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Synapsetypes PDF
Synapsetypes PDF
Delay of about 1 ms
Physiology of Electrical Synapses:
A. Experimental set-up:
Current passing
electrode
I presynaptic cell
0.3 msec or less between
pre- and postsynaptic action
potentials
Vm presynaptic cell
Thus, very short
synaptic delay
Vm postsynaptic cell
Physiology of Electrical Synapses: (cont’d)
I presynaptic cell
0.3 msec or less between pre- and postsynaptic
membrane depolarizations
Vm presynaptic cell
Thus,
1) very short synaptic delay and
little decrement of original signal,
I presynaptic cell
0.3 msec or less between membrane
depolarizations
Vm presynaptic cell
1.Thus, bidirectional synaptic
Change in Vm transmission exists.
slightly less than
postsynaptic cell 2. Together with short synaptic delay
Vm postsynaptic cell and small decrement in signal the
results suggest that signal
transmission is via electrotonic
current transmission.
Physiology of Electrical Synapses: (cont’d)
Vm postsynaptic cell
Physiology of Chemical Synapses:
A. Experimental set-up:
axon
Current passing
electrode
Vm presynaptic cell
Thus, synaptic delay is
significantly longer than
for an electrical
synapse.
Vm postsynaptic cell
Physiology of Chemical Synapses: (cont’d)
I presynaptic cell
Vm postsynaptic cell
Physiology of Chemical Synapses: (cont’d)
I presynaptic cell
No signal
transmission Thus, signal transmission is
unidirectional. Together with
Vm presynaptic cell other experimental results, this
result suggests that signal
transmission is not via
AP electrotonic current transmission
and that it requires a presynaptic
Vm postsynaptic cell AP.
Physiology of Chemical Synapses: (cont’d) What
Current is Required for Signal Transmission
E. Experiment #4: inject threshold current in presynaptic cell bathed
in tetrodotoxin to block Na+ current
0.3-5 msec delay between pre-
I presynaptic cell and postsynaptic action
potentials
Vm presynaptic cell
Thus, the Na+ current is
not required for
chemical synaptic
transmission.
Vm postsynaptic cell
Physiology of Chemical Synapses: (cont’d) What
Current is Required for Signal Transmission
F. Experiment #5: inject threshold current in presynaptic cell bathed
in tetraethylammonium ion to block K+ current
0.3-5 msec delay between pre-
I presynaptic cell and postsynaptic action
potentials
Vm presynaptic cell
Thus, the K+ current is
not required for
chemical synaptic
transmission.
Vm postsynaptic cell
Physiology of Chemical Synapses: (cont’d) What
Current is Required for Signal Transmission
G. Experiment #6: inject threshold current in presynaptic cell bathed
in Ca2+-free medium
I presynaptic cell
Vm presynaptic cell
Thus, the Ca+ current is
required for chemical
synaptic transmission.
Vm postsynaptic cell
No postsynaptic
response
The Calcium Dependent Model of
Neurotransmitter Release:
AP
Vm
Majority of
(mVolts)
synaptic delay
ICa2+
(uamps)
Time (msec)
The Calcium Dependent Model of
Neurotransmitter Release: (cont’d)
Voltage-gated
calcium channels
Calcium influx is sufficient for neurotransmitter release