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Application of Biotech PDF
Application of Biotech PDF
MEDICAL BIOTECHNOLOGY
WHAT IS MEDICAL OR RED
BIOTECHNOLOGY ?
Medical Biotechnology is the use of
living cells and cell materials to
research and produce pharmaceutical
and diagnostic products that help treat
and prevent human diseases.
BIOTECHNOLOGY -
CLASSIFICATION
Based on the field of
application biotechnology
can be classified in to
many…
RED BIOTECHNOLOGY WHITE BIOTECHNOLOGY
Or MEDICAL BIOTECHNOLOGY is
Or INDUSTRIAL BIOTECHNOLOGY is
biotechnology applied to manufacture
biotechnology applied to
pharmaceuticals like
industrial and other production
enzymes, antibiotics and vaccines, and
processes.
its use for molecular diagnostic.
BIOTECHNOLOGY
GREEN BLUE
BIOTECHNOLOGY BIOTECHNOLOGY
Or AGRICULTURAL BIOTECHNOLOGY
Or marine biotechnology is
is biotechnology applied to
marine and aquatic applications
agricultural processes and
of biotechnology
products.
APPLICATIONS OF MEDICAL BIOTECHNOLOGY
1. PHARMACOLOGY
2. GENE THERAPY
3. STEM CELLS
4. TISSUE ENGINEERING
APPLICATIONS OF MEDICAL BIOTECHNOLOGY
1. PHARMACOLOGY
2. GENE THERAPY
3. STEM CELLS
4. TISSUE ENGINEERING
PHARMACOLOGY
1. INSULIN
PRODUCTION
Production of genetically engineered human insulin was one of the first
breakthroughs of biotechnology in the pharmaceutical industry.
PROCESS:- The human gene for insulin is placed into bacteria, are cultured and
allowed to produce insulin which is collected, purified and sold to diabetics
worldwide.
Grow bacteria that make the insulin protein
(fermentation)
Isolate the protein from all the other stuff that was in the
fermentation tank (purification)
Convert the insulin to its active form (processing)
2.HUMAN GROWTH HORMONE
This gene that was inserted into the plasmid was created by reverse
transcription of the mRNA found in pituitary glands to complementary DNA.
Prior to this development, human growth hormone was extracted from the
pituitary glands of cadavers, as animal growth hormones have no
therapeutic value in humans.
3.HUMAN BLOOD CLOTTING FACTOR
1. PHARMACOLOGY
2. GENE THERAPY
3. STEM CELLS
4. TISSUE ENGINEERING
GENE THERAPY
It derives its name from the idea that DNA can be used to supplement or alter genes
within an individual's cells as a therapy to treat disease
The most common form of gene therapy involves using DNA that encodes a functional,
therapeutic gene to replace a mutated gene.
Gene therapy is of two types , somatic gene therapy and germ line gene therapy.
GENE THERAPY FOR DISEASES
The therapeutic gene called ADA was introduced into the bone
marrow cells of such patients in the laboratory, followed by
transplantation of the genetically corrected cells back to the same
patients.
Parkinson's Disease
Huntington's Disease
Influenza
HIV
Hepatitis
APPLICATIONS OF MEDICAL BIOTECHNOLOGY
1. PHARMACOLOGY
2. GENE THERAPY
3. STEM CELLS
4. TISSUE ENGINEERING
STEM CELLS
A stem cell is a cell that has the potential to
become any cell type in the human body.
Everyone has stem cells, but they are very hard to
access.
The easiest place to get stem cells is from an
embryo.
Stem cells are introduced into a damaged area of
the body where, under the right conditions, will
replace the damaged area.
Principles Application Process
Stem cells are The main areas where stem Often times stem
introduced into a cells have proven their cells are grown in
damaged area of the worth is in bone marrow a lab first to
body where, under the transplants, replacing ensure the right
right conditions, will damaged heart tissue after a conditions and
replace the damaged heart attack and replacing then placed into a
area. damaged nerve tissue which sick person.
gives hope to anyone who
has had a spinal cord injury.
Stem cells are currently being tested to treat everything from
Crohn’s disease to baldness!
The main areas where stem cells have proven their worth is in
bone marrow transplants, replacing damaged heart tissue after a
heart attack and replacing damaged nerve tissue which gives hope
to anyone who has had a spinal cord injury.
STEM CELLS (SOURCES)
Embryonic stem cells
Infant and adult stem cells
Present in small numbers in
Bone marrow
Peripheral blood
Skin epithelium
Umbilical cord blood
Dental pulp of infant’s teeth
May be obtained by reprogramming somatic cells
Introduction of retroviruses carrying reprogramming genes into
fibroblasts
APPLICATIONS OF MEDICAL BIOTECHNOLOGY
1. BIOPROCESSING
2. PHARMACOLOGY
3. GENE THERAPY
4. STEM CELLS
5. TISSUE ENGINEERING
TISSUE ENGINEERING