LAMPIRAN

1) Senyawa Etoposida

- Rerank Score Before Align

- Ikatan Hidrogen
- Interaksi Sterik

2) Senyawa 2A

- MM2 Minimization

Pi System: 22 15 1 2 3 4 6 5 19 8 10 9 11 13 12 16 17 21 18 23 24

Warning: Some parameters are guessed (Quality = 1).

Iteration 412: Minimization terminated normally because the gradient norm is less than the
minimum gradient norm

Stretch: 2.3368

Bend: 17.1253

Stretch-Bend: 0.1348
Torsion: 10.8536

Non-1,4 VDW: 3.0956

1,4 VDW: 22.6741

Dipole/Dipole: 3.5873

Total Energy: 59.8075 kcal/mol

Calculation completed

- MMFF94 Minimization

Iteration 269: Minimization terminated normally because the gradient norm is less than the
minimum gradient norm

Final Energy: 110.741 kcal/mol

Calculation completed

- Non Align
- Align
3) Senyawa 2B

- Rerank Score Align

- Rerank Score Not Align

- Ikatan Hidrogen Align

- Ikatan Hidrogen Non Align

- Interaksi Sterik Align

- Interaksi Sterik Non Align
4) Senyawa 2C

- Rerank Score Align

- Rerank Score Non Align

- Hidrogen Bonds & Interaksi Sterik Before Align

- Hidrogen Bonds After Align

- Interaksi Sterik After Align

5) Senyawa 2D

- Sebelum Align

- Ikatan Hidrogen dan Interaksi Sterik Before Align

- Rerank Score After Align

- Ikatan Hidrogen After Align

- Interaksi Sterik After Align

6) Senyawa 2E

- Rerank Score Before Align

- Rerank Score After Align

- Ikatan Hidrogen Before Align

- Ikatan Hidrogen After Align

- Interaksi Sterik After Align

7) Senyawa 2F

- Rerank Score Before Align

- Rerank Score After Align

- Ikatan Hidrogen Before Align

- Ikatan Hidrogen After Align

- Ikatan Sterik Before and After Align

8) Senyawa 2G

- Rerank Score Before Align

- Rerank Score After Align

- Ikatan Hidrogen dan Sterik Before Align

- Ikatan Hidrogen dan Sterik After Align