Preparation of glycerophosphoric acid
RESUMEN
The preparation of glycerophosphoric acid uses med-
icine-level glycerine and food-level phosphoric acid
in the molar ratio not greater than 1 as material and
includes their reaction at 120-150 deg.C and vacuum
state for 4-7 hr, and the cooling, hydrolysis with de-
ionized water and decoloring with carboraffin of
reacted solution, filtering and packing. The present
invention has simple technological process and high
material conversion rate.
DESCRIPCIÓN traducido del chino
Preparation of glycerophosphate
The present invention relates to a method for prepar-
ing glycerol phosphate.
Can be used in the manufacture of glycerol phosphate
salts as nutritional supplements, the international
advanced production process vitamin B12 must also
use glycerol phosphate, and yet this coun-
try glycerol phosphate production technology.
The object of the present invention is to overcome the
inadequacy of the prior art to provide a method for
preparing glycerol phosphate, the method is simple,
raw material conversion rate.
The object of the present invention is achieved by the
following scheme: Preparation of glycerophosphate
with pharmaceutical grade glycerine and food grade
phosphoric acid as raw materials, the two ingredients
ratio (molar ratio) of: glycerol: acid ≤ 1.0, with the
above Glycerol and the ratio of phosphoric acid, a
reaction temperature of 120 ℃ -150 ℃, the reaction
pressure is vacuum, the reaction time is 4-7 hours, the
1
reaction solution after cooling, add deionized water
hydrolysis, and then decolorizing carbon sugar level ,
then filtered and packaging.
The method of production of α-glycerophosphate
acids is an asymmetric and symmetric β-acid mix-
ture, which is percentage of the total amount of the
mixture.
After more than 200 practice test batch, the present
invention has the following advantages: 1, the present
invention produces glycerol phosphate, up by Hebei
Wei Pharmaceutical Co., Ltd. three years of produc-
tion practice verification, full compliance with the
company's production of vitamin B12 production
process requirements , and the method of production
of glycerol phosphate, quality and stability, Jinzhou
large chemical enterprise standards still Q/JDS01-
1996, key indicators: ① glycerol phosphate con-
tent% ≥ 35 ② free phosphoric acid (as P2O5) con-
tent% ≤ 5 ③ heavy metals (as Pb) content% ≤ 0.001
④ Arsenic (as As) content% ≤ 0.0005 ⑤ colorless
or pale yellow clear transparent liquid.
2, the product yield. Per ton to produce pharmaceuti-
cal grade glycerine glycerol phosphate containing
4.6-5 tons more than 35% of the products in the best
conditions, product yield (in glycerol meter) up to
95% -99%.
3, the process is simple.
The following describes the present invention in one
particular embodiment: the 250 kg and 298 kg phar-
maceutical grade glycerine food grade phosphoric
acid into the reaction tank, stirring, vacuum, heating
to 140 ℃, 4 hours the reaction was completed, the
cooling add deionized water, hydrolysis, Stir sugar
level with 4 kg active carbon, activated charcoal and
filtered to remove impurities, producing 1000 kg
product, after testing glycerophosphate content of
35.3%, free phosphoric acid (as P2O5) content of
3.3%, the product yield ( glycerin meter) was
97.73%.

RECLAMACIONES(2) traducido del chino

A method for preparing glycerol phosphate, charac-

terized in that it uses pharmaceutical grade glycerine
and food grade phosphoric acid as raw materials, the
two ingredients ratio (molar ratio) of: glycerol: phos-
phorylated ≤ 1.0; the above proportions
of glycerol and phosphate a reaction temperature of
120 ℃ -150 ℃, the reaction pressure is vacuum, the
reaction time is 4-7 hours; the reaction solution after
cooling, add deionized water hydrolysis, and then
active carbon sugar level, and then filtered, pack-
aged .

(2) as claimed in claim 1 for preparing glycerophos-

phate, characterized in that the product of the activat-
ed carbon used in an amount of 0.3% -0.5% by
weight.

Preparación del beta glicerofosfato

Esterification of glycerol with phosphoric acid at

100° C. under normal pressure produces mainly the
alpha isomer. If the glycerol is esterified by heating
with sodium dihydrogen phosphate the beta isomer is
the principal product. The two isomers are intercon-
vertible in acid solution but stable in the presence of
alkali.