name:

partner’s name:
hemoglobin dissociation curves

20
active
muscle

20
active
muscle

1. What is the O2 saturation of Hb when PO2 = 100 mm Hg? Where/when does this
occur?

2. What is the O2 saturation of Hb when PO2 = 40 mm Hg? Where/when does this occur?

3. What is the O2 saturation of Hb when PO2 = 20 mm Hg? Where/when does this occur?
4. Describe the cooperatively between the hemoglobin subunits

5. Explain how the cooperatively between the hemoglobin subunits influence the shape of
the dissociation curve?
6. In general, how does the decreased pH shift the dissociation curve?

7. When would there be a higher concentration of CO2 in the blood?

8. What effect does increased blood CO2 have on blood pH?

9. Explain why your answers in #6-8 make sense in terms of body function
A. Summarize the overall data trends shown for dissociation of fetal vs. adult hemoglobin.

B. When is fetal vs. adult hemoglobin 50% saturated?

C. Propose a physiological reason for the differences described in parts A and B