76-78.) However, after further purification of
his Leukol sample, Hoffmann determined that the two were indeed identical. (See: (Editor) (1845) "Vorläufige Notiz über die
Identität des Leukols und Chinolins" (Preliminary notice of the identity of leukol and quinoline), Annalen der Chemie und
Pharmacie, 53 : 427-428.)
11. O'Loughlin, Edward J.; Kehrmeyer, Staci R.; Sims, Gerald K. (1996). "Isolation, characterization, and substrate utilization of a
quinoline-degrading bacterium". International Biodeterioration & Biodegradation. 38 (2): 107. doi:10.1016/S0964-
8305(96)00032-7.
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Alkylation of Quinoline and Isoquinoline with Carboxylic Acids". Synthesis. 1975 (10): 650–652. doi:10.1055/s-1975-
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13. Xu, L.; Lam, K. H.; Ji, J.; Wu, J.; Fan, Q.-H.; Lo, W.-H.; Chan, A. S. C. Chem. Commun.2005, 1390.
14. Reetz, M. T.; Li, X. Chem. Commun. 2006, 2159.
15."QUINOLINE (BENZOPYRIDINE)". Chemicalland21.com. Retrieved 2012-06-14.
16.Jump up to: Chisholm, Hugh, ed. (1911). "Quinoline" . Encyclopædia Britannica. 22 (11th ed.). Cambridge University Press.
p. 759.
REFERENCE
17. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal
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Academic Press, New York, 1955.
19. Gilchrist, T.L. (1997). Heterocyclic Chemistry (3rd ed.). Essex, UK: Addison Wesley Longman.
20. Harris, J.; Pope, W.J. "isoQuinoline and the isoQuinoline-Reds" Journal of the Chemical Society (1922) volume 121, pp. 1029–1033.
21. Katritsky, A.R.; Pozharskii, A.F. (2000). Handbook of Heterocyclic Chemistry (2nd ed.). Oxford, UK: Elsevier.
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1995 (Vol. 5). Tarrytown, NY: Elsevier.
23. Nagatsu, T. "Isoquinoline neurotoxins in the brain and Parkinson's disease" Neuroscience Research (1997) volume 29, pp. 99–111.
REFERENCE
24. https://ars.els-cdn.com/content/image/1-s2.0-S092809871630207X-fx1_lrg.jpg
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Access to Underexplored Indole Core Structures". Org. Lett. 14: 2610.
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