F O R M U L A T I O N S

ABH Sugar Troche (24 Troches)

Rx
Lorazepam 24 mg
Diphenhydramine HCl 600 mg
Haloperidol 96 mg
Acacia 1.65 g
Powdered sugar 21.63 g
Purified water qs
Flavor qs

METHOD OF PREPARATION
1. Weigh/ measure the ingredients.
2. Mix the lorazepam, diphenhydramine HCl and haloperidol
powders together.
3. Mix the acacia and sufficient purified water together in a mortar to
form a mucilage.
4. Sift the powdered sugar and the drug powders from Step 2 together.
5. Gradually add sufficient mucilage, from Step 3, to the powders to
make a mass of the proper consistency to roll. (Incorporate flavor
if desired at this point).
6. Roll the mass into the shape of a cylinder and cut into 24 even
sections. PACKAGING Packaging depends upon the mold that is used. Some
7. Allow to air dry. molds are the dispensing package. For others, the troches can be
8. Package and label. placed in a suitable container or even a plastic baggie.

USE The troches can be used for hospice patients or patients on LABELING Store in a cool place. Keep out of reach of children.
chemotherapy who experience severe nausea. The formula can be STABILITY No stability studies have been reported on this
modified and can be appropriate for both geriatric and pediatric specific formulation.
patients.

ABH Soft Troche (24 Troches)

METHOD OF PREPARATION
Note: It is necessary to calibrate the troche mold using the polyethylene
glycol 1450 base prior to determining the exact quantity of polyethyl- Rx
ene glycol 1450 required for this prescription. Lorazepam 24 mg
1. Weigh/measure the ingredients. Diphenhydramine HCl 600 mg
2. Mix the lorazepam, diphenhydramine HCl and haloperidol Haloperidol 96 mg
powders together.
NutraSweet® 480 mg
3. Add the NutraSweet®, silica gel and acacia powder and mix.
Silica gel 240 mg
4. Melt the polyethylene glycol 1450 at a temperature of about 55°
Acacia powder 400 mg
to 60°C.
Cinnamon oil 3 drops
5. Sprinkle the powder on the melt with thorough mixing.
Polyethylene glycol 1450 21 g (depending upon mold
6. Remove from heat for a few minutes, then add the cinnamon
used)
oil (or other suitable flavor) and mix.
7. Pour into molds (at room temperature) and allow to cool at room
Some molds are the dispensing package. For others, the troches can
temperature.
be placed in a suitable container or even a plastic baggie.
8. Package and label.
LABELING Store in a cool place. Keep out of reach of children.
USE The troches can be used for hospice patients or patients on
chemotherapy who experience severe nausea. The formula can be STABILITY No stability studies have been reported on this spe-
modified and can be appropriate for both geriatric and pediatric cific formulation.
patients. NutraSweet® is a registered trademark of The NutraSweet Company,
Deerfield, IL.
PACKAGING Packaging depends upon the mold that is used.

International Journal of Pharmaceutical Compounding 27

Vol. 1 No. 1 Jan/Feb 1997