Professional Documents
Culture Documents
Critically Appraising
the Evidence:
Statistics for Therapy
Table of Contents
• Clinical Statistics Calculator (Excel)
• Statistics for:
– Therapy
• Control Event Rate (CER) & Experimental Event Rate (EER)
• Number Needed to Treat (NNT)
– Absolute Risk Reduction (ARR)
• Relative Risk (RR)
• Odds
• Odds Ratio (OR)
• Practice Exercises
Making It Easier
•If available, find the best evidence in
secondary sources where analysis has
already occurred.
•If not pre-assessed, use critical
appraisal worksheets to help you
through the process.
Importance of Critically
Appraising the Evidence
• Understanding the Limitations of the
Author’s Analyses and Interpretations of
the Data
• Assessing Internal Validity
• Assessing External Validity
• Identifying Potential Confounding Variables
– Simpson’s Paradox
Critical Appraisal Basics
• View movie as:
– QuickTime
(.mov)
– Flash (.swf)
• RR = EER / CER
= (a/(a+b)) / (c/(c+d))
Relative Risk Video
• View movie as:
– QuickTime
(.mov)
– Flash (.swf)
• A measure of association
• When large, there is greater association
Try it on your own.