COURSE SYLLABUS

COURSE CODE : E-TOXI 102

DESCRIPTIVE TITLE : ENVIRONMENTAL TOXICOLOGY

COURSE DESCRIPTION : Environmental toxicology is the study of toxic

effects of environmental chemicals on living organisms
(including humans). In this course, the basic concepts,
methods, and approaches in environmental toxicology
will be introduced. Natural and synthetic chemicals
commonly encountered in the air, water, and soil will
be discussed regarding their occurrence, fate and
transport, and toxicological effects on ecological
species and humans. Case studies will be used to
illustrate the complexity of environmental toxicology
issues. New trends in chemical toxicity testing will be
discussed. Contaminants of emerging concerns such as
pharmaceutical and personal care products and
engineered nanomaterials will also be introduced.

COURSE CREDIT : 4 units ( 2 units lecture, 2 units laboratory)

CONTACT HOURS : 2 hours lecture and 3 hours laboratory

Total of 34 hours lecture and 51 hours laboratory per
semester

PREREQUISITES : None

PLACEMENT : 3rdt Year, First Semester

COURSE OUTCOMES:
At the end of the course, the student should be able to:

1. Critically evaluate and interpret scientific data, information, and lab results

2. Write and clearly present key aspects of fundamental toxicology and the discipline’s
relevancy to real-world issues

3. Utilize scientific literature and databases to identify information needed to

understand and effectively communicate aspects of toxicology

4. Master a broad set of [toxicology] knowledge concerning the fundamentals in the

basic areas of toxicology

5. Demonstrate an understanding of legal, regulatory, and ethical considerations

relating to toxicology within the broader societal context

6. Demonstrate an understanding of and the ability to apply the scientific method in

gaining technical expertise and lab skills

7. Demonstrate knowledge on the foundation of histology as well as inclusive methods

of determining various estimations of toxicity

8. Demonstrate events in toxicosis and compare approaches in the estimation of health

effects

Page 1
Environmental Toxicology 1st Semester Syllabus

9. Outline steps of toxic risk assessments and demonstrate knowledge on the major
classes of pesticides and their associated environmental and human health risks.

Page 2
 COURSE SYLLABUS TEMPLATE
cdbd
Page 3 of 7
TEACHING-LEARNING STRATEGIES NO. OF TOOL RESOURCES
& ACTIVITIES HOURS
LEARNING OUTCOMES CONTENT ASSESSMENT
Classroom Laboratory Lec Lab
At the end of the unit, the Unit 1: Introduction to Interactive Online Quiz 2 3 Classroom: Ariens, E. (2000).
student must have: Toxicology Lecture Written Introduction to General
1. Master a broad set of Reading Online seatwork by pair Performance Toxicology. Academic
[toxicology] knowledge 1.1 Study of environmental Questioning Literature Evaluation Press, New York, NY.
concerning the Toxicology Laboratory: Checklist
fundamentals in the basic 1.2 Importance of Performance- Doull, J. (2011). Casarett
areas of toxicology Environmental Toxicology as an based evaluation Rating Scale and Doull's Toxicology:
Area of Science The Basic Science of
Poisons. Macmillan
Publishing Co., Inc., New
York, NY.
At the end of the unit, the Unit 2: Environmental Lecture- Reading Online 2 3 Classroom: Answer Keys National Institute for
student must have: Changes and Health Discussion Literature Paper and Pencil Occupational Safety and
1. In-depth knowledge on Test employing Oral Exam Health (2010). Registry
the various environmental 2.1 Our Changing Environment Submission of Selected Rubrics of Toxic Effects of
changes related to 2.2 Air Pollution Online Response (MCQ) Chemical Substances.
toxicology 2.3 Indoor Air Pollution Assignment DHHS (NIOSH)
2.4 Water Pollution Laboratory: Performance Publication No. 83-107,
2. Knowledge differentiate 2.5 Soil Pollution Online Quiz Paper and Pencil Evaluation Volumes 1-3, U.S.
and describe each type of 2.6 The Changing Diseases Test Checklist Government Printing
pollution that cause Participation in Office, Washington, DC.
environmental changes Online Poll Rating Scale
Loomis, T. (2008).
Graded Essentials of Toxicology.
Simulations Lea and Febiger,
Philadelphia, PA.
Internet resource
list

Laboratory
Activity
Present.Me
Prezi Presentation

At the end of the unit, the Unit 3: Occurrence of Lecture- Graded 2 3 Classroom: Answer Keys Ariens, E. (2000).
student must have: Toxicants Demonstration Simulations Group reporting Introduction to General
1. Understanding of the 5 members per Oral Exam Toxicology. Academic
various effects and 3.1 Visible Smog or Smog Reflection Submission of group Rubrics Press, New York, NY.
damages of visible smogs 3.2 Offensive Odors Online
or smogs 3.3 Agricultural Damage Assignment Laboratory: Doull, J. (2011). Casarett
3.4 Agricultural Damage Performance- and Doull's Toxicology:
2. In-depth knowledge of 3.5 Intoxication of Animals Based Evaluation The Basic Science of

Page 3
 COURSE SYLLABUS TEMPLATE
cdbd
Page 4 of 7
the process of smog 3.6 Injuries to Humans Poisons. Macmillan
formation and the 3.7 Chronic and Acute Effects Publishing Co., Inc., New
description of its York, NY.
components

At the end of the unit, the Unit 4: Toxic Action Lecture- Graded 2 3 Classroom: Rating Scales Loomis, T. (2008).
student must have: Pollutants Discussion Simulations Paper and Pencil Essentials of Toxicology.
1. Masterful knowledge Test employing Performance Lea and Febiger,
concerning the process of 4.1 Effects on Plants Questioning Online quiz Selected Evaluation Philadelphia, PA.
toxic action 4.2 Mammalian Organisms Response (MCQ) Check list
4.3 Mechanism of Toxic Action Doull, J. (2011). Casarett
2. Ability to determine the Laboratory: and Doull's Toxicology:
effects of toxic action Online The Basic Science of
towards various oganisms assessment tool Poisons. Macmillan
Group activity Publishing Co., Inc., New
York, NY.
At the end of the unit, the Group Reporting Prezi Presentation 2 3 Classroom: Oral Exam National Institute for
student must have: Unit 5: Factors Affecting Group reporting Rubrics Occupational Safety and
1. Ability to determine the Xenobiotic Action Reading online 5 members per Health (2010). Registry
appropriate amount of literature group of Toxic Effects of
dose/concentration of 5.1 Physiological Properties Performance Chemical Substances.
xenobiotics for the desired 5.2 Dose or Concentration Laboratory: Evaluation DHHS (NIOSH)
xenobiotic action 5.3 Duration and Mode of Performance- Check list Publication No. 83-107,
Exposure Based Evaluation Volumes 1-3, U.S.
2. Knowledge of the 5.4 Environmental Factors Government Printing
various factors that affect 5.5 Interaction Office, Washington, DC.
xenobiotic action 5.6 Biological Factors
5.7 Nutritional Factors Loomis, T. (2008).
Essentials of Toxicology.
Lea and Febiger,
Philadelphia, PA.
At the end of the unit, the Interactive Online quiz 2 3 Classroom: Answer keys Zakrzewski, S. (2011).
student must have: Unit 6: Biotransformation: Lecture Paper and Pencil Principles of
1. Comprehension of the Metabolism of Xenobiotics Test employing Performance Environmental
biotransformation process Graded Simulation Selected Evaluation Toxicology; American
as a result of the 6.1 Types of Biotransformation Response (MCQ) Check list Chemical Society:
metabolism of xenobiotics 6.2 Mechanism of Washington, DC.
Biotransformation Laboratory:
6.3 Characteristics of Online research Doull, J. (2011). Casarett
Biotransformation and data and Doull's Toxicology:
6.4 Consequence of gathering The Basic Science of
Biotransformation Poisons. Macmillan
6.5 Factors Affecting Publishing Co., Inc., New
Biotransformation York, NY.
6.6 Characteristics of the
Cytochrome P450s

At the end of the unit, the Unit 7: Responses to Lecture- Participation in 2 3 Classroom: Rating Scale Ariens, E. (2000).

Page 4
 COURSE SYLLABUS TEMPLATE
cdbd
Page 5 of 7
student must have: Environmental Toxicants Discussion online poll Written quiz Introduction to General
1. Knowledge of the Toxicology. Academic
various responses of 7.1 Responses of Plants Questioning Laboratory: Press, New York, NY.
plants, humans, and 7.2 Responses of Humans and Moving practical
animals towards Animals exam Loomis, T. (2008).
environmental toxicants Essentials of Toxicology.
Lea and Febiger,
Philadelphia, PA.
At the end of the unit, the Unit 8: Air Pollution: Group Reporting Online quiz 2 3 Classroom: Answer keys Gosselin, R & Smith, R
student must have: Inorganic Gases Group reporting (2009). Clinical
1. Ability to identify Submission of 5 members per Rating Scale Toxicology of
inorganic gases that cause 8.1 Sulfur Dioxide Online group Commercial Products,
air pollution 8.2 Nitrogen Dioxide Assignement 5th ed.; Williams and
8.3 Ozone Laboratory: Williams: Baltimore.
8.4 Carbon Monoxide Performance-
Based Evaluation Doull, J. (2011). Casarett
and Doull's Toxicology:
The Basic Science of
Poisons. Macmillan
Publishing Co., Inc., New
York, NY.
At the end of the unit, the Unit 9: Air Pollution: Lecture- Submission of 2 3 Classroom: Answer keys Fumento, M. (2007).
student must have: Particulate Matter Demonstration Online Paper and Pencil Science Under Siege:
1. Comprehension of the Assignment Test employing How the Environmental
process of particulate 9.1 Characteristics of Particulate Selected Misinformation
formation Matter Response (MCQ) Campaign Is Affecting
9.2 Formation of Particulates Our Laws, Taxes, and Our
2. Ability to explain the 9.3 Health Effects Daily Life; William
various characteristics of 9.4 Silica Laboratory: Morrow: New York.
particulate matter 9.5 Beryllium Online
9.6 Asbestos assessment tool Ariens, E. (2000).
3. Ability to identify and 9.7 Lead Group activity Introduction to General
determine various Toxicology. Academic
particulate matters that Press, New York, NY.
cause air pollution
At the end of the unit, the Unit 10: Environmental Group Reporting 2 3 Classroom: Perfromance Loomis, T. (2008).
student must have: Fluoride Reading online Group reporting evaulation Essentials of Toxicology.
1. Comprehension of the literature 5 members per checklist Lea and Febiger,
process of fluoride 10.1 Occurrence and Forms of group Philadelphia, PA.
formation, its sources, and Fluoride Oral Exam
its biochemical effects 10.2 Industrial Sources of Rubrics Doull, J. (2011). Casarett
Fluoride Pollution and Doull's Toxicology:
2. Ability to determine the 10.3 Effects on Plants Laboratory: The Basic Science of
effect of fluoride pollution 10.4 Effects on Animals Performance- Poisons. Macmillan
on various organisms 10.5 Effects on Humans Based Evaluation Publishing Co., Inc., New
10.6 Biochemical Effects of York, NY.
3. Ability to measure Fluoride
fluoride toxicity 10.7 Nutrition and Fluoride
Toxicity

Page 5
 COURSE SYLLABUS TEMPLATE
cdbd
Page 6 of 7
At the end of the unit, the Unit 11: Volatile Organic Lecture- Online Quiz 2 3 Classroom: Answer keys Oregon State University
student must have: Compounds Discussion Paper and Pencil Website. EXTOXNET: The
1. In-depth knowledge of Test employing Extension Toxicology
sources and types of 11.1 Sources Questioning Selected Network.
volatile organic 11.2 Petroleum Hydrocarbons Response (MCQ) www.ace.orst.edu/info/
compounds 11.3 Polycyclic Aromatic extoxnet
Hydrocarbons
Laboratory:
Online
assessment tool
Group activity

At the end of the unit, the Unit 12: Soil and Water Lecture- Submission of 2 3 Classroom: Answer Keys University of Edinburgh
student must have: Pollution: Environmental Discussion online assignment Written Occupational and
1. Understanding on the Metals and Metalloids seatwork Rating Scale Environmental Health
various metals and Individual Website. Tutorials.
metalloids and how they 12.1 Lead Toxicology. Introduction
cause soil and water 12.2 Cadmium to Applied Toxicology.
pollution 12.3 Mercury http://www.link.med.ed.
12.4 Nickel ac.uk/hew/tox/default.h
12.5 Arsenic tm

At the end of the unit, the Week 13: Pesticides and Lecture- Laboratory 2 3 Classroom: Rating Scales Ariens, E. (2000).
student must have: Related Materials Demonstration Activity Paper and Pencil Introduction to General
1. Knowledge on the Test employing Oral Exam Toxicology. Academic
definition of pesticides 13.1 Insecticides Selected Rubrics Press, New York, NY.
and its various types and 13.2 Herbicides Response (MCQ)
examples 13.3 Polychlorinated Biphenyls
13.4 Polybrominated Biphenyls
13.5 Dioxin

At the end of the unit, the Week 14: Occupational Group Reporting Prezi Presentation 2 3 Classroom: Performance Loomis, T. (2008).
student must have: Toxicology Group reporting Evaluation Essentials of Toxicology.
1. Ability to assess Lecture Graded 5 members per Check list Lea and Febiger,
workplace condition in 14.1 Changing Workplace SImulation group Philadelphia, PA.
terms of toxic substance Environment
exposure 14.2 Threshold Limit Values Doull, J. (2011). Casarett
14.3 Biological Exposure Indices Laboratory: and Doull's Toxicology:
2. Knowledge of the 14.4 Respiratory Toxicity Performance- The Basic Science of
various occupational 14.5 Other Occupational Based Evaluation Poisons. Macmillan
diseases related to toxicity Diseases Caused by Toxic Publishing Co., Inc., New
Substances York, NY.
3. Awareness on the 14.6 Recent Chemicals of
recent chemicals of Concern
concern
At the end of the unit, the Week 15: Endocrine Lecture- Reading online 2 3 Classroom: Oral Exam Fumento, M. (2007).
student must have: Disruption Discussion literature Paper and Pencil Rubrics Science Under Siege:

Page 6
 COURSE SYLLABUS TEMPLATE
cdbd
Page 7 of 7
1. Ability to differentiate Test employing How the Environmental
endocrine disruptors from 15.1 Review of Hormonal Online quiz Selected Answer KEys Misinformation
other chemicals Function Response (MCQ) Campaign Is Affecting
15.2 Characteristics of Our Daily Life; William
2. Understanding of the Endocrine Disruptors Laboratory: Morrow: New York.
process of endocrine 15.3 Mode of Action Online
disruption and its various 15.4 Examples of Endocrine assessment tool Ariens, E. (2000).
examples Disruption By pair activity Introduction to General
15.5 Hormonal Cancers Toxicology. Academic
3. Mastery of the process 15.6 Testing Estrogenicity Press, New York, NY.
of estrogenicity testing

At the end of the unit, the Unit 16: Mutagenic Pollutants Prezi Presentation 2 3 Laboratory: Rating Scales Gosselin, R & Smith, R
student must have: Performance- (2009). Clinical
1. Full comprehension of 16.1 Types of Mutation Based Evaluation Performance Toxicology of
the process of mutation 16.2 Effects of Mutation Evaluation Commercial Products,
and its various types and 16.3 Induction of Mutation Checklist 5th ed.; Williams and
effects Williams: Baltimore.

Doull, J. (2011). Casarett

and Doull's Toxicology:
The Basic Science of
Poisons. Macmillan
Publishing Co., Inc., New
York, NY.
At the end of the unit, the Week 17: Environmental Interactive Online quiz 2 3 Classroom: Answer Keys National Institute for
student must have: Cancer Lecture Paper and Pencil Occupational Safety and
1. Full comprehension of Test employing Rating scales Health (2010). Registry
the process of the 17.1 Causes of Cancer Questioning Selected of Toxic Effects of
development of cancer 17.2 Three Stages in the Response (MCQ) Chemical Substances.
and its metastasis Development of Cancer DHHS (NIOSH)
17.3 Metastasis Laboratory: Publication No. 83-107,
2. Ability to classify 17.4 Classification of Moving Practical Volumes 1-3, U.S.
carcinogens and explain Carcinogens Exam Government Printing
the process of their 17.5 Metabolism of Chemical Office, Washington, DC.
metabolism Carcinogens
17.6 Respiratory Cancer Death Loomis, T. (2008).
3. Knowledge of the facts Rates Essentials of Toxicology.
concerning respiratory 17.7 DNA Repair Lea and Febiger,
cancer death rates and the Philadelphia, PA
process of DNA repair

Page 7