M ID L A N D S S I M L C M V E R s m

F A C U L T Y OK S C IE N C E AN D T E C H N O LO G Y

D E P A R T M E N ! O F B IO L O G IC A L S C IE N C E S

USc H O N O U R S IN B IO L O G IC A L S C IK S t K S S I \1 ES1 F R 1
A N D 2 E X A M IN A T IO N S

I I B I O 401: B IO M V T H E M A T IC S 11

l »l R A T IO N : 2 H O l R5 1100 M A R K S ) D A T E : IV N E 2M5

I 1

Answer J] IJ. R :■: cu ■ ■-<n \ u n j -[ j j c r ■../. I. -■ ION : - i.TiO N

TW O uuunions f-.>m S K TIQN H QuLiur-n ’ ■-Lrri^-5 ' 1v .jj: ■ l-j .!:
QUrs1:o:i iii Section B =rri^^ - J ~ i Lrk^ 'a - l'l1j. s:i.'n -j :r : -*
sufcdmsit nv [be irr- valueofea.t- -t.: ■
. i-io-n i- n t;. - KniiAevs 1 Iu -Itjt.-
>our v.hiT^ pcssib'tf Ivye ilc ir ij cc .liu.r^r.L’
 i

SfX I ION A
L. T h e d ata pt a g e m d p e a k h e art ra te f o r a ra n d o m ^ i-npl= o f 10 p t o p k are
g iv e n in ta b le I bcl-iw . I sc 1'W d a ta r la h l r I to ct q p c S u o fts ( a ) t o ( t ) .

T a b le ] . D a ta or. n\r.c and peal; h e art ra le

A ye fy ta r i) F'ea's heart rai r . -cjlh per siinuic)

3ft Kf.
38 S3
41 17]
38 17?
29 191
39 177
46 175
41 176
42 171
24 3%

i a) Draw 3 5*:ii^Lu: ploi £01 the data. (4I

( b ) H asfid o n y o u r scatteTjilot in ;a i. t o m m r r t o n * b a :cr it a p p it -pTiaie ;o use
;lic: lin e a r cui-relation c o e ffic ie n t 2* ii de& „r r i v e tti c a s _ re ftT t h e d a u . [3 J
( c ) C a lc u la te P e a r s o n 's c i i m b t i u : : e o c f t i: ; c t . : r 1 :'.i: t it datfl indc. mm:;:; OC, -he
r e ia t io r s h ip b e tw e e n The tw o v a ria b le s . [1 3 ]

SECTION B
W r it e ir. essay on th e p rin c ip le s o f e x p e rim e n ta l d -sign-

3, E y e in f la m m a tio n can h t in d jc e d by the endotC A ii lipopoty^cdahde (LPS).

A ra n d o m sa m p le o f 35 n t s w a s ra rH k c rjh d rvid c t into five gmijjj of sfcw
ra ts e a c h R a :s w ith in e-i^h l'Tm „ p re c e iv e d the sn::fc dose of 3PS. The data
o b ta in e d ljtl ^.asctila: p e rm e a b ility a> a r"L\-L'ure . t ihe iafianution are hjvijvm

in cable 2 b e lo w .

T a b le 2 U a la , n vaiC 4ilar p e r m c a b iliu o f r a i i t r e a ? c w ith I . f>

I'reatmtTil C n ^ : -p. 1 % j I.1- i-neahll:^-

0 * 3 2 I 0 0 O
I 4.5 4 4 3.5 3 2 6
10 5 5 4 3-5 1 0 0
100 13 12 12 9 8 4 2
500 13 12 9 7.5 7 5 4

l » G i v e the null and a lte rn a tiv e hyp ocheses f c i : h t stu d y m

 (b) State (i) the response variable, an! [21
(ii) factors) and its- their k*eU, 14]
u ) Discuss how ihiv nl.l hjvv1 I'ccn im p ^ c I [121
(d) 1l‘iinL; :hc SPSS .lUtpy: ; I ihlcs 3 :m;l -ii. patcrm all the rtcccsitn
proceiiurcs -ilid wrile youi cor.c rjsiuns dearly.

Tabic 3. SP S S Anova outpui

Sum of df Mean
Squares SaLia'e
Be^veen 291.'043 4 72.761 S 370 oo:
Groups
With n 27C.500 30 9 017
Groups
Total 561 543 34

Table £ ._ S P 5 S Multiple C anpanso^s output

Mean S ts iii; 95%
□ ^ fe 'e n cs :l- trrcfr Confide-;;
______ e '■te-val
(I i T R T (J)TR T Lcwe* U p p ef
Bour<J Bound
LSD 2 -1.00 16 .536 -4.25 228
3 -.64 1.6 692 -3 92 264
4 -6.57* 1.6 000 -9 55 -3.29
5 -6 21 * 16 .001 -5.49 -2 94
1 1.00 1.6 535 -2 23 4 28
3 36 1e 325 -2 92 3.54
4 -6 s r 15 C02 -8.65 -2 29
5 -5 2 1 * 15 .003 ■6.49 -1.94
1 64 1.6 .532 -26< 3 92
2 -.36 1.61 825 -3 64 2 92
4 '5 93’ 161 .001 -9.21 -2 65
5 -5.5 7' 1.51 002 -6.05 -2 2 9
1 6.57* 1.51 .■000 3.29 9.85
2 5 57* 1 61 .002 2.29 8.85
3 553* 1 61 001 2 65 921
5 .36 1 61 325 -: i : 3.54
1 6 . 21* 1.£1 001 2.94 949
2 5.21* iii 003 1.94 649
3 5.57* 1(1 .002 229 B 85
4 -.36 1 €1 .B25 -3.64 292
* Th e rr’ esn rii^ererice is sizmf.cant at :^e .05 Ieve

--------------
'r RX r v
la) Outline:
(0 the applications of linear regression. and m
(ii) the linear i t g r a i w anatysu procedure. |15]
(h) Write an interpretation o f the fo llo w i^ t t p K lt o l tine.ir fcvfcs> ^r
(i) tfie value of |3i arid P)
(ii) the cotjflfkienl of Je'erm — j;irn. m

(c) Briefly linn , fu n f i i f i nar itmnlfl take when using lin ear rcLTes-n.on
an alysis. 151

Discuss the assumptions of Analysis of Varuaceaod r,oH y ■_ ^ ,--jiJ deal

w itll data th^t Jo r.ot confirm: t" ‘ 'em.

F \ I) OK Q U E S 1 10V PA H Ek
TABLE "V f crlL'icfll valij*i

I M fvt
ten :™ ];
' ,1-jVi tt ' b jI jrc j

r L-nuciaJ vb Pue I ■-i;IM ■’.. oe

O.M-.-u c^ptu-^d .03 .90 .9$ /je -! 9 .999

'LofifxJunce let-t?* acrs: 90% 95% ge% 19“ 99 S1. S ?

1 ?, 0« 6.31 12.71 31 82 b .66 3iB.31 636j62

2 1.39 2.92 4.30 6.97 m am 316^
3 i .t* 2.35 3,13 434 1011 T292
4 133 2.13 2.78 J.7 J 60 7-t7 r 6i
5 1M 2.02 2 J7 3.37 .03 5J» 6.86
6 1.44 1.94 2,45 }.U " 5.21
7 I 41 1.90 137 300 t.50 4.79 5X1
8 I 441 1.S6 2.31 290 j.36 4.50
9 1.38 1.83 226 182 t.25 4 J0 47*
10 1.37 l.S l 2-23 276 S. 17 4-5*
LI 1.36 l.ftO 220 272 5.11 *0 3
12 1.3* 3,7ft 2.18 IM S S.Q6 3.93 -

422
:I
13 1-35 1 77 2.16 2.65 5.01 315
14 1 35 1.76 215 2.62 298 , 3.79 4 :4
15 1.34 1.75 213 2.60 295 3.7? ■1.07
16 1.34 1.75 112 2 ifl 292 3.69 i.u-:
■n 1.33 1.74 2.1 L 2^~ IS K 3.65
Oegrcts nLr
1.33 1 1.73 2 EO 235 2M ? 92
Ktrtd'.i'iti 15
19 ! -33 1.73 :.w 15* 2$* 3 55 3 J8
10 1.33 1.73 2.09 153 1.85 3 J5 3 *5
1.32 1.72 2 OS 251 283 153 3 52
21
22 1.22 1.72 207 131 1.12 731 379
-—
23 1.3? 1.11 107 2-50 2j81
3.75
2A 1.32 1.71 106 2.49 2K 3
25 1.32 i .71 106 249 1 79 3.45 3l73
1.71 2.00 2.4S IT S 3.4* 3.TJ
16 1.32
17 1.31 1.70 20? 2 i' 2.77 3L42 3 J®
2X . 1-31 1.70 205 247 176 3.41 3.67
1.31 1.70 205 246 276 3« 166
29
1-3J 1.70 104 246 275 3,39 365
30
40 1.30 1 68 2.02 242 270 3.31 3 55
1.30 1.67 200 2.59 266 3L23 3.46
60
1.29 Lb6 l.'JS 136 2.52 3.16 3.37
m

I 2H 1 645 1.96 2.33 2ife 3 09 329

■
: c ntlcal vpjuts
Lirvel of significance
.20 .10 .05 .02 .01 JJ01 .001
!cc a ; it'i'-LiLlcd CfSr
I e.'rc'. i ■
: nyiuiicajice
Tot a o>w utled jjic .10 05 .025 .01 JXi5 001
 ■a.,

X' 'l^ n ‘“ rfloni :Ji5‘ rcr- us:

N ,nr*>u.' at

01: r 2 3 4 5 8 TO ■l i

2 6.21 7.6? 4 46 9 92 O.'.’Ti 14.M 173

3 4,1$ JV tf sa» 5*4 > *2 3
■i 3.50 3.95 4 31 440 Jf 5 5 AC 6.25
5 3.16 \53 3 ii 4.03 4 .^ 4.77 S.25
. 6 2.<r.- '£ 9 3S i 3.71 ■ 3 Jft i? ; 370
7 ZM 3 S3 334 3-30 3.64 4 J& 4
* ; 2.75 3.P2 3.2* 3 J6 W \ 3JC 4 12
9 1 2JBB 2<K; 3.1’ 125 13* 3 *f 3 9? 'tl- j
10 2.63 ;^T7 .3.04 3.17 3JTS 3.33
11 2-59 2,52 2^9f 3.11 j-22 JL 9 3.73
;u 156 2.7? JW 3 3.0(5 m ; 3 J3 36?
13 2.55 2.75 2*1 3.01 J ■; Ai7 355
]■* 151 2 "J 2 L.Q 23$ 3 ^ 331 J 3^
15 2.49 2-W 7M 2.95 3.0* ? J9 3.+S
16 7 4.' L$7 2-iI 222 uu ■ 325
' TlT ;.+& 26t 2.7* 2.90 L22 ? 4:
2.4j In * "' T7 2.S* 2.96 32i» 3 J®
19 IIS 2 53 17i it * 20: ?.i7 3-35
; ao 2A ^ 2.51 2,?* 2.i5 3.13 5 .^
71
•J- >
i :- i 160 : ’5 1S3 l? t .14 3-31
22 2 41 2.V) 2.-; 2142 : ■ _~] 2 3 2?
2J 2.40 i ys 171 2t: 2 .^ IQ 3 27
21 2,39 '2.57 i- 0 _ .: ■ 3 i 09 ; .0-
2-5 -.53 ; 2j 57 2*9 •' 2.79 ■ LOS ?24
26 2.38 268 2.78 i . 'i :.«7 3n
**£
—>T
■ 2.27 .■i 5 J . 2.7 7 2..=t-' .■* , 3 22
.75 i
28' :r / 2 55 l/ .' z .-'t : ■■3 3 21
29 2.36 254 i.6ti 176 2.-.’ - 3JO - I
y:> 2.36 . 154 2 66 J 75 2--2 .0? 3.19
4-; 2.31 :.« ? JK 2.70 2 ’B .97 3-12
6a i 2j C 24* M* 2,66 2.73 .*! :o 6
130 127 24 ? 23i 2* 2 2 ? .86 !»
>r 1.39 250 258 2 .4 SI 19*

_ 5 ?i

* r\

^ r E u w v g ttrn r