Daria is a 45 year female patient, she had an episode of symptomatic proximal deep vein

thrombosis last year. She is currently maintained on Rivaroxaban, to prevent further episode of venous
thromboembolism. She disclosed to you that she has found rivaroxaban expensive and went back to you
and asking if other anti-coagulant like aspirin would be effective in preventing recurrent venous
thromboembolism.

1. Create a clinical question? Using PICOM method

2. Give three key term or words which you will use for your search?

3. Compare your formulated PICOM with the study PICOM?

Your Question Study Material

P
I
C
O
M

Validity Guides:

Primary Validity Guides

4. Was the assignment of patient to treatment randomized?

5. Were all the patient who entered in the trial properly accounted for and attributed at its conclusion?

6. Were intention to treat analysis used?

Secondary Validity Guides

7. Were patient, their clinician and study personnel “blinded”?

8. Were the groups similar at the start of the trial?

9. Aside from the experimental intervention, were the groups treated equally?

10. Overall, was the treatment valid?

11. What are the results, How large was the treatment effect? Compute for the following:

a. Risk in treatment (RT)

b. Risk in control (RC)

c. Absolute Risk Reduction (ARR)

d. Relative Risk (RR)

e. Relative Risk Reduction (RRR)

f. Number needed to treat

12. How precise was the treatment effect?

13. Were all clinically important outcomes considered?

14. How can apply these results to Daria?