ative Bi Cre & USA:1-6315 & Europe: 44- © Emaik:info © Address: 45-1 Ramsey Road, Shirley, NY 1967, USA. 7 ° & Tek 1-631-559-9269 1-516-512-3133 Creative BioMart © Eno ivoderentve-bomortcom Transporters ‘Transport proteins are proteins that transport substances across biological membranes. Transport proteins are found within the membrane itself, where they form a channel, or a carrying mechanism, to allow their substrate to pass from one side to the other, Very few molecules enter or leave cells, or cross organellar membranes, unaided by proteins. Even transport of molecules, such as water and urea that can diffuse across pure phospholipid bilayers, is frequently accelerated by transport proteins. All the transport proteins exhibit a high degree of specificity for the substance transported, ‘Transporters are typically expressed in all organs involved in the uptake, distribution, and elimination of drugs, including the gastrointestinal tract, the blood-brain barrier, the liver, and the kidneys. Interaction of drugs with transporters can alter their behavior in membrane transport, which may result in, for example, active uptake, efflux, and rapid elimination. In other words, the pharmacokinetics of a drug may be influenced by transporters. Apart from a metabolic component, drug-drug and drug-nutrient interactions may involve transporters. There is hope that in the near future the experimental 3D structures of the key transporters will be elucidated, However, while the basic knowledge of transporters is rapidly growing, their real clinical significance remains open to debate despite some convincing theories. To study the functional properties of the different kinds of transport proteins, researchers need experimental systems in which a particular transport protein predominates. Creative BioMart provides a set of high purity recombinant transporter proteins, which are convenient research tools for transporter functional properties study, 2/4. 7 ° & Tek 1-631-559-9269 1-516-512-3133 Creative BioMart © Eno ivoderentve-bomortcom FU A aa Tad Source Wheat germ Species Human Tag GST or N/A Applications E2¥™e-inked lmmunoabsorbent Assay: Western Blot (Recombinant protein); Antibody Production; Protein Array storage ‘50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. Store at -80, centigrade, Aliquot to avoid repeated freezing and thawing Prune rt Breed) ey [poeta ABCB7-23H Recombinant Human ABCB7, GST-tagged 99-783 104.99 SLC29A2-654H Recombinant Human SLC29A2 Protein, GST-tagged +361 65.45 ABCD3-O5SH Recombinant Human ABCDS Protein, GST-Tagged 1-296 517 SLC28A1-655H Recombinant Human SLC28A1 Protein, GST-tagged 1259 $423 TIMMI8-656H Recombinant Human TIMMIS Protein, GST-tagged 1-95 3619 ABCG4-068H Recombinant Human ABCG4 Protein, GST-Tagged 1-646 968 SLC39A7-657H Recombinant Human SLC39A7 Protein, GST-tagged 1-469 7m SLC39AS-659H Recombinant Human SLC39AS Protein, GST-tagged 25398283 TAP2-660H Recombinant Human TAP2 Protein, GST-tagged 1-686 1012 ABCC13-046H Recombinant Human ABCC13 Protein, GST-Tagged 14169 459 ABCC5-049H —_ Recombinant Human ABCCS Protein, GST-Tagged 1-208 501 SLC7A9-662H Recombinant Human SLC7A9 Protein, GST-tagged 1-487 799 TAAR6-663H Recombinant Human TAAR6 Protein, GST-tagged, 1.845 649 ABCAG-034H Recombinant Human ABCAG Protein, GST-Tagged 14185 478 ABCC6-O51H Recombinant Human ABCC6 Protein, GST-Tagged 199 372 SLC23A2-664H Recombinant Human SLC28A2 Protein, GST-tagged 1-425, 28 SLC35AF665H Recombinant Human SLC35A1 Protein, GST-tagged 1.887 632 SLCGATL-666H Recombinant Human SLC6AN Protein, GST-tagged 1-208 49.4 ABCC10-043H Recombinant Human ABCC10 Protein, GST-Tagged 1-282 ST CUTC-2188H Recombinant Human CUTC Protein, GST-tagged 1273 587 ABCA8-O36H Recombinant Human ABCA8 Protein, GST-Tagged 1-266 S12 TAP2-660H Recombinant Human TAP2 Protein, GST-tagged 1-686 1012 ABCF2-060H Recombinant Human ABCF2 Protein, GST-Tagged 1-628 977 SLOTIAM264H Recombinant Human SLCTIAl protein, @ST-tagged 1-178 456Creative BioMart” SLO35D2-667H ABCD1-3738H CLONS1418H SLCO22AS-668H ABCG219H ABCET-OS7H SLC29A1-669H SLO22A2-670H ABCGLOG3H SLO39A8-671H SLC13A3-672H SLO39A10-673H ABCCTI-O44H SLO43A2-674H DIRC2-S196H SLCSA1-2775H ‘TAPL-67SH SLO26A4-317H TAARG-676H SLC22A1-677H SLC39A12-678H ABCG8-069H STK39-679H ABCG2-06SH SLCI0A1-680H SLO39A14-681H SLCO22A16-682H Recombinant Human SLC35D2 Protein, GST-tagged, Recombinant Human ABCD!, GST-tagged Recombinant Human CLONS Protein, GST-tagged Recombinant Human SLO22A5 Protein, GST-tagged Recombinant Human ABCG2, GST-tagged Recombinant Human ABCE1 Protein, GST-Tagged Recombinant Human SLC29A1 Protein, @ST-tagged Recombinant Human SLC22A2 Protein, GST-tagged Recombinant Human ABCGI Protein, GST- Tagged Recombinant Human SLO39A8 Protein, GST-tagged, Recombinant Human SLC18A Protein, GST-tagged Recombinant Human SLO39A10 Protein, GST-tagged Recombinant Human ABCC1I Protein, GST-Tagged Recombinant Human SLC49A2 Protein, @ST-tagged, Recombinant Human DIRC2 Protein, GST-tagged Recombinant Human SLCSA\, GST-tagged Recombinant Human TAPI Protein, GST-tagged Recombinant Human SLC26A4 protein, GST-tagged, Recombinant Human TAARG Protein Recombinant Human SLC22A1 Protein Recombinant Human SLO39A\12 Protein Recombinant Human ABCG8 Protein Recombinant Human STK39 Protein, GST-tagged Recombinant Human ABCG2 Protein Recombinant Human SLC10A1 Protein Recombinant Human SLC39A14 Protein Recombinant Human SLC22A16 Protein %& USA: 1-631-559-9269 %& Europe: 44-207-0974828 %& Tek 1-631-559-9269 & Email:info@creative-biomartcom 1-249 1745 1746 1-887 1-655 1-899 1-456 1-885 1-678 1-460 1-602 1-831 1-853 1-869 1-478 1-664 1-808 1-780 1-916-512-3193, & Email:info@creative-biomart.com 1516-512-9193 531 1093 1095 891 987 937 766 89 102 76 93.2 1205 88 891 788 99.99 1136 1278 385 or 761 7a 859 23 38.4 53 638 Fox: -631-988-8127 © Address: 45-1 Ramsey Road, Shirley, NY 1967, USA