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Standard Operating Procedure: Titanium Tetrachloride
Standard Operating Procedure: Titanium Tetrachloride
Titanium tetrachloride
This is an SOP template and is not complete until the laboratory management has completed
the specific areas identified with red text. Print a copy and insert into your Laboratory Safety
Manual or Chemical Hygiene Plan.
Department:
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Date SOP was written:
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Date SOP was approved by PI/lab supervisor:
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Principal Investigator:
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Internal Lab Safety Coordinator/Lab Manager:
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Lab Phone:
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Office Phone:
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Purpose
Titanium tetrachloride is an acute toxin and corrosive.
May be harmful if ingested, inhaled, or absorbed through skin. May cause kidney, lung, or liver damage.
Severe overexposure can be fatal or cause nausea, dizziness, headache, tremors, and sweating.
Titanium tetrachloride is an intermediate in the production of titanium and titanium dioxide pigment.
CAS#: 7550-45-0
Color: clear
Potential Hazards/Toxicity
Titanium tetrachloride is an acute toxin.
Titanium tetrachloride is also a corrosive and irritant. Extremely hazardous in case of skin contact of eye
contact, ingestion, oor inhalation. Causes severe skin burns. Corrosion may cause pain, ulceration or
blisters, cracking or peeling of skin. Damage may be permanent.
Extremely corrosive and destructive to tissue. Liquid or vapor may damage mucous membranes and may
produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract,
characterized by coughing or shortness of breath. Skin inflammation can cause itching, scaling,
reddening, or, occasionally, blistering.
As a last line of defense (i.e., after engineering and administrative controls have been
exhausted).
When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will
be exceeded.
Regulations require the use of a respirator.
An employer requires the use of a respirator.
There is potential for harmful exposure due to an atmospheric contaminant (in the absence of
PEL)
As PPE in the event of a chemical spill clean-up process
Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S. This is a
regulatory requirement. http://www.asu.edu/ehs/documents/asu-respiratory-protection-
plan.pdf
Hand Protection
Gloves must be worn. Nitrile gloves are recommended.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are
compatible with Titanium tetrachloride.
Hygiene Measures
Wash thoroughly and immediately after handling. Remove contaminated clothing and wash before reuse.
Engineering Controls
Handle using a chemical fume hood with good ventilation and electrically grounded lines and equipment.
If swallowed
Do NOT induce vomiting unless directed by medical personnel. Never give anything by mouth to an
unconscious person. Seek medical attention immediately.
Precautions for safe handling: Avoid contact with skin and eyes and inhalation.
Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated. Keep away
from incompatible materials and conditions. Store in original container. Keep cool and protect from
sunlight.
Small (<1 Liter) – Follow the “Hazardous Materials Incident” guidance in the posted Emergency
Response Guide.
Large (>1 Liter) – Dial 911. Follow guidance for major spill or leak in the posted Emergency Response
Guide
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower
for at least 15 minutes. Seek medical attention. Notify supervisor and ASU EH&S at 480-965-1823.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the
emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention.
Notify supervisor and ASU EH&S at 480-965-1823.
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911. Note: all injuries and
incidents must be reported to ASU EH&S, 480-965-1823.
Non-Life Threatening Emergency –Report to your ASU campus health Services Center (451 E.
University Drive, south side of University Drive, west of Palm Walk, Hours: M-F, 8am – 6pm, Sat., 10am –
2pm). Outside of these hours, report to Tempe St. Luke’s ER, 1500 S. Mill Avenue. Note: all injuries and
incidents must be reported to ASU EH&S, 480-965-1823.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected
area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the
affected area for 15 minutes using an eyewash station. Report to your ASU campus Health Services
Center (451 E. University Drive, south side of University Drive, west of Palm Walk, Hours: M-F, 8am –
6pm, Sat., 10am – 2pm). Outside of these hours, report to Tempe St. Luke’s ER, 1500 S. Mill Avenue.
Note: all injuries and incidents must be reported to ASU EH&S, 480-965-1823.
Using proper personal protective equipment as outlined above, decontaminate equipment and bench tops
using soap and water and properly dispose of all chemical and contaminated disposables as hazardous
waste following the guidelines below.
Label Waste
Attach a completed ASU Hazardous Waste tag to all waste containers as soon as the first drop
of waste is added to the container.
Store Waste
Store hazardous waste in closed containers, in secondary containment and in a designated
location
Double-bag dry waste using transparent bags
Waste must be under the control of the person generating & disposing of it
NOTE
Prior to conducting any work regarding this SOP, Principal Investigator or designee must provide
to his/her laboratory personnel specific to the hazards involved in working with this substance,
work area decontamination, and emergency procedures.
The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and
a copy of the MSDS provided by the manufacturer.
The Principal Investigator must ensure that his/her laboratory personnel have attended
appropriate/required safety training (i.e. Biosafety, Fire Safety & Prevention, Hazardous Waste
Management, Laboratory Safety ) or refresher training within the last one year.