ABSTRAK

ANALISIS ASAM RETINOAT PADA KRIM ANTI-ACNE YANG DIJUAL

DI KOTA BANJARBARU MENGGUNAKAN SPEKTROFOTOMETER
UV-VIS (Oleh Marina Kamila; Pembimbing: Nafila, S.Si, M.Si., Vebruati,
S.S, M.Pd; 2019; 65 halaman)
ABSTRACT
RETINOAT ACID ANALYSIS ON ANTI-ACNE CREAMS THAT WERE
SOLD IN BANJARBARU BY USING UV-VIS SPECTROFOTOMETER
(By Marina Kamila; Supervisor: Nafila, S.Si, M.Sc., Vebruati, S.S, M.Pd;
2019; 65 pages)

Asam retinoat merupakan salah satu zat aktif yang digunakan pada produk
anti-acne. Asam retinoat harus dibeli dengan menggunakan resep dokter dan
dibatasi kadar penggunaannya karena dalam jumlah yang berlebihan akan
menimbulkan efek samping seperti kulit kering, rasa terbakar, dan teratogenik
(cacat pada janin).
Retinoic acid is one of the active substances that is used in anti-acne
products. Retinoic acid must be purchased by using a prescription and is limited
for the level of its use because its excessive amounts will cause side effects such
as dry skin, burning, and teratogenic (fetal defects).
Analis ini dilakukan bertujuan untuk mengetahui ada tidaknya dan berapa
kadar asam retinoat yang terkandung di dalam produk krim anti-acne yang dijual
di kota Banjarbaru. Analisis untuk kualitatif dan kuantitatif asam retinoat
dilakukan dengan spektrofotometer UV-Vis.
This analysis was conducted to find out whether or not retinoic acid and
how much its level was on anti-acne cream products that were sold in Banjarbaru.
Retinoic acid analysis was for qualitative and quantitative of retinoic acid was
carried out by UV-Vis spectrophotometer.
Hasil penelitian menunjukkan bahwa dari sepuluh sampel terdapat satu
sampel yang mengandung asam retinoat dengan kadar 0,06% yang memenuhi
persyaratan kadar tetapi dijual bebas di kota Banjarbaru. Hasil validasi metode
analisis asam retinoat didapatkan hasil akurasi 89,1157%, presisi
1,5670%, LOD 0,1215 mg/l dan LOQ 0,4050 mg/l. Hasil validasi
menunjukkan bahwa metode spektrofotometer UV-Vis pada analisis asam retinoat
memiliki tingkat akurasi, presisi, linearitas, LOD dan LOQ yang masuk dalam
persyaratan baik.
The results showed that from ten samples there was one sample that was
containing of 0.06% retinoic acid which fulfilled the level requirements but it was
sold freely in Banjarbaru. The results of the validation of the method of retinoic
acid analysis showed an accuracy of 89.1157%, precision of 1.5670%, LOD of
0.1215 mg / l and LOQ of 0.4050 mg / l. Validation results showed that the UV-
Vis spectrophotometer method in the retinoic acid analysis had a level of
accuracy, precision, linearity, LOD and LOQ that was in good terms.
Kata kunci: asam retinoat, krim anti-acne, spektrofotometer UV-Vis.
Keywords: retinoic acid, anti-acne cream, UV-Vis spectrophotometer.
 ABSTRACT

RETINOAT ACID ANALYSIS IN ANTI-ACNE CREAM THAT IS SOLD

IN BANJAR CITY USING UV-VIS SPECTROFOTOMETER (By Marina
Kamila; Advisor: Nafila, S.Si, M.Si., Vebruati, S.S, M.Pd; 2019; 65 pages)

Retinoic acid is one of the active substances used in anti-acne products.

Retinoic acid should be purchased using a doctor's prescription and is restricted in
its use because excessive amounts will cause side effects such as dry skin, burning
taste, and teratogenic (disability of the fetus). This analyst aims to determine
whether and what levels of retinoic acid are contained in the anti-acne cream
products sold in the city of Banjarbaru. Analyses for qualitative and quantitative
retinoic acid were carried out with UV-Vis spectrophotometers. The results
showed that out of 10 samples contained 1 sample of retinoic acid with a rate of
0.06% that fulfilled the requirements of levels but Sold freely in the city of
Banjarbaru. Results of validation of the analysis method of retinoic acid obtained
by 89.1157% accuracy, 1.5670% precision, LOD 0.1215 mg/L and LOD 0.4050
mg/L. Validation results indicate that the UV-Vis spectrophotometer method on
retinoic acid analyses has the level of accuracy, precision, linearity, LOD and
LOQ that are included in good terms.

Keywords: retinoic acid, anti-acne cream, UV-Vis spectrophotometer.