Kadar paracetamol dalam plasma darah sukarelawan setelah pemberian dosis tunggal

500mg paracetamol secara oral

no t (jam) Cp Cp C residual Cp C AUC
(µg/ml) terminal 1 distribusi residual
2
1. 0.00 0.000 4.066 -4.066 12.323 16.389 1.199125
2. 0.25 9.593 3.872 5.721 11.028 5.307 2.714375
3. 0.50 12.122 3.688 8.434 9.870 1.436 3.134125
4. 0.75 12.951 3.512 9.439 8.833 0.606 3.036625
5. 1.00 11.342 3.345 7.997 7.905 0.092 5.13925
6. 1.50 9.215 3.035 6.180 6.331 0.151 4.274
7. 2.00 7.881 2.753 5.128 5.071 0.058 6.635
8. 3.00 5.389 2.265 3.124 3.253 0.129 4.6305
9. 4.00 3.872 1.864 2.008 2.086 0.078 3.1555
10. 5.00 2.439 1.534 0.905 1.338 0.433 2.0655
11. 6.00 1.692 1.262. 0.430 0.859 0.428 2.54
12. 8.00 0.848 0.854 -0.006 0.353 0.360 1.428
13. 10.00 0.580 0.578 0.002 0.145 0.144 0.968
14. 12.00 0.388 0.392 -0.004 0.060 0.063 1.989744

Persamaan Paracetamol Tunggal

y=12.323e(-0.444.t)+4.0656e(-0.195.t)-16.888e(-4.87.t)

Perhitungan Paracetamol Tunggal

 Cp terminal
1. Cp terminal = 4,0656e-0,195 . 0
= 4,0656e-0
= 4,066
2. Cp terminal = 4,0656e-0,195 . 0,25
= 4,0656e-0,0488
= 3,872
3. Cp terminal = 4,0656e-0,195 . 0,50
= 4,0656e-0,0975
= 3,688
4. Cp terminal = 4,0656e-0,195 . 0,75
= 4,0656e-0,14625
= 3,512
5. Cp terminal = 4,0656e-0,195 . 1
= 4,0656e-0,195
= 3,345
6. Cp terminal = 4,0656e-0,195 . 1,5
= 4,0656e-0,2925
= 3,053
7. Cp terminal = 4,0656e-0,195 . 2
= 4,0656e-0,39
= 2,753
8. Cp terminal = 4,0656e-0,195 . 3
= 4,0656e-0,585
= 2,265
9. Cp terminal = 4,0656e-0,195 . 4
= 4,0656e-0,78
= 1,864
10. Cp terminal = 4,0656e-0,195 . 5
= 4,0656e-0,975
=1,534
11. Cp terminal = 4,0656e-0,195 . 6
= 4,0656e-1,17
= 1,262
12. Cp terminal = 4,0656e-0,195 . 8
= 4,0656e-1,56
= 0,854
 13. Cp terminal = 4,0656e-0,195 . 10
= 4,0656e-1,95
= 0,578
14. Cp terminal = 4,0656e-0,195 . 12
= 4,0656e-2,34
= 0,392
 C Residual I ( Cp – Cp terminal )
1. C residual = 0,000 – 4,066
= - 4,066
2. C residual = 9,593 – 3,872
= 5,721
3. C residual = 12,122 – 3,688
= 8,343
4. C residual = 12,951 – 3,512
= 9,439
5. C residual = 11,342 – 3,345
= 7.997
6. C residual = 9,215 – 3,035
= 6.180
7. C residual = 7,881 – 2,753
= 5.128
8. C residual = 5,389 – 2,265
= 3.124
9. C residual = 3,872 – 1,864
= 2.008
10. C residual = 2,439 – 1,534
 = 0.905
11. C residual = 1,692 – 1,262
= 0.430
12. C residual = 0,848 – 0,854
= -0.006
13. C residual = 0,580 – 0,578
= 0.002
14. C residual = 0,388 – 0,392
= -0.004
 Cp Distribusi
1. Cp Distribusi = 12,323e-0,444 . 0
= 12,323e-0
= 12,323
2. Cp Distribusi = 12,323e-0,444 . 0,25
= 12,323e-0,111
= 11,028
3. Cp Distribusi = 12,323e-0,444 . 0,50
= 12,323e-0,222
= 9,870
4. Cp Distribusi = 12,323e-0,444 . 0,75
= 12,323e-0,333
= 8,833
5. Cp Distribusi = 12,323e-0,444 . 1
= 12,323e-0,444
= 7,905
6. Cp Distribusi = 12,323e-0,444 . 1,5
= 12,323e-0,666
 = 6,331
7. Cp Distribusi = 12,323e-0,444 . 2
= 12,323e-0,888
= 5,071
8. Cp Distribusi = 12,323e-0,444 . 3
= 12,323e-1,332
= 3,253
9. Cp Distribusi = 12,323e-0,444 . 4
= 12,323e-1,776
= 2,086
10. Cp Distribusi = 12,323e-0,444 . 5
= 12,323e-2,220
= 1,338
11. Cp Distribusi = 12,323e-0,444 . 6
= 12,323e-2,664
= 0,859
12. Cp Distribusi = 12,323e-0,444 . 8
= 12,323e-3,552
= 0,353
13. Cp Distribusi = 12,323e-0,444 . 10
= 12,323e-4,440
= 0,145
14. Cp Distribusi = 12,323e-0,444 . 12
= 12,323e-5,328
= 0,060
Kadar paracetamol dalam plasma darah enam sukarelawan setelah pemberian
kombinasi paracetamol 500mg dan fenilpropanolamin hidroklorida 50mg secara oral.

no t (jam) Cp Cp C residual Cp C AUC

(µg/ml) terminal 1 distribusi residual
2
1. 0 0 2.128 -2.128 7.644 9.772 0.514375
2. 0.25 4.115 2.038 2.077 6.725 4.648 1.158875
3. 0.5 5.156 1.951 3.205 5.917 2.712 1.3495
4. 0.75 5.64 1.868 3.772 5.206 1.434 1.394875
5. 1 5.519 1.788 3.731 4.581 0.850 2.66775
6. 1.5 5.152 1.639 3.513 3.546 0.034 2.3605
7. 2 4.29 1.503 2.787 2.745 0.042 3.5955
8. 3 2.901 1.263 1.638 1.645 0.007 2.4725
9. 4 2.044 1.061 0.983 0.986 0.003 1.7
10. 5 1.356 0.892 0.464 0.591 0.127 1.134
11. 6 0.912 0.749 0.163 0.354 0.191 1.442
12. 8 0.53 0.529 0.001 0.127 0.126 0.9
13. 10 0.37 0.374 -0.004 0.046 0.049 0.634
14. 12 0.264 0.264 0.000 0.016 0.016 1.517241

Persamaan Paracetamol Kombinasi

y= 7.6435e(-0.512.t)+ 2.1283e(-0.174.t)- 9.4445e(-2.564.t)

Kadar fenilpropanolamin hidroklorida dalam plasma pada enam sukarelawan setelah

pemberian fenilpropanolamin hidroklorida 50 mg secara oral.
no t (jam) Cp Cp C residual Cp C AUC
(µg/ml) terminal 1 distribusi residual
2
1. 0 0 0.123 -0.123 0.813 0.9358 0.008625
2. 0.25 0.069 0.120 -0.051 0.689 0.74013 0.029125
3. 0.5 0.164 0.118 0.046 0.584 0.537427 0.0485
4. 0.75 0.224 0.115 0.109 0.495 0.385807 0.061375
5. 1 0.267 0.113 0.154 0.419 0.264823 0.14225
6. 1.5 0.302 0.108 0.194 0.301 0.106792 0.148
7. 2 0.29 0.103 0.187 0.216 0.029262 0.245
8. 3 0.2 0.094 0.106 0.112 0.005792 0.175
9. 4 0.15 0.086 0.064 0.058 0.006239 0.1285
10. 5 0.107 0.079 0.028 0.030 0.001562 0.092
11. 6 0.077 0.072 0.005 0.015 0.010476 0.137
12. 8 0.06 0.060 0.000 0.004 0.004473 0.111
13. 10 0.051 0.051 0.000 0.001 0.000635 0.093
14. 12 0.042 0.042 0.000 0.000 0.000597 0.47191

Persamaan fenilpropanolamin hidroklorida tunggal

y= 0.8127e(-0.662.t) + 0.1231e(-0.089.t) - 0.9492e(-1.109.t)

Kadar fenilpropanolamin hidroklorida dalam plasma pada enam sukarelawan setelah

pemberian kombinasi fenilpropanolamin hidroklorida 50 mg dan paracetamol 500 mg
secara oral.

no t (jam) Cp Cp C residual Cp C AUC

(µg/ml) terminal 1 distribusi residual
2
1. 0 0 0.073 -0.073 0.591 0.664 0.00175
2. 0.25 0.014 0.071 -0.057 0.491 0.548 0.0105
3. 0.5 0.07 0.070 0.000 0.408 0.408 0.021875
4. 0.75 0.105 0.069 0.036 0.339 0.303 0.029375
5. 1 0.13 0.068 0.062 0.281 0.219 0.07375
6. 1.5 0.165 0.066 0.099 0.194 0.095 0.0795
7. 2 0.153 0.063 0.090 0.134 0.044 0.1355
8. 3 0.118 0.059 0.059 0.064 0.005 0.1045
9. 4 0.091 0.055 0.036 0.030 0.005 0.078
10. 5 0.065 0.052 0.013 0.014 0.001 0.06
11. 6 0.055 0.048 0.007 0.007 0.000 0.097
12. 8 0.042 0.042 0.000 0.002 0.002 0.079
13. 10 0.037 0.037 0.000 0.000 0.000 0.069
14. 12 0.032 0.032 0.000 0.000 0.000 0.470588

Persamaan fenilpropanolamin kombinasi

y=0.5909e(-0.742.t) + 0.0726e(-0.068.t) - 0.6752e(-0.973.t)