ABSTRAK

Firani, Sinta. 2014. Pengaruh Pemberian Ekstrak Buah Labu Siam (Sechium
edule) Terhadap Perbaikan Profil Lipid Pada Tikus Putih Jantan (Rattus
norvegicus strain wistar) Dislipidemia. Tugas Akhir. Fakultas Kedokteran
Universitas Muhammadiyah Malang. Pembimbing : (1) Diah Hermayanti
* (2) Annisa Hanifwati **

Latar Belakang : Dislipidemia adalah kelainan metabolisme lemak yang ditandai

dengan peningkatan atau penurunan fraksi lipid dalam plasma. Labu siam
(Sechium edule) merupakan bahan alam yang memiliki kandungan serat larut
yaitu pektin. Pektin mempunyai efek mencegah penyerapan lemak dan kolesterol.
Tujuan : Mengetahui pengaruh ekstrak buah labu siam (Sechium edule) terhadap
perbaikan profil lipid pada tikus putih (Rattus norvegicus strain wistar)
dislipidemia.
Metode : True experimental dengan post test only control group design. Sampel
penelitian dibagi lima kelompok. Analisis data menggunakan One way ANOVA,
uji turkey 5%, uji korelasi, dan uji regresi.
Hasil : Pada kadar trigliserida, LDL, rasio LDL/HDL, rasio KT/HDL sig 0.000 <
p (0.05) terdapat perbedaan bermakna. Pada kadar kolesterol total sig 0,060 > p
(0.05) tidak terdapat perbedaan bermakna.
Kesimpulan : Ekstrak labu siam berpengaruh terhadap kadar trigliserida, LDL,
HDL, rasio LDL/HDL, rasio KT/HDL.

Kata Kunci : Ekstrak labu siam, Pektin, Rattus norvegicus strain wistar, perbaikan
profil lipid

*) : Ketua Program Studi FK UMM ; Staf Pengajar Ilmu Patologi Klinik FK

UMM
**) : Staf pengajar FK UMM

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 ABSTRACT

Firani, Sinta. 2014. The Effect of Chayote (Sechium edule) Extract on the
Repairment of Lipid Profile on Dyslipidemia Mice (Rattus norvegicus
strain wistar). Final Assignment. Faculty Of Medicine, Muhammadiyah
University Of Malang. Advisor: (1) Diah Hermayanti*; (2) Annisa
Hanifwati**

Background : Dyslipidemia is a disorder of lipid metabolism characterized by an

increase or decrease in plasma lipid fractions. Chayote (Sechium edule) is a
natural ingredient and has soluble dietary, well known as pectin. Pectin has
signifficant effect of preventing absorption of fat and cholesterol.
Purpose : To investigate the effect of chayote (Sechium edule) extract on the
repairment of lipid profile on dyslipidemia mice (Rattus norvegicus strain wistar).
Method: True experimental with post test only control group design. The samples
were divided in five groups. Data analysis using a One way ANOVA test, turkey
5% test, correlation test, and linier regression test.
Results : At the levels of triglycerides, LDL, HDL, ratio of LDL/HDL, and ratio
of KT/HDL sig 0000 < p (0.05), there is a significant difference. In total
cholesterol sig 0.060 > p (0.05), not significantly different.
Conclusion : Chayote extract effect on improvement of the levels of triglycerides,
LDL, HDL, ratio of LDL/HDL, and ratio of KT/HDL.

Key words: Chayote extracts, Pectin, Rattus norvegicus strain wistar, repairment
of lipid profile

*) : Chief of Program, Faculty of Medicine, UMM ; Staff Lecturer Division

of Clinical Pathology, Faculty of Medicine ,UMM
**) : Staff Faculty of Medicine, UMM

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