Professional Documents
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Concentrations
Educational Objectives
Review the units of measurement for drugs and expressions of quantity and concentration
for drugs in drug products.
Illustrate different methods for determining quantities of ingredients and concentration of
drugs when preparing or dispensing drug products.
Calculate the amounts of two solutions of different strengths, which must be combined to get
a third solution of a specified strength.
Calculate the final strength of a diluted or mixed solution when given the original strength
(s) and volume (s) and the final volume.
Expressions of Quantity
Milliequivalents (mEq)
A milliequivalent is equal to the number of univalent counter ions (H+ or OH) which will be
needed to react with one molecule of the substance
When an atom has a valence of one ( e.g. Na+, K+, CI, etc.) a mEq of that ion is equal to the
atomic weight of the atom in milligrams. For example, one mEq of sodium (Na+) with an
atomic weight of 23 (AW) weighs 23mg.
When an atom has a valence of two or more (e.g. Mg+2, Ca+2, Al+3) a mEq of that ion is
equal to the atomic weight of the atom in milligrams divided by the atom's valence. For
example, one mEq of calcium (Ca+2) with an atomic weight of 40 weight 20 mg.
Because in chemical compounds or salts ions always come in pairs, (positive and negative
ions are always together in salts like NaC1 and CaC12) we can never weigh or measure just
one ion.
When both ions have a valence of one (e.g. NaC1), one millimole (the molecular weight
(MW) of the compound in milligrams) of he compound contains one mEq of each ion.)
If one or both of the ions in the pair has a valence of two or more (e.g. CaC12), one
millimole of the compound contains two or more mEq's of each ion. Two examples are
given below to illustrate. It should be notes that calculations with milliequivalents can be
complex. What is presented here is a simplified version. For a more complete explanation,
consult a book of chemistry or pharmacy.
Example 1
A prescription order calls for Potassium Chloride (KC1) 20 mEq. Calculate the number of
milligrams of Potassium Chloride, which will give this amount.
The atomic weight (AW) of K+ = 39 and the AW of C1 = 35.5. The molecular weight of
(MW) of KC1 = 74.5 mg
Since both ions have a valence of one, 74.5 mg KC1 (the weight of one millimole contains 1
mEq of K and 1 mEq of C1.
Therefore, 20 mEq of KC1 is 20 x 74.5 mg = 1490 mg.
Example 2
A medication order calls for Calcium Chloride (CaCl2) 4 mEq. Calculate the number of
milligrams of Calcium Chloride, which will give this amount.
AW of Ca +2 = 40 and the AW of CI = 35.5
MW of CaCl2 = 40 + 35.5 +35.5 = 11mg
Since Ca+2 has a valence of two, 111mg of CaCl2 (the weight of one millimole) contain
2mEq of Ca+2 and 2 mEq of Cl.
Therefore, 4 mEq of CaCl2 is 2 x 111 mg = 222 mg
Millimoles
Used in pharmacy and medicine to express the dose for certain ions which can have different
valences depending on the conditions
Phosphate is one example of such an electrolyte
A millimole of a compound is the molecular weight of the compound in milligrams
Expressions of Concentration
Concentration gives the quantity of drug per amount (weight or volume) of product.
Always used for expressing doses for topical preparations because concentration is the
driving force for transfer of the drug across a membrane or barrier, such as the skin.
May be used for some systemic products
In reality, since a pure drug is almost never dispensed, quantities, when used in reference to
a product, are technically concentrations
e.g. Acetaminophen 500mg weighs more than 500mg. The active ingredient
(Acetaminophen) weighs 500mg.
Ratio Strength
1 gram (for solids) or 1 ml (for liquids) per given weight or volume of product
As with percents, ratio strength can be weight I weight (solids in solids), weight in volume
(solids in liquids), or volume in volume (liquids in liquids).
Example: Weight in Volume Potassium Permanganate Solution 1:5000 is 1 g of Potassium
Permanganate in 5000 ml of solution
Example 2
The technician is asked to make 4 oz of a 50% solution of Isopropyl Alcohol (IPA)
Ingredients available: Isopropyl Alcohol 70% and water
How many milliliters of each will you need?
Then calculate the number of milliliters of 70% IPA required to give this amount of pure
IPA:
Measure 86 ml of 70% OPA and add sufficient Purified Water to give 120 ml of solution.
Measure 86 ml of 70% Isopropyl Alcohol and add sufficient Purified Water to give 120 ml
of solution
Solve By Alligation:
Alligation Worksheet, Step 1 - Ex. 2 ( 02070090 )
Example 1
You have 5 ml of Gentamicin Ophthalmic Solution 0.3%. You dilute it with 2 ml of sterile
normal saline. What is the percent of Gentamicin in the final solution?
Calculate the amount of drug in the original solution(s) from the concentration and volume
Example 2
You have an IM injection of Rocephin 2 Gm per 10 ml vial. You put 1 ml in an empty vial
and dilute with 3.3 ml of Lidocaine HCI 2% for injection. What is the final concentration
of Rocephin in mg/ml?
2 Gm = 2000 mg
Equation - Ex. 2 ( 02070400 )
What is the final concentration of Lidocaine HCI in percent?
2% = 2 gm/100 ml
Equation - Ex. 2 ( 02070500 )