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cute respiratory failure in chil- ever, it can only be accurately stated that Normal control of breathing is a
dren is the inability of the re- the PaCO2 is no higher than the PvCO2. complex interaction between the vas-
spiratory system to support Therefore, when PvCO2 is <50 mm Hg, culature, brain, lungs, and respiratory
oxygenation, ventilation, or both. Hy- acute hypercarbic respiratory failure can apparatus. Peripheral chemoreceptors,
poxic respiratory failure is defined by be ruled out but a PvCO2 of 55 mm Hg located in the aortic and carotid bod-
an arterial partial pressure of oxygen does not guarantee a diagnosis of hy- ies, are sensitive to PaO2, PaCO2, and
(PaO2) below 60 mm Hg, which typical- percarbic respiratory failure. PvCO2 is pH. A decrease in PaO2, a decrease
ly produces an arterial oxygen saturation a test that has high sensitivity but poor in pH or an increase in CO2 results
of 90%. Ventilation is the elimination specificity for diagnosing hypercarbic in signaling to increase ventilation.
of CO2 and is measured by the arterial respiratory failure. PvCO2 should be in- Central chemoreceptors in the brain
partial pressure of CO2 (PaCO2). Acute terpreted carefully based on location of are sensitive to cerebral spinal fluid
hypercarbic respiratory failure is defined sampling, manner of sampling, and car- (CSF) pH. The blood-brain barrier al-
by an acute increase in PaCO2 greater diac output. lows CO2, but not hydrogen ions, to
than 50 mm Hg. It is typically associated pass freely so the CSF pH is deter-
with a respiratory acidosis pH of <7.35. EPIDEMIOLOGY mined by PaCO2. Therefore, the cen-
Venous blood may be sampled in lieu Acute respiratory failure is a com- tral chemoreceptors can detect small
of arterial blood to obtain the venous mon reason for admission to the pedi- changes in CO2. Input from peripheral
partial pressure of CO2 (PvCO2); how- atric intensive care unit (PICU). The and central chemoreceptors is inte-
grated in the brainstem. The pons and
Matthew L. Friedman, MD, is the Medical Director of Community Hospital North; and an Assistant medulla generate periodic impulses to
Professor of Clinical Pediatrics. Mara E. Nitu, MD, is the Division Chief of Pediatric Critical Care, the Vice trigger breathing. Injury to the brain-
Chair of Clinical Affairs for Pediatrics, and a Professor of Clinical Pediatrics. Both authors are affiliated stem leads to characteristic, abnormal
with the Section of Pediatric Critical Care, Riley Hospital for Children, Indiana University School of respiratory patterns based on the level
Medicine. of injury.3 The cortex can override this
Address correspondence to Matthew L. Friedman, MD, 705 Riley Hospital Drive, Phase 2, Room 4927, automatic mechanism with voluntary
Riley Hospital for Children, Indianapolis, IN 46202; email: friedmml@iu.edu. respiratory effort.
Disclosure: The authors have no relevant financial relationships to disclose. The main muscle of inspiration is
doi:10.3928/19382359-20180625-01
the diaphragm, which is innervated
by the phrenic nerve that originates lation and an acute angle of the right diffuses across the alveolar-capillary
from spinal nerve roots C3 to C5. upper lobe bronchus, predisposing membrane more rapidly than oxygen.
Thus, patients with spinal cord inju- them to atelectasis.4 The chest wall
ries at or above this level are at risk of a child is more compliant, which ETIOLOGY
for diaphragmatic paralysis and respi- from a mechanical standpoint, is dis- Acute respiratory failure has three
ratory failure. Phrenic nerve stimula- advantageous for normal breathing. major etiological categories: intrinsic
tion causes contraction and flattening The diaphragm of children fatigues and acquired lung disease, airway dis-
of the dome-shaped diaphragm. This quicker than adults due to fewer type- orders, and neuromuscular dysfunc-
leads to an increase in intrathoracic 1 muscle fibers. Lastly, in young in- tion (Table 1). Diseases that lead to
volume and consequently a decrease fants, the central control of breathing respiratory failure from pulmonary
in intrathoracic pressure. A negative is immature and prone to apnea and pathology are caused by V/Q mis-
pressure gradient is generated be- bradypnea.5 matching, gas diffusion impairment,
tween the alveoli and the external en- Impairments in oxygenation or ven- or both. Airway disorders more com-
vironment, resulting in net movement tilation leading to respiratory failure monly lead to respiratory failure in
of air to the alveoli. This negative are most often due to ventilation/per- more children than adults due to the
pressure breathing is contrasted to the fusion (V/Q) mismatch. Although the smaller radius of the airway. Neuro-
positive pressure breathing of invasive ideal 1:1 ratio of ventilation to perfu- muscular causes of respiratory failure
mechanical ventilation. sion is rare, in acute lung disease the can occur anywhere from the central
Thoracic spinal nerve roots inner- mismatch becomes more severe. Lung nervous system to the innervated mus-
vate the external intercostal muscles to segments perfused but not ventilated cles of respiration.
aid in inspiration by pulling the chest are considered dead space (V/Q ap-
upward and anteriorly. Exhalation is a proaches infinity). Examples of dead EVALUATION
passive process during quiet breathing space ventilation include anatomical The initial assessment of children
due to the elastic recoil of the lungs dead space (large airways), pulmo- with concern for impending acute re-
and chest wall. When exercising or in nary embolism, and severe pulmonary spiratory failure aims to determine
respiratory distress, exhalation can be hypertension. Clearance of CO2 is im- the degree of respiratory impairment.
an active process assisted by internal paired when dead space is increased, Experienced clinicians can make this
intercostal muscles pulling the rib resulting in hypercarbia. Areas of the determination quickly at the bedside
cage inwards and down, and abdomi- lung that have perfusion but no ven- by astute observation. Assessment of
nal wall musculature contracting and tilation result in shunt physiology patient vital signs, general appear-
forcing abdominal contents upward (V/Q = 0). In shunt physiology, blood ance, lung examination, and mental
into the thoracic cavity and increasing passes from pulmonary artery to pul- health status allow for a rapid de-
intrathoracic pressure. monary vein without being exposed to termination of the severity of illness
Compared to adults, children, par- an aerated alveolar membrane, result- and often suggest which interventions
ticularly infants, are at higher risk of ing in hypoxemia. Examples of shunt may be required to appropriately in-
acute respiratory failure. The small di- are lung collapse and pulmonary ar- tervene to reverse the course of illness
ameter of children’s airway results in terial-venous connections. In most or to avoid respiratory arrest. Tachy-
a high resistance to flow. Resistance lung diseases, there is heterogeneity pnea and hypoxemia are common
is proportional to the inverse of the in V/Q mismatch from 0 to infinity manifestations of acute respiratory
radius of the airway to the 4th power; (Figure 1). failure, although tachycardia is often
thus, even small changes in the airway Respiratory failure may also be the an underappreciated sign of impend-
radius can result in large increases in result of impaired diffusion of oxygen ing respiratory failure. Increased work
airway resistance, leading to severely across the alveolar-capillary mem- of breathing manifests as retractions,
decreased airflow. The pediatric air- brane. Diffusion limitation may coex- grunting, head bobbing, nasal flaring,
way is small and can be further nar- ist with V/Q mismatch. An example or belly breathing. Children with re-
rowed by secretions, edema, or bron- of diffusion impairment is pulmonary spiratory failure due to neuromuscular
choconstriction. Young children also fibrosis. Hypercarbia due to diffu- weakness or central nervous system
have underdeveloped collateral venti- sion impairment is rare because CO2 dysfunction may not exhibit typical
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