Maternal medicine

Objective The authors evaluated the differences in twin pre-

term birth rates in the setting of pre-eclampsia by gestational
age at birth and between different racial/ethnic groups.
Study Design This is a retrospective cohort study of women
pregnant with twins delivered in California in 2006, sepa-
rated into two cohorts: pre-eclampsia and no pre-eclampsia.
Outcome data were tabulated by four gestational age groups
(24–27, 28–31, 32–36 and 37–42 weeks) and stratified by race/
ethnicity.
Results Women with pre-eclampsia are at a significantly
increased risk of delivering at 32–36 weeks as compared to
women without pre-eclampsia (p<0.001): 61.4% vs 45.5%.
Preterm delivery rates in the setting of pre-eclampsia varied
by race/ethnicity and were significantly higher in Caucasians
and lower in Asians (p<0.001): 71.0% in Caucasians, 66.7% in
African Americans, 67.0% in Latinas and 63.6% in Asians.
Conclusion Women with twins who also have pre-eclampsia
have 15.9% more preterm births. Although African American
women without pre-eclampsia experience higher preterm
birth rates than other racial/ethnic groups, this effect is not
seen in African American women with pre-eclampsia. In the
setting of pre-eclampsia, Caucasians have more and Asians
have fewer preterm births than other racial/ethnic groups.

PM.50 PRE-ECLAMPSIA AS AN ETIOLOGY FOR PRETERM

BIRTH: WHAT IS THE BURDEN OF DISEASE FOR
TWINS?
SA Vogel1, AJ Kane1, R Rajaii2, Y Cheng1, AB Caughey1 1University of California, San
Francisco, USA; 2University of California, Berkeley, USA

10.1136/adc.2010.189753.50

Fa48 Arch Dis Child Fetal Neonatal Ed 2010;95(Suppl X):Fa33–Fa62