Human Papilloma Virus (HPV) is one of the causative agents of cervical
cancer. It is the second most lethal cancer in women, second only to breast cancer, killing 275,000 women worldwide every year. Human papilloma virus vaccines are vaccines that prevent infection by certain types of human papillomavirus. Available vaccines protect against either two, four or nine types of HPV. All vaccines protect against at least HPV types 16 and 18, which cause the greatest risk of cervical cancer. A successful HPV vaccination is considered a major medical accomplishment. The U.S. Food and Drug Administration (FDA) has approved HPV vaccines like Gardasil and Cervarix for use among females between 9 – 26 years of age. The first HPV vaccine became available in 2006. As of 2017, 71 countries include it in their routine vaccinations, at least for girls. They are on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$47 a dose as of 2014. In the United States, it costs more than US$200. Vaccination may be cost effective in the developing world. Discovered by: Ian Frazer and Jian Zhou at the University of Queensland in 2006