CLINICAL KEY

No Title
1 Effectiveness of fixed dose combination medication (‘polypills’) compared with usual care in patients with

2 Prevention of stroke: a global perspective

3 A Polypill Strategy to Improve Global Secondary Cardiovascular Prevention

4 Can a polypill one single tablet combat different cardiovascular risk factors?

5 Polypills
6 Long-Term Use of Cardiovascular Drugs

7 Putting polypills into practice: challenges and lessons learned

8 Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention

9 Future of Polypill Use for the Prevention of Cardiovascular Disease and Strokes

10 Modeling the cost effectiveness and budgetary impact of Polypills for secondary prevention of cardiovascu

11 Polypill-Based Therapy: A Promising Therapeutic Strategy

12 Primary Prevention of Cardiovascular Disease in Minority Indigenous Populations: A Systematic Review

13 Long-Term Outcomes of Stroke in a Ghanaian Outpatient Clinic

14 Acceptance of a Polypill Approach to Prevent Cardiovascular Disease Among a Sample of U.S. Physicians

15 Cost-effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular disease

16 Physician support for a population-based pharmaceutical approach to cardiovascular prevention: Not there

17 Polypill: Chimera or Reality?

18 Toward a Modern Delivery of Stroke Care in Emerging Economies

19 Polypill Therapy, Subclinical Atherosclerosis, and Cardiovascular Events—Implications for the Use of Pre

20 Promoting Cardiovascular Health Worldwide: Strategies, Challenges, and Opportunities

21 Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevati

22 Improving adherence using combination therapy (IMPACT): Design and protocol of a randomised controll

23 Ensuring Patient-Centered Access to Cardiovascular Disease Medicines in Low-Income and Middle-Incom

24 Uses of polypills for cardiovascular disease and evidence to date

25 Interventions for Cardiovascular Disease Prevention

26 Clinical Effectiveness of the Cardiovascular Polypill in a Real-Life Setting in Patients with Cardiovascular

27 Modernizing the World Health Organization List of Essential Medicines for Preventing and Controlling Ca

28 Polypill Opens a Path for Improving Adherence

29 Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (T

30 Salim Yusuf: global leader in cardiovascular disease research

31 Adherence to Medical Therapy and the Global Burden of Cardiovascular Disease

32 A Polypill Strategy to Improve Adherence

33 Polypill: Can its Potential Enhancement of Efficacy Trigger New Interest?

34 Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America

35 Prevention of cardiovascular disease with a polypill

36 Applying Precision Medicine to Healthy Living for the Prevention and Treatment of Cardiovascular Diseas

37 Dying with cardiovascular disease, not of it

38 Interpretation of the evidence for the efficacy and safety of statin therapy

39 Polypill, hypertension and medication adherence: The solution strategy?

40 Impact of switching to polypill based therapy by baseline potency of medication: Post-hoc analysis of the S

41 The Polypill in the prevention of cardiovascular disease

42 A Polypill Intervention To Improve Adherence For Secondary
43 Prevention of cardiovascular disease
44 A Randomized, Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and the Toler
45 Efficacy and Safety of Triple Therapy With Telmisartan, Amlo
46 Projected impact of polypill use among US adults: Medication u
47 Efficacy and Safety of Fixed-dose Combination Therapy With Telmisartan and Rosuvastatin in Korean Pat
48 Usefulness of a Cardiovascular Polypill in the Treatment of Secondary Prevention Patients in Spain: A Cos
49 Comparison of a morning polypill, evening polypill and individ
50 A Global Perspective on Cardiovascular Disease in Vulnerable Populations

51 The Burden of Cardiovascular Disease in Low- and Middle-Income Countries: Epidemiology and Managem

52 Effects of captopril, spironolactone, and simvastatin on the ca

53 Exploring the Barriers to and Facilitators of Using Evidence-Based Drugs in the Secondary Prevention of C

54 Novel Approaches in Primary Cardiovascular Disease Preventio

55 Novel Pathogenic Insights in the Primary Prevention of Cardio

56 PW203 Impact of pill burden on the effects of a polypill-based

57 The combined use of aspirin, a statin, and blood pressure–lowe
58 A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disea

59 The heart and vascular system in dialysis

60 A Step Ahead in Secondary Prevention of Cardiovascular Risk. Consensus Document on Clinical Use of th

61 Evolution of the Polypill Concept and Ongoing Clinical Trials

62 The International Polycap Study-3 (TIPS-3): Design, baseline c

63 Aspirin underuse, non-compliance or cessation: Definition, extent, impact and potential solutions in the pri

64 Simplifying the medical prevention of cardiovascular disease

65 Increasing Appreciation for the Role of Single-Pill Combinations for the Prevention of Atherosclerotic Dis

66 Polypill and Global Cardiovascular Health Strategies

67 Improving Medication Adherence in Cardiometabolic Disease

68 Pharmacoeconomic Grounding Of Using Polypill Amlodipine With Atorvastatin Versus Monodrugs In Pati

69 Cost-effectiveness of Interventions to Prevent Cardiovascular Disease in Australia's Indigenous Population

70 The impact of dosing frequency on medication adherence in chronic cardiovascular disease: Systematic rev

71 Utilization of and Adherence to Guideline-Recommended Lipid-Lowering Therapy After Acute Coronary S

72 “De-Risking” Risk Reduction

73 Do polyunsaturated fatty acids behave like an endogenous “polypill”
74 O161 Using DCE to assess adherence and treatment preferences for combination therapies for cardiovascu

75 Cardiac Rehabilitation Delivery Model for Low-Resource Settings: An International Council of Cardiovasc

76 CSI position statement on management of heart failure in India

77 Reducing Premature Cardiovascular Morbidity and Mortality in People With Atherosclerotic Vascular Dise

78 Antiplatelet Therapy in Coronary Heart Disease Prevention

79 Diabetes and complications of the heart in Sub-Saharan Africa: An urgent need for improved awareness, di

80 The Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS)

81 Primary Prevention of Atherosclerosis

82 A Proposal to Incorporate Trial Data Into a Hybrid ACC/AHA Algorithm for the Allocation of Statin Thera

83 Cardiovascular Health in Low- and Middle-Income Countries

84 Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal

85 Revista Española de Cardiología: Current Situation and New Projects

86 Highlights of the 2008 Scientific Sessions of the Heart Failure Society of America

87 Statins for All?

88 Never too old for statin treatment?

89 The Year in Atherothrombosis

90 Conceptualizing multiple drug use in patients with comorbidity and multimorbidity: proposal for standard d
91 Deciphering the Causes of Cardiovascular and Other Complex Diseases in Populations: Achievements, Ch

92 The Fixed-dose Combination Drug for Secondary Cardiovascular Prevention project: Improving equitable

93 Are evidence-based cardiovascular prevention therapies being used? A review of aspirin and statin therapie

94 Cost-Effectiveness of a Comprehensive Approach for Hypertension Control in Low-Income Settings in Arg

95 Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individ

96 Assessing the Impact of Medication Adherence on Long-Term Cardiovascular Outcomes

97 Dyslipidaemia among African adults

98 Cost-Effectiveness of Treatment and Secondary Prevention of Acute Myocardial Infarction in India

99 Problems of Nonadherence in Cardiology and Proposals to Improve Outcomes

100 Number of drugs used in secondary cardiovascular prevention and late survival in the population of Valenc

101 Effects of long-term use of cardiovascular drugs

102 Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis

103 Effect of Use of Combination Evidence-Based Medical Therapy After Acute Coronary Syndromes on Long

104 Availability and utilization of cardiovascular fixed-dose combination drugs in the United States

105 Adherence to Cardiovascular Medications: Lessons Learned and Future Direct ions

106 Aiming at Strategies for a Complex Problem of Medical Nonadherence

107 The Indian Polycap Study (TIPS)

108 Multidimensional analysis of treatment adherence in patients with multiple chronic conditions. A cross-sec

109 Cost-Effectiveness of A Polypill for Patients with or at High Risk of Cardiovascular Disease in an NHS Se

110 PCV93 the Polypill in the Primary Prevention of Cardiovascular Disease: Cost-Effectiveness in the Dutch

111 The World Heart Federation's vision for worldwide cardiovascular disease prevention

112 Can the polypill save the world from heart disease?

113 Selection of the Best of 2016 in Clinical Cardiology: Continuum of Care; Relationship Between Cardiolog

114 Long-term antiplatelet therapy with the polypill after stenting: More information is necessary

115 Precision Medicine, Healthy Living and the Complex Patient: Managing the Patient With Multimorbidity

116 Usefulness of PA32540 in Protecting the Gastric Layer While Providing Secondary Prevention for Coronar

117 Exercise as the master polypill of the 21st century for the prevention of cardiovascular disease
118 Real-life use of the polypill components (ASA + ACEI + statins) after an acute coronary syndrome and lon

119 PM082 Interventions to Improve Medication Adherence in Coronary Disease Patients: A Systematic Revie

120 The future of preventive medicine: Polypill prescriptions in the context of Plato's physical perspective

121 Modern Challenges in Treating Hypertension

122 Selection of the Best of 2016 in Clinical Cardiology: Therapeutic Novelties

123 Implementation of a Nationwide Strategy for the Prevention, Treatment, and Rehabilitation of Cardiovascu

124 Polypills for high risk patients: Results of a New Zealand randomised controlled trial

125 Reducing Acute Coronary Events: The Solution Is Not So Difficult!

126 Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-inc

127 Long-term Cardiovascular Risk After Acute Coronary Syndrome, An Ongoing Challenge

128 Underuse of Effective Cardiac Medications Among Women, Middle-Aged Adults, and Racial/Ethnic Mino

129 Is there a role for coronary artery calcification scoring in primary prevention of cerebrovascular disease?
130 Surgical Revascularization versus Percutaneous Coronary Intervention and Optimal Medical Therapy in Di

131 Vascular endo thelium summary statement II: Cardiovascular disease prevention and control

132 Strengthening Preventive Cardiology

133 Comparison of cardiovascular risk assessment tools and their guidelines in evaluation of 10-year CVD risk

134 Effect of Renin-Angiotensin System Inhibitors on Long-Term Survival in Patients Treated With Beta Block

135 TRIple pill vs Usual care Management for Patients with mild-to-moderate Hypertension (TRIUMPH): Stud

136 Calculating additive treatment effects from multiple randomized trials provides useful estimates of combin

137 Comparison of in-hospital secondary prevention for different vascular diseases

138 Cost-effectiveness Considerations of Cardiovascular Therapeutics

ICAL KEY

Journal Year
International Journal of Cardiology. 2015

Lancet, The. 2018

JACC (Journal of the American College of Cardiology).

2014

Journal of the American Society of Hypertension.

2018

JACC (Journal of the American College of Cardiology).

2014
JACC (Journal of the American College of Cardiology).
2015

Lancet, The. 2017

Atherosclerosis. 2017

American Journal of Cardiology, The. 2014

American Heart Journal. 2019

Heart, Lung and Circulation. 2017

Heart, Lung and Circulation. 2019

Journal of Stroke and Cerebrovascular Diseases.2018

Preventive Medicine. 2010

International Journal of Cardiology. 2018

Preventive Medicine. 2010

Spanish Journal of Cardiology (Revista Española

2014
de Cardiología, English Edition).
Journal of Stroke and Cerebrovascular Diseases.2013

JACC (Journal of the American College of Cardiology).

2014

Spanish Journal of Cardiology (Revista Española

2014
de Cardiología, English Edition).

Journal of Clinical Lipidology. 2017

Contemporary Clinical Trials. 2011

Cardiology Clinics. 2016

Lancet, The. 2017

Cardiology Clinics. 2011

Archives of Medical Research. 2019

JACC (Journal of the American College of Cardiology).

2018

JACC (Journal of the American College of Cardiology).

2014

Lancet, The. 2009

Lancet, The. 2015

JACC (Journal of the American College of Cardiology).
2016

JACC (Journal of the American College of Cardiology).

2014

Global Heart (formerly CVD Prevention and Control).

2016

Global Heart (formerly CVD Prevention and Control).

2019

Lancet, The. 2007

Current Problems in Cardiology. 2018

Trends in Cardiovascular Medicine. 2015

Lancet, The. 2016

International Journal of Cardiology. 2017

International Journal of Cardiology. 2017

Preventive Medicine. 2010

Value in Health. 2015
Trends in Cardiovascular Medicine. 2015
Clinical Therapeutics. 2017
Clinical Therapeutics. 2018
American Heart Journal. 2011
Clinical Therapeutics. 2018
Spanish Journal of Cardiology (Revista Español2017
International Journal of Cardiology. 2014
Cardiology Clinics. 2016

Canadian Journal of Cardiology. 2015

International Journal of Cardiology. 2015

Global Heart (formerly CVD Prevention and Co2017

Canadian Journal of Cardiology. 2016

Progress in Cardiovascular Diseases. 2009

Global Heart (formerly CVD Prevention and Control).2014

American Heart Journal. 2013
Journal of Clinical Lipidology. 2015

Lancet, The. 2016

Spanish Journal of Cardiology (Revista Española

2016
de Cardiología, English Edition).

Canadian Journal of Cardiology. 2014

American Heart Journal. 2018

International Journal of Cardiology. 2014

medicine 2014

Canadian Journal of Cardiology. 2014

Seminars in Thoracic and Cardiovascular Surgery.

2011

JACC (Journal of the American College of Card2017

Value in Health. 2014

Heart, Lung and Circulation. 2013

Portuguese Journal of Cardiology. 2014

JACC (Journal of the American College of Card2015

JACC (Journal of the American College of Card2014

Medical Hypotheses. 2007
Global Heart (formerly CVD Prevention and Control).
2014

Progress in Cardiovascular Diseases. 2016

Indian Heart Journal. 2018

Global Heart (formerly CVD Prevention and Co2015

Cardiology Clinics. 2011

Diabetes Research and Clinical Practice. 2018

JACC (Journal of the American College of Card2012

JACC (Journal of the American College of Card2017

JACC (Journal of the American College of Card2015

Current Problems in Cardiology. 2014

Diabetes & Metabolism. 2014

Spanish Journal of Cardiology (Revista Español2018

JACC (Journal of the American College of Card2009

American Journal of Cardiology, The. 2014

Lancet, The. 2019

JACC (Journal of the American College of Card2012

Journal of Clinical Epidemiology. 2018
Progress in Cardiovascular Diseases. 2010

American Heart Journal. 2011

Prevention and Control. 2006

Value in Health. 2018

International Journal of Cardiology. 2013

JACC (Journal of the American College of Card2016

lancet global health 2018

Global Heart (formerly CVD Prevention and Control).

2014

American Journal of Cardiology, The. 2010

International Journal of Cardiology. 2019

Lancet, The. 2015

American Journal of Medicine, The.

American Journal of Cardiology, The. 2012

American Heart Journal. 2015

Progress in Cardiovascular Diseases. 2013

Global Heart (formerly CVD Prevention and Control).

2013

Lancet, The. 2009

Patient Education and Counseling. 2010

Value in Health. 2017

Value in Health. 2011

Lancet, The. 2015

Lancet, The. 2009

Spanish Journal of Cardiology (Revista Española

2016
de Cardiología, English Edition).

International Journal of Cardiology. 2016

Progress in Cardiovascular Diseases. 2019

American Journal of Cardiology, The. 2017

International Journal of Cardiology. 2014

International Journal of Cardiology. 2014

Global Heart (formerly CVD Prevention and Control).

2016

Preventive Medicine. 2012

Clinical Therapeutics. 2016

Spanish Journal of Cardiology (Revista Española

2016
de Cardiología, English Edition).

Archives of Medical Research. 2018

Heart, Lung and Circulation. 2014

American Journal of Medicine, The. 2015

Lancet, The. 2011

Spanish Journal of Cardiology (Revista Española

2015
de Cardiología, English Edition).

American Journal of Cardiology, The. 2017

Atherosclerosis. 2017
Progress in Cardiovascular Diseases. 2015

Vascular Pharmacology. 2007

Heart, Lung and Circulation. 2015

International Journal of Cardiology. 2016

American Journal of Cardiology, The. 2014

American Heart Journal. 2014

Journal of Clinical Epidemiology. 2012

European Journal of Internal Medicine. 2009

Heart, Lung and Circulation. 2008

 WILEY ONLINE LIBRARY
No Title Journal
1 Implementation of a simple age‐based strategy in the prevention
Journal of
ofEvaluation
cardiovascular
in Clinical
disease:Practice
the Polypill approa

2 The polypill in the primary prevention of cardiovascularFundamental

disease & Clinical Pharmacology

3 The Effect of a Cardiovascular Polypill Strategy on Pill Burden

Cardiovascular Therapeutics

4 Maximizing Therapeutic Envelope for Prevention of Cardiovascular

Mount Sinai Disease:
Journal of
Role
Medicine:
of Polypill
A Journal of Transla

5 Novel Treatments for Cardiovascular Disease PreventionCardiovascular Therapeutics

6 Opinions of community pharmacists on the value of a cardiovascular

International Journal
polypill of
as Pharmacy
a means ofPractice
improving medica

7 Combination Polypharmacy for Cardiovascular Disease Preventive

Prevention Cardiology
in Men: A Decision Analysis and Cost‐Effe

8 Fixed‐dose combination therapy to reduce the growing burden

The Journal
of cardiovascular
of Clinical Hypertension
disease in low‐ and middle‐in

9 The Polypill Progress in Cardiovascular Nursing

10 Comparative Cost‐Effectiveness of Interventions to Improve
Health
Medication
Services Researc
Adherence after Myocardial Infarctio
11 An economic case for a cardiovascular polypill? A cost analysis
MedicalofJournal
the Kanyini
of Australia
GAP trial

12 CAN MEASUREMENT OF B‐TYPE NATRIURETIC PEPTIDE

Clinical and
LEVELS
Experimental
IMPROVEPharmacology
CARDIOVASCULAR
and Physiolo

13 A pilot double‐blind randomised placebo‐controlled trialInternational

of the effectsJournal
of fixedof‐dose
Clinical
combination
Practice therapy (‘pol

14 The challenge of polypharmacy in cardiovascular medicine

Fundamental & Clinical Pharmacology

15 ‘Multiple action fixed combination. Present or future?’ Fundamental & Clinical Pharmacology

16 Treatment of Modifiable Risk Factors Is Associated WithThe

Decrease
JournalinofCoronary
Clinical Hypertension
Heart Disease Incidence: Time

17 Predictors of Long‐term Adherence to Evidence‐based Cardiovascular

Clinical Cardiology
Disease Medications in Outpatients Wit

18 From Treating Complex Coronary Artery Disease to Promoting

ClinicalCardiovascular
Pharmacology Health:
& Therapeutics
Therapeutic Transition
19 Treatment of Dyslipidemia and Cardiovascular Outcomes:
Clinical
The Journey
Pharmacology
So Far—Is
& Therapeutics
This the End for Statins?

20 Optimal pharmacological treatment and adherence to medication

Cardiovascular
in secondary
Therapeutics
prevention of cardiovascular ev

21 The American Society for Preventive Cardiology: Our 30Clinical

‐year legacy
Cardiology

22 Polypharmacy in Older Adults With Hypertension: A Comprehensive

The Journal ofReview
Clinical Hypertension

23 The Poly‐pill: does it work and is chronic therapy acceptable?

International Journal of Clinical Practice

24 Design of a Dissolving Microneedle Platform for Transdermal

JournalDelivery
of Pharmaceutical
of a Fixed‐Sciences
Dose Combination of Cardi

25 Evaluating the costs and benefits of using combination therapies

Medical Journal of Australia
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2011

2011

2008

2018

2009
2012
2014

2008

2010

2010

2010

2016

2013

2011
2014

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2016

2015

2010

2015

2014