Name: Date of Activity:

Yr./section: Score:

Learning Activity No. 14

PARACETAMOL TABLET

OBJECTIVES

At the end of the topic, the students are expected to:

 Formulate paracetamol tablet 500 milligrams;

 Discuss the uses and roles of each ingredient used in the formulation.

 Identify the process used in the production of paracetamol 500mg tablet.

 Compare the results of quality control test of the product to the standard
specification of paracetamol 500mg tablet.

Learning Resources:

Oven Measuring apparatus

Tabletting machine with 500mg punch and die Blender
Sieve Chemicals based on the procedure
Analytical balance/top loading
Spatula

Learning Strategies

Paracetamol tablets belong to a group of medicines called analgesics. They are

used for relief of mild to moderate pain and feverish conditions such as headache,
toothache, colds, influenza, joint pain and period pains.
Learning Content:

PRODUCT: PARACETAMOL BRAND NAME:

TABLET
BATCH SIZE: 500 TABLETS (500MG) STRENGTH:
BATCH NUMBER: DATE STARTED:
EXPIRY DATE: DATE FINISHED:

FORMULA AND WEIGHING RECORD

CODE MATERIAL AMOUNT Reduced DISPENSED CHECKED

in Amount BY BY
100,000ta
b
Paracetamol 50kg
powder
Starch 6kg
Methyl Paraben 0.11kg
Sodium
Propyl Paraben 0.20kg
Gelatin (in 30kg
solution)
LUBRICANTS
Talcum 6kg
Magnesium 6kg
stearate

MAJOR EQUIPTMENT

 Hot Plate

 Analytical Balance

 Mixing Tank
  Miller

Manufacturing Instructions and Record

Name of Operator: _________________Signature: ______ Name of Checker: _____________Signature: ____

DATE TIME OPERATOR CHECKER

1. Weigh all ingredients.
2. Mix all the dry ingredients
first, followed by liquid
ingredients.
3. Granulate to form a damp
mass.
4. Screen the damp mass
using sieve# 20
5. Dry at the oven
(120degree F)
6. Dry screen using sieve #
50 or 60
7. Add the lubricant
ingredients
8. Compress tablet using the
tableting machine.
9. Weigh all the tablet
produce.
10. Perform quality control
tests of the tablet.

MANUFACTURING SPECIFICATIONS:

Tests Standard Specification Result/Observation

Moisture content 10%
Total weight of granules 60kg
Weigh per tablet 500mg
Thickness
Friability NMT 1%
Punch size 12.5nm
Hardness 4-10kg
Digsintegration time 30 minutes
(Use Simulated Gastric
 Fluid)

Student Learning Evaluation:

1. Give the synonym and uses of the following ingredient.

Ingredient Synonym Role/Use in the Ointment

formulation

Paracetamol

Starch

Silicon dioxide
(Aerosil)

Methyl Paraben
Sodium

Propyl Paraben
Sodium

Gelatin

Alcohol

Talcum

Magnesium
stearate

2. Give the description and application in pharmaceutical formulation of the

following ingredients:

Ingredient Description (at least 5) Application in

Pharmaceutical Formulation
(at least 3)

Paracetamol
Starch

Silicon dioxide
(Aerosil)

Methyl Paraben
Sodium

Propyl Paraben
Sodium

Gelatin

Alcohol

Talcum

Magnesium
stearate
  Enumerate the equipment’s used for the manufacture of tablets. Discuss the
principle on the use of each equipments.

Learning Activity No. 15

TOOTHPASTE

11. Weigh and measure the

ingredients correctly and
label.
12. Mix the precipitated
calcium carbonate and
hard soap into fine powder,
using the mortar and
pestle.
13. Mix alcohol and glycerin in
a separate beaker.
14. Add slowly and with
constant trituration the
alcohol-glycerin mixture to
the powder mixture until a
paste of proper
consistency is formed.
15. Lastly add the flavor and
incorporate it thoroughly.
16. Transfer immediately the
product to desired
container.

Learning Activity No. 16

SHAMPOO
17. Weigh and measure the
ingredients correctly and
label.
18. Dissolve Sodium lauryl
sulfate and Sodium
chloride in 40 ml of warm
purified water.
19. Add the
monoethanolamine while
mixing slowly.
20. Incorporate the propylene
glycol and your desired
extract while continuously
 mixing gently.
21. Add the desired scent.
22. Transfer immediately the
product to desired
container.
Learning Activity No. 17

Deodorant Cream

23. Weigh and measure the

ingredients correctly and
label.
24. Dissolve Aluminum Sulfate
in water and filter the
solutuion.
25. Melt the white petrolatum,
white wax and cholesterol
at 80 degree C.
26. Stir constantly while the
mixture is congealing.
27. When it has reached about
50 degree C, transfer it
into a mortar and
incorporate the aqueous
solution by trituration.
28. Add the scent the transfer
immediately the product to
desired container.